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公开(公告)号：US5282823A
公开(公告)日：1994-02-01
申请号：US853682
申请日：1992-03-19
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5799384A
公开(公告)日：1998-09-01
申请号：US736001
申请日：1996-10-23
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
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公开(公告)号：US5651174A
公开(公告)日：1997-07-29
申请号：US429451
申请日：1995-04-27
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A method for making a radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film applied to the cylindrical body such that it extends between the metal elements of the stent. Therapeutic substances may be incorporated within the applied film. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于制造径向扩张的支架用于植入体腔内的方法，所述支架具有开放的近端和远端的具有大致圆柱形的主体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱体沿着身体的纵向轴线弯曲 由此支架可以符合弯曲体腔和施加到圆柱体的聚合物膜，使得其在支架的金属元件之间延伸。 治疗物质可以并入施加的膜中。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US5443496A
公开(公告)日：1995-08-22
申请号：US138041
申请日：1993-10-15
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译： 一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可 符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。 支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。 支架对于修复血管成形术过程中引起的血管损伤特别有用。
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公开(公告)号：US06923986B2
公开(公告)日：2005-08-02
申请号：US10650163
申请日：2003-08-27
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： C08G65/32 , A61K9/00 , A61K9/107 , A61K9/127 , A61K9/14 , A61K9/20 , A61K9/51 , A61K9/70 , A61K38/17 , A61K47/32 , A61K47/34 , A61K48/00 , A61L15/58 , A61L15/60 , A61L24/00 , A61L24/04 , C08F299/02 , C08G18/40 , C08G63/00 , C08G63/672 , C08G65/329 , C08L71/02 , A61K31/765 , C08L53/00
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US06410645B1
公开(公告)日：2002-06-25
申请号：US09710416
申请日：2000-11-09
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
IPC分类号： A61K31765
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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8.发明授权
公开(公告)号：US4650614A
公开(公告)日：1987-03-17
申请号：US402254
申请日：1982-07-27
IPC分类号： C07C309/04 , C07C143/02
CPC分类号： C07C303/44
摘要： Reaction grade 2-acrylamido-2-methylpropane sulfonic acid is refined by mildly heating a slurry-like suspension formed of the acid and a liquid monohydric alcohol, recovering the acid from the alcohol and subsequently drying it.
摘要翻译： 通过温和加热由酸和液体一元醇形成的淤浆状悬浮液来精制反应级2-丙烯酰氨基-2-甲基丙磺酸，从醇中回收酸，随后将其干燥。
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9.发明申请公开(公告)号：US20180258207A1
公开(公告)日：2018-09-13
申请号：US15760830
申请日：2016-09-19
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08F228/02 , C08F236/04 , C08F299/02 , C08K5/41 , A61L27/16 , A61L29/04 , A61L31/04
CPC分类号： C08F228/02 , A61L27/16 , A61L27/54 , A61L29/041 , A61L29/16 , A61L31/048 , A61L31/16 , C08F236/04 , C08F299/022 , C08F2810/30 , C08G75/00 , C08G75/0286 , C08G75/23 , C08G81/00 , C08G85/004 , C08K5/41 , C08L81/00
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
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公开(公告)号：US20110305872A1
公开(公告)日：2011-12-15
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译： 一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有 在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟 。
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