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公开(公告)号：US20240253049A1
公开(公告)日：2024-08-01
申请号：US18539222
申请日：2023-12-13
Applicant: Essenlix Corporation
Inventor： Stephen Y. CHOU , Wei DING , Ji QI , Yufan ZHANG
IPC: B01L3/00 , G01N21/03 , G01N21/84 , G01N33/543
CPC classification number: B01L3/50853 , B01L3/5088 , G01N21/03 , G01N21/84 , G01N33/543 , G01N33/54366 , B01L2300/04 , B01L2300/0609 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861
Abstract: The present invention, among other things, provides the devices and methods in manipulate a sample for the purpose of assaying.
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公开(公告)号：US20240042428A1
公开(公告)日：2024-02-08
申请号：US18265494
申请日：2021-12-07
Applicant: Essenlix Corporation
Inventor： Stephen Y. CHOU , Wei DING
CPC classification number: B01L3/5027 , B01L3/5088 , B01L3/527 , G01N1/2813 , G01N21/251 , G01N21/6486 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/086
Abstract: A device for liquid sample collection and liquid sample analysis, including: a base plate having: at least one pedestal area in at least a portion of a sample image area; and at least one recessed area, wherein at least of a portion of the at least one pedestal area is adjacent to the at least one recessed area; a cover plate that opposes the base plate; a plurality of spacers attached to one of the base plate, the cover plate, or both, and the spacers are situated between the opposable plates; and an exterior liquid sample contact area on an exterior location of the device; wherein the base plate and the cover plate define an interior cavity in fluid communication with the exterior liquid sample contact area. Also disclosed are an apparatus including the device, a method of making the device, and a method of using the device.
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公开(公告)号：US11883824B2
公开(公告)日：2024-01-30
申请号：US16081970
申请日：2018-02-09
Applicant: Essenlix Corporation
Inventor： Stephen Y. Chou , Wei Ding , Ji Qi , Yufan Zhang
IPC: B01L3/00 , G01N21/84 , G01N33/543 , G01N21/03
CPC classification number: B01L3/50853 , B01L3/5088 , G01N21/03 , G01N21/84 , G01N33/543 , G01N33/54366 , B01L2300/04 , B01L2300/0609 , B01L2300/0829 , B01L2300/0851 , B01L2300/0861
Abstract: Disclosure relates to a device and a method of using the device for conducting biological and chemical assays on a sample. The device includes two plates. The first plate includes at least a first and a second sample contact areas on its inner surface. Each sample contact area includes spacers having a bottom end fixed on the inner surface and a top end that is distal to the inner surface. The spacers in the first sample contact area differ in height from those in the second sample contact area. The first and second sample contact areas are disposed at different depths along the inner surface of the first plate, so that the top ends of the spacers are aligned on the same flat plane. The method includes depositing the sample onto the sample contact areas, compressing the sample into a thin layer, and analyzing the sample.
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公开(公告)号：US20230256449A1
公开(公告)日：2023-08-17
申请号：US17996982
申请日：2021-04-28
Applicant: POLITECNICO DI MILANO , FONDAZIONE CENTRO SAN RAFFAELE
Inventor： Elena BIANCHI , Oronza Antonietta BOTRUGNO , Gabriele Angelo DUBINI , Monica PIERGIOVANNI , Giovanni TONON , Paola DE STEFANO , Luca LEONI , Pietro OLDANI
IPC: B01L3/00
CPC classification number: B01L3/5088 , B01L3/5085 , B01L2300/161 , B01L2300/0829
Abstract: A micro-droplet plate including at least one fixed element which is a rigid flat support which has an upper face and a lower face, having, on said upper face, wells connected together by microchannels, said wells being delimited by a hydrophobic rim and crossed by a hole, where said wells and said microchannels define at least one microfluidic circuit; and moving elements, received in said wells through said holes, which are cylinders having an upper base and a lower base. The moving elements move, even independently of each other, along their vertical axis, and the upper base of said moving elements includes a hydrophilic surface with relief items.
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公开(公告)号：US20180353960A1
公开(公告)日：2018-12-13
申请号：US16044166
申请日：2018-07-24
Applicant: Orca Biosystems, Inc.
Inventor： Ivan K. Dimov , Nathaniel Fernhoff , Lagnajeet Pradhan
CPC classification number: B01L3/502715 , B01L3/50853 , B01L3/5088 , B01L9/523 , B01L2200/0605 , B01L2300/0829 , G01N15/1436 , G01N21/6402 , G01N21/6458 , G01N2015/149 , G02B21/16 , H01S5/18388 , H01S5/423
Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
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Patent Agency Ranking
公开(公告)号：US20180318827A1
公开(公告)日：2018-11-08
申请号：US16037153
申请日：2018-07-17
Applicant: Wisconsin Alumni Research Foundation
Inventor： David J. Beebe , Ben P. Casavant , David J. Guckenberger , Scott M. Berry
CPC classification number: B01L3/0268 , B01L3/50825 , B01L3/5088 , B01L3/563 , B01L2200/025 , B01L2200/0657 , B01L2200/0668 , B01L2300/042 , B01L2400/021 , B01L2400/043
Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
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公开(公告)号：US20180266955A1
公开(公告)日：2018-09-20
申请号：US15984443
申请日：2018-05-21
Applicant: FUJIFILM Corporation
Inventor： Kota KATO
IPC: G01N21/64 , G01N21/552 , G01N21/01
CPC classification number: G01N21/648 , B01L3/0262 , B01L3/5088 , B01L2300/0654 , B01L2300/0819 , B01L2300/168 , G01N1/2813 , G01N21/01 , G01N21/554 , G01N35/1065 , G01N2001/2826
Abstract: A solution attachment device includes: an ejection tool having an ejection opening that ejects a solution in a direction of gravitational force; and a solution attachment control portion for controlling attachment of the solution ejected from the ejection opening to at least one attachment subject region of the solution formed on a substrate in a state in which the at least one attachment subject region is disposed below an end surface including the ejection opening of the ejection tool in the direction of gravitational force, and, in the state, a first projection region obtained by projecting the end surface to a surface perpendicular to the direction of gravitational force substantially overlaps a second projection region obtained by projecting the at least one attachment subject region to the surface.
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8.发明申请公开(公告)号：US20180250672A1
公开(公告)日：2018-09-06
申请号：US15779459
申请日：2016-11-30
Applicant: Illumina, Inc.
Inventor： Arash Jamshidi , Yan-you Lin , Farnaz Absalan , Sarah Stuart , Gordon Cann , Yir-Shyuan Wu , Tarun Khurana , Jeffrey S Fisher
IPC: B01L3/00 , C12Q1/6806
CPC classification number: B01L3/502761 , B01L3/502784 , B01L3/5088 , B01L2200/0605 , B01L2200/0642 , B01L2200/0668 , B01L2300/0819 , B01L2300/165 , B01L2400/0427 , B01L2400/043 , C12Q1/6806 , C12Q1/6869 , C12Q2563/143 , C12Q2563/149 , C12Q2563/185 , G01N1/28 , G01N33/54333 , G01N2015/1006 , C12Q2535/122
Abstract: In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.
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9.发明申请公开(公告)号：US20180250670A1
公开(公告)日：2018-09-06
申请号：US15759218
申请日：2016-09-05
Applicant: ELVESYS
Inventor： MAËL LE BERRE , ADRIEN PLECIS
CPC classification number: B01L3/5088 , B01L2200/0684 , B01L2300/0822 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , G01N21/01 , G02B21/34
Abstract: A micro-structured substrate to support a liquid sample having a lower face and an upper face. At least one surface cavity of volume V0 opening onto the upper face and forming a zone for analyzing the liquid sample. A first groove having a first volume V1, positioned around each surface cavity and opening onto the upper face thereof. The substrate also includes at least one second groove opening onto the upper face thereof and positioned around the first groove. The sum of the volumes of the second grooves is equal to V2. The volume V1+V2 is greater than or equal to 0.05 V0, preferably 0.1 V0. An analysis assembly including the substrate and the use thereof is also contemplated herein.
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公开(公告)号：US09891157B2
公开(公告)日：2018-02-13
申请号：US13991378
申请日：2011-12-05
Applicant: Massimo Bocchi , Roberto Guerrieri
Inventor： Massimo Bocchi , Roberto Guerrieri
CPC classification number: G01N15/1404 , B01L3/50273 , B01L3/502792 , B01L3/5088 , B01L2200/0652 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0424 , B03C5/005 , B03C5/022 , B03C5/026 , B03C2201/26 , C12M23/12 , C12M29/10 , C12M41/46 , G01N1/4077 , G01N15/1484 , G01N27/44791 , G01N33/50 , G01N33/5005 , G01N2015/1415 , G01N2015/1481 , G01N2015/149
Abstract: An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.
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