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公开(公告)号：US5282823A
公开(公告)日：1994-02-01
申请号：US853682
申请日：1992-03-19
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5799384A
公开(公告)日：1998-09-01
申请号：US736001
申请日：1996-10-23
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
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公开(公告)号：US5651174A
公开(公告)日：1997-07-29
申请号：US429451
申请日：1995-04-27
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A method for making a radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film applied to the cylindrical body such that it extends between the metal elements of the stent. Therapeutic substances may be incorporated within the applied film. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于制造径向扩张的支架用于植入体腔内的方法，所述支架具有开放的近端和远端的具有大致圆柱形的主体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱体沿着身体的纵向轴线弯曲 由此支架可以符合弯曲体腔和施加到圆柱体的聚合物膜，使得其在支架的金属元件之间延伸。 治疗物质可以并入施加的膜中。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5443496A
公开(公告)日：1995-08-22
申请号：US138041
申请日：1993-10-15
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5370614A
公开(公告)日：1994-12-06
申请号：US155402
申请日：1993-11-19
CPC分类号： A61M25/104 , A61F2/958 , A61L29/16 , A61F2250/0067 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/622 , A61M2025/105 , A61M2025/1081 , A61M2025/1086 , A61M25/1002
摘要： A balloon catheter includes a sheath surrounding the balloon, the sheath having a longitudinal line of weakness and a drug-containing viscous matrix material intermediate between the balloon and the sheath such that when the balloon is positioned and inflated in the body lumen it causes the sheath to burst at the line of weakness and release viscous matrix material onto said body lumen. The device provides accurate placement of the dosage required at the location in need of treatment. The catheter is especially useful in balloon angioplasty procedures.
摘要翻译： 球囊导管包括围绕球囊的护套，护套具有纵向弱线线和中间在球囊和护套之间的药物粘性基质材料，使得当球囊定位并在体腔内充气时，其导致鞘 在弱点处爆裂，并将粘性基质材料释放到所述体腔上。 该装置提供了在需要治疗的位置所需的剂量的准确放置。 导管在球囊血管成形术中特别有用。
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公开(公告)号：US5304122A
公开(公告)日：1994-04-19
申请号：US981959
申请日：1992-11-24
CPC分类号： A61F2/88
摘要： A model of arterial restenosis in domestic pigs using deep injury to the coronary arterial media resulting in extensive proliferative response. Metal wire coils are delivered percutaneously to the coronary arteries of pigs with an oversized, high pressure (14 atm) balloon and left in place for 5-6 weeks. During placement, the balloon expands the coils and delivers them securely within the arterial lumen causing fracture of the internal elastic lamina by the coil. An extensive proliferative response occurs and is associated with a lumenal area narrowing of at least 50% Immunohistochemical studies confirms the prominence of smooth muscle cells in the tissue. The histopathologic features of the proliferative response are identical to those observed in cases of restenosis post-angioplasty.This model closely mimics the proliferative portion of human restenosis both grossly and microscopically. It may thus be useful for understanding human restenosis and for testing therapies aimed at preventing restenosis after balloon angioplasty or other coronary interventional procedures.
摘要翻译： 家猪的动脉再狭窄模型，对冠状动脉介质使用深度损伤，导致广泛的增殖反应。 将金属丝线经皮经皮递送至具有超大，高压（14atm）气球的猪的冠状动脉，并留在原位5-6周。 在放置期间，气囊扩张线圈并将其牢固地传送到动脉管腔内，从而引起内部弹性层被线圈断裂。 发生广泛的增殖反应并且与至少50％的狭窄区域相关联。免疫组织化学研究证实了组织中平滑肌细胞的突出。 增殖反应的组织病理学特征与在血管成形术后再狭窄情况下观察到的组织病理学特征相同。 该模型严重和微观上模仿人类再狭窄的增殖部分。 因此，可能有助于了解人类再狭窄和用于测试旨在防止气囊血管成形术或其他冠状动脉介入手术后再狭窄的疗法。
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公开(公告)号：US5324261A
公开(公告)日：1994-06-28
申请号：US989412
申请日：1992-12-11
CPC分类号： A61M25/104 , A61F2/958 , A61L29/16 , A61F2250/0067 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/622 , A61M2025/105 , A61M2025/1081 , A61M2025/1086 , A61M25/1002
摘要： A balloon catheter includes a sheath surrounding the balloon, the sheath having a longitudinal line of weakness and a drug-containing viscous matrix material intermediate between the balloon and the sheath such that when the balloon is positioned and inflated in the body lumen it causes the sheath to burst at the line of weakness and release viscous matrix material onto said body lumen. The device provides accurate placement of the dosage required at the location in need of treatment. The catheter is especially useful in balloon angioplasty procedures.
摘要翻译： 球囊导管包括围绕球囊的护套，护套具有纵向弱线线和中间在球囊和护套之间的药物粘性基质材料，使得当球囊定位并在体腔内充气时，其导致鞘 在弱点处爆裂，并将粘性基质材料释放到所述体腔上。 该装置提供了在需要治疗的位置所需的剂量的准确放置。 导管在球囊血管成形术中特别有用。
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公开(公告)号：US5893840A
公开(公告)日：1999-04-13
申请号：US637112
申请日：1996-04-24
CPC分类号： A61M25/104 , A61F2/958 , A61F2250/0067 , A61M2025/105 , A61M2025/1081 , A61M2025/1086
摘要： Balloon catheters are prepared to include body affecting chemicals within microcapsules on the exterior of the balloon either alone or with a stent. The coating releases from the balloon when the balloon is inflated into contact with the lumen to be treated. The device provides accurate placement of the dosage required at the location in need of treatment. A sheath may be employed over the balloon and microcapsules to prevent the microcapsules from being rubbed off during delivery through a body lumen. The catheters are especially useful in balloon angioplasty procedures.
摘要翻译： 球囊导管准备包括单独或与支架在气囊外部的微胶囊内影响化学物质的物质。 当气球膨胀与待处理的内腔接触时，涂层从球囊释放。 该装置提供了在需要治疗的位置所需的剂量的准确放置。 可以在气囊和微胶囊上使用护套以防止在通过体腔输送期间微胶囊被摩擦。 导管在球囊血管成形术程序中特别有用。
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公开(公告)号：US5484449A
公开(公告)日：1996-01-16
申请号：US167279
申请日：1993-12-13
CPC分类号： A61F2/88 , A61F2/958 , A61M2025/0183
摘要： A stent and catheter device for temporary support of body lumens. The stent has a generally cylindrical continuous winding providing radial support from within a body lumen after implantation which can be implanted and removed by a balloon catheter. The stent is provided with an elongated lead attached to the proximal end of the winding and means at a proximal end of the lead and remote from the winding for uncoiling the winding to facilitate its removal in an opened condition with minimal tissue damage. This stent and catheter device is especially useful as a temporary supporting device for repairing damage to blood vessels caused during angioplasty procedures.
摘要翻译： 用于临时支撑体腔的支架和导管装置。 支架具有大体上圆柱形的连续绕组，其在植入后从体腔内提供径向支撑，其可以通过球囊导管植入和移除。 支架设置有细长的引线，其附接到绕组的近端，并且在引线的近端处的装置和远离绕组的装置，用于展开绕组，以便于在打开状态下以最小的组织损伤去除它。 该支架和导管装置特别可用作用于修复在血管成形术过程中引起的血管损伤的临时支撑装置。
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公开(公告)号：USD325437S
公开(公告)日：1992-04-14
申请号：US312785
申请日：1989-02-21
申请人： Vincent W. Hull
设计人： Vincent W. Hull
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