公开(公告)号：US20070242260A1

公开(公告)日：2007-10-18

申请号：US11698277

申请日：2007-01-26

申请人： Robert Thorne ,  Guanhan Chew

发明人： Robert Thorne ,  Guanhan Chew

IPC分类号： G01N1/00

CPC分类号： G01N1/286 ,  B01L3/505 ,  B01L3/5088 ,  B01L2200/147 ,  B01L2300/028

摘要： Microfabricated tools useful for manipulating small, delicate samples are formed from thin plastic films. The films have a small thickness (preferably 5 to 50 micrometers and typically 10 micrometers) and small lateral dimensions (preferably 2 mm or less and typically 0.1 to 1 mm) so that they are reasonably flexible, but are preferably curved by being wrapped around a cylindrical or flat post to give them some rigidity. The softness and thinness of the plastic reduce risk of sample damage during incidental contact with the tool. Its thinness makes it optically and X-ray transparent, so that the samples can be clearly visualized during manipulations and so that the tools can be used to collect X-ray data from samples. As an option, an X-ray sensitive phosphor is incorporated in the film at low concentration. This allows the X-ray beam to be visually located on the mount or tool. The plastic can also be treated to obtain a desired hydrophobicity or hydrophilicity, mechanically embossed or abraded, or coated with films (for example, of polyethylene glycol via pegylation procedures or of PDMS) that promote or inhibit sample adhesion.

摘要翻译： 用于操作小而精细样品的微型工具由薄塑料膜形成。 膜的厚度（优选为5至50微米，典型为10微米）和较小的横向尺寸（优选2mm或更小，通常为0.1至1毫米），使得它们具有相当的柔性，但优选通过围绕 圆柱形或扁平柱，给它们一些刚性。 塑料的柔软性和薄度降低了与工具偶然接触时样品损坏的风险。 其薄度使其光学和X射线透明，使样品在操作过程中可以清晰可视，从而可以使用这些工具从样品采集X射线数据。 作为选择，在低浓度下将X射线敏感性荧光体掺入膜中。 这允许X射线束在视觉上位于安装件或工具上。 也可以处理塑料以获得所需的疏水性或亲水性，机械压花或磨损，或涂覆促进或抑制样品粘附的膜（例如聚乙二醇通过聚乙二醇化程序或PDMS）。

公开(公告)号：US20100132483A1

公开(公告)日：2010-06-03

申请号：US12609379

申请日：2009-10-30

申请人： Robert E. Thorne ,  Guanhan Chew

发明人： Robert E. Thorne ,  Guanhan Chew

IPC分类号： G01N1/00

CPC分类号： G01N1/286 ,  B01L3/505 ,  B01L3/5088 ,  B01L2200/147 ,  B01L2300/028

摘要： Microfabricated tools useful for manipulating small, delicate samples are formed from thin plastic films. The films have a small thickness (preferably 5 to 50 micrometers and typically 10 micrometers) and small lateral dimensions (preferably 2 mm or less and typically 0.1 to 1 mm) so that they are reasonably flexible, but are preferably curved by being wrapped around a cylindrical or flat post to give them some rigidity. The softness and thinness of the plastic reduce risk of sample damage during incidental contact with the tool. Its thinness makes it optically and X-ray transparent, so that the samples can be clearly visualized during manipulations and so that the tools can be used to collect X-ray data from samples. As an option, an X-ray sensitive phosphor is incorporated in the film at low concentration. This allows the X-ray beam to be visually located on the mount or tool. The plastic can also be treated to obtain a desired hydrophobicity or hydrophilicity, mechanically embossed or abraded, or coated with films (for example, of polyethylene glycol via pegylation procedures or of PDMS) that promote or inhibit sample adhesion.

摘要翻译： 用于操作小而精细样品的微型工具由薄塑料膜形成。 膜的厚度（优选为5至50微米，典型为10微米）和较小的横向尺寸（优选2mm或更小，通常为0.1至1毫米），使得它们具有相当的柔性，但优选通过围绕 圆柱形或扁平柱，给它们一些刚性。 塑料的柔软性和薄度降低了与工具偶然接触时样品损坏的风险。 其薄度使其光学和X射线透明，使样品在操作过程中可以清晰可视，从而可以使用这些工具从样品采集X射线数据。 作为选择，在低浓度下将X射线敏感性荧光体掺入膜中。 这允许X射线束在视觉上位于安装件或工具上。 也可以处理塑料以获得所需的疏水性或亲水性，机械压花或磨损，或涂覆促进或抑制样品粘附的膜（例如聚乙二醇通过聚乙二醇化程序或PDMS）。

公开(公告)号：US08210057B2

公开(公告)日：2012-07-03

申请号：US12609379

申请日：2009-10-30

申请人： Robert E. Thorne ,  Guanhan Chew

发明人： Robert E. Thorne ,  Guanhan Chew

IPC分类号： G01N1/00

CPC分类号： G01N1/286 ,  B01L3/505 ,  B01L3/5088 ,  B01L2200/147 ,  B01L2300/028

摘要： Microfabricated tools useful for manipulating small, delicate samples are formed from thin plastic films. The films have a small thickness (preferably 5 to 50 micrometers and typically 10 micrometers) and small lateral dimensions (preferably 2 mm or less and typically 0.1 to 1 mm) so that they are reasonably flexible, but are preferably curved by being wrapped around a cylindrical or flat post to give them some rigidity. The softness and thinness of the plastic reduce risk of sample damage during incidental contact with the tool. Its thinness makes it optically and X-ray transparent, so that the samples can be clearly visualized during manipulations and so that the tools can be used to collect X-ray data from samples. As an option, an X-ray sensitive phosphor is incorporated in the film at low concentration. This allows the X-ray beam to be visually located on the mount or tool. The plastic can also be treated to obtain a desired hydrophobicity or hydrophilicity, mechanically embossed or abraded, or coated with films (for example, of polyethylene glycol via pegylation procedures or of PDMS) that promote or inhibit sample adhesion.

摘要翻译： 用于操作小而精细样品的微型工具由薄塑料膜形成。 膜的厚度（优选为5至50微米，典型为10微米）和较小的横向尺寸（优选2mm或更小，通常为0.1至1毫米），使得它们具有相当的柔性，但优选通过围绕 圆柱形或扁平柱，给它们一些刚性。 塑料的柔软性和薄度降低了与工具偶然接触时样品损坏的风险。 其薄度使其光学和X射线透明，使样品在操作过程中可以清晰可视，从而可以使用这些工具从样品采集X射线数据。 作为选择，在低浓度下将X射线敏感性荧光体掺入膜中。 这允许X射线束在视觉上位于安装件或工具上。 也可以处理塑料以获得所需的疏水性或亲水性，机械压花或磨损，或涂覆促进或抑制样品粘附的膜（例如聚乙二醇通过聚乙二醇化程序或PDMS）。