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1.发明授权Apparatus and method for selecting a preferred pacing vector in a cardiac resynchronization device 有权用于在心脏再同步装置中选择优选起搏载体的装置和方法公开(公告)号：US09199087B2
公开(公告)日：2015-12-01
申请号：US13301043
申请日：2011-11-21
IPC分类号： A61N1/368
CPC分类号： A61N1/3684 , A61N1/3686
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy including selecting left ventricular pacing sites for delivering the therapy. The left ventricular pacing sites are selected by delivering pacing pulses to a patient's left ventricle at multiple pacing sites one at a time and determining right ventricular activation times in response to the pacing pulses being delivered at each of the pacing sites. A left ventricular pacing site is selected in response to the determined right ventricular activation times.
摘要翻译： 医疗设备和相关方法控制心脏起搏疗法的递送，包括选择用于递送治疗的左心室起搏部位。 通过在多个起搏部位一次一个地向患者的左心室递送起搏脉冲来选择左心室起搏部位，并且响应于在每个起搏部位递送的起搏脉冲来确定右心室激活时间。 响应于确定的右心室激活时间来选择左心室起搏部位。
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2.发明授权Method and apparatus for adaptive cardiac resynchronization therapy employing a multipolar left ventricular lead 有权使用多极左心室导联的自适应心脏再同步治疗的方法和装置公开(公告)号：US08639333B2
公开(公告)日：2014-01-28
申请号：US13301012
申请日：2011-11-21
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译： 医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗 心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。 在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。 响应于激活时间确定选择第一起搏站点。 该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。
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3.发明申请APPARATUS AND METHOD FOR SELECTING A PREFERRED PACING VECTOR IN A CARDIAC RESYNCHRONIZATION DEVICE 有权在心脏再生装置中选择优选的载体矢量的装置和方法公开(公告)号：US20130131751A1
公开(公告)日：2013-05-23
申请号：US13301043
申请日：2011-11-21
IPC分类号： A61N1/365
CPC分类号： A61N1/3684 , A61N1/3686
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy including selecting left ventricular pacing sites for delivering the therapy. The left ventricular pacing sites are selected by delivering pacing pulses to a patient's left ventricle at multiple pacing sites one at a time and determining right ventricular activation times in response to the pacing pulses being delivered at each of the pacing sites. A left ventricular pacing site is selected in response to the determined right ventricular activation times.
摘要翻译： 医疗设备和相关方法控制心脏起搏疗法的递送，包括选择用于递送治疗的左心室起搏部位。 通过在多个起搏部位一次一个地向患者的左心室递送起搏脉冲来选择左心室起搏部位，并且响应于在每个起搏部位递送的起搏脉冲来确定右心室激活时间。 响应于确定的右心室激活时间来选择左心室起搏部位。
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4.发明授权Left-ventricular pacing site selection guided by electrogram morphology analysis 有权通过电描记图形态分析指导左心室起搏部位选择公开(公告)号：US09180300B2
公开(公告)日：2015-11-10
申请号：US13598784
申请日：2012-08-30
IPC分类号： A61N1/00 , A61N1/362 , A61B5/00 , A61B5/0452 , A61N1/368
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译： 医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。 建立第一形态学模板并存储在设备的存储器中。 处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。 处理器将确定的心脏信号形态与第一形态学模板进行比较。 响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。
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5.发明申请公开(公告)号：US20130131750A1
公开(公告)日：2013-05-23
申请号：US13301012
申请日：2011-11-21
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译： 医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗 心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。 在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。 响应于激活时间确定选择第一起搏站点。 该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。
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6.发明申请LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 审中-公开电子形态分析指导的左心室选择选择公开(公告)号：US20130053918A1
公开(公告)日：2013-02-28
申请号：US13598815
申请日：2012-08-30
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device system and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A control unit is operatively coupled with a plurality of electrodes for controlling the delivery of the pacing pulses, and a sensing module senses a cardiac signal generated in response to the delivered pacing pulses. A processor is configured to deliver a first pacing pulse at a first timing interval to a first pacing site, determine the cardiac signal sensed in response to the delivered first pacing pulse and determine a first morphology corresponding to the determined sensed cardiac signal, compare the first morphology to a threshold morphology and adjust the first timing interval to a second timing interval different from the first timing interval in response to the comparing, and determine the optimal pacing site in response to the adjusting.
摘要翻译： 医疗器械系统和相关方法对候选起搏电极部位进行分类，以将起搏脉冲输送到患者的心脏。 控制单元与多个电极可操作地耦合，用于控制起搏脉冲的传送，并且感测模块感测响应于所输送的起搏脉冲而产生的心脏信号。 处理器被配置为以第一定时间隔将第一起搏脉冲传送到第一起搏位置，确定响应于所传送的第一起搏脉冲而感测的心脏信号，并且确定对应于所确定的感测到的心脏信号的第一形态，比较第一起搏脉冲 形态到阈值形态，并且响应于比较将第一定时间隔调整到与第一定时间隔不同的第二定时间隔，并且响应于调整确定最佳起搏位置。
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7.发明申请LEFT-VENTRICULAR PACING SITE SELECTION GUIDED BY ELECTROGRAM MORPHOLOGY ANALYSIS 有权电子形态分析指导的左心室选择选择公开(公告)号：US20130053916A1
公开(公告)日：2013-02-28
申请号：US13598784
申请日：2012-08-30
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61B5/04525 , A61B5/7264 , A61N1/362 , A61N1/3684 , A61N1/3686
摘要： A medical device and associated method classify candidate pacing electrode sites for delivering pacing pulses to a patient's heart. A first morphology template is established and stored in memory of the device. A processor is configured to determine a cardiac signal morphology in response to delivering pacing pulses at a candidate pacing site in a first heart chamber. The processor compares the determined cardiac signal morphology to the first morphology template. The pacing site in the first heart chamber is classified in response to the comparing of the determined cardiac signal morphology and the first morphology template.
摘要翻译： 医疗装置和相关联的方法对候选起搏电极位置进行分类，以将起搏脉冲输送到患者的心脏。 建立第一形态学模板并存储在设备的存储器中。 处理器被配置为响应于在第一心室中的候选起搏部位处输送起搏脉冲来确定心脏信号形态。 处理器将确定的心脏信号形态与第一形态学模板进行比较。 响应于确定的心脏信号形态与第一形态学模板的比较，将第一心室中的起搏部位分类。
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公开(公告)号：US09480844B2
公开(公告)日：2016-11-01
申请号：US12915093
申请日：2010-10-29
CPC分类号： A61N1/3702 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing a cardiac signal, detecting a cardiac event in response to the sensed signal, determining whether an interval associated with the cardiac signal is less than an interval threshold, determining a noise metric in response to an interval associated with the cardiac signal being less than the interval threshold, determining whether the noise metric is greater than a noise metric threshold, and determining whether to inhibit detecting in response to determining whether an interval associated with the cardiac signal is less than the interval threshold and determining whether the noise metric is greater than the noise metric threshold.
摘要翻译： 一种用于检测医疗设备中的心脏事件的方法和装置，包括感测心脏信号，响应于感测信号检测心脏事件，确定与心脏信号相关联的间隔是否小于间隔阈值，确定噪声 响应于与所述心脏信号相关联的间隔小于所述间隔阈值的度量，确定所述噪声度量是否大于噪声度量阈值，以及响应于确定与所述心脏信号相关联的间隔是否是禁止检测 小于间隔阈值并确定噪声度量是否大于噪声度量阈值。
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9.发明授权Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权用于检测皮下医疗装置中的心律失常的方法和装置公开(公告)号：US09174062B2
公开(公告)日：2015-11-03
申请号：US11687094
申请日：2007-03-16
申请人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
发明人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
IPC分类号： A61B5/00 , A61N1/362 , A61N1/39 , A61B5/0464 , A61B5/0468 , A61B5/046 , A61N1/05
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, determining a relationship between a plurality of characteristics associated with a morphology of the cardiac signals sensed during a predetermined sensing window, generating a threshold in response to the determined relationship, comparing a first characteristic of the plurality of characteristics with the threshold, and determining whether the sensed cardiac signals are associated with the cardiac event in response to the comparing of the first characteristic.
摘要翻译： 一种用于检测医疗设备中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，确定与在预定感测窗口期间感测到的心脏信号的形态有关的多个特征之间的关系，产生阈值 响应于所确定的关系，将所述多个特征的第一特征与所述阈值进行比较，并且响应于所述第一特征的比较，确定所感测的心脏信号是否与心脏事件相关联。
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公开(公告)号：US08983585B2
公开(公告)日：2015-03-17
申请号：US12768944
申请日：2010-04-28
申请人： Xusheng Zhang , Robert W. Stadler
发明人： Xusheng Zhang , Robert W. Stadler
IPC分类号： A61B5/04 , A61N1/362 , A61B5/0464 , A61N1/39 , A61B5/00
CPC分类号： A61N1/3622 , A61B5/0464 , A61B5/686 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for monitoring a patient's heart rhythm sensing a cardiac signal determine whether a cardiac signal is noise corrupted by obtaining cardiac signal pulses and generating a pulse amplitude threshold in response to the plurality of signal pulses. The number of signal sample points exceeding the pulse amplitude threshold in each of the of signal pulses is computed. The cardiac signal is determined to be noise corrupted or non-corrupted in response to the computed number of signal sample points.
摘要翻译： 用于监测感测心脏信号的患者心律的医疗装置和相关方法通过获得心脏信号脉冲并响应于多个信号脉冲产生脉冲幅度阈值来确定心脏信号是否被噪声破坏。 计算每个信号脉冲中超过脉冲振幅阈值的信号采样点数。 响应于所计算的信号采样点数，心脏信号被确定为噪声损坏或未被破坏。
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