公开(公告)号：US20110282437A1

公开(公告)日：2011-11-17

申请号：US13105488

申请日：2011-05-11

申请人： Robert W. Warner ,  Steve Kangas ,  Liliana Atanasoska ,  Joseph Thomas Ippoliti ,  Scott R. Schewe

发明人： Robert W. Warner ,  Steve Kangas ,  Liliana Atanasoska ,  Joseph Thomas Ippoliti ,  Scott R. Schewe

IPC分类号： A61F2/82

CPC分类号： A61F2/915 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0067

摘要： In embodiments, a stent comprises a biodegradable polymer functionalized with an adhesion-enhancing amino acid.

摘要翻译： 在实施方案中，支架包括用粘附增强的氨基酸官能化的可生物降解的聚合物。

公开(公告)号：US06211374B1

公开(公告)日：2001-04-03

申请号：US09064974

申请日：1998-04-22

申请人： Joseph Thomas Ippoliti

发明人： Joseph Thomas Ippoliti

IPC分类号： C07D21560

CPC分类号： C07D409/04 ,  C07D491/10

摘要： The present invention provides water-soluble, pyran-based photochromic compounds characterized by improved stability when in an open, excited configuration. The advantages of the present invention are provided, at least in part, by functionalizing a pyran-based photochromic compound with carboxylate functionality in such a way that the carboxylate and/or its counter ion have sufficient mobility to engage in intermolecular and intramolecular interactions. In preferred embodiments, such a mobile carboxylate and/or counter ion provided on one side of an open pyran ring is preferably capable of complexing with functionality on the other side of the open pyran ring, greatly stabilizing the open configuration.

摘要翻译： 本发明提供了水溶性的基于吡喃的光致变色化合物，其特征在于当处于开放的，激发的构型时提高了稳定性。 本发明的优点至少部分地通过以羧酸官能团的官能化方式使羧酸盐和/或其抗衡离子具有足够的迁移率以进行分子间和分子内的相互作用来进行官能化。 在优选的实施方案中，提供在开放吡喃环的一侧上的这种可移动羧酸酯和/或抗衡离子优选能够与开放吡喃环的另一侧上的官能团络合，极大地稳定了开放构型。

公开(公告)号：US20080233601A1

公开(公告)日：2008-09-25

申请号：US12053992

申请日：2008-03-24

申请人： Joseph Thomas Ippoliti ,  Joshua Cole Speros

发明人： Joseph Thomas Ippoliti ,  Joshua Cole Speros

IPC分类号： G01N33/53 ,  C07D403/02

CPC分类号： G01N33/533 ,  C07D403/04

摘要： Disclosed are compounds having the formula: wherein R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, amino, N-C1-C6-alkylamino, and N,N—C1-C6-dialkylamino; and ring “A” is selected from the group consisting of unsubstituted or substituted C4-C8-cycloalkenyl, unsubstituted or substituted bicyclo [2,2,1]alkenyl, and unsubstituted or substituted bicyclo [2,2,2]alkenyl, unsubstituted phenyl, and phenyl substituted with a moiety selected from the group consisting of C3-C6-alkenyl, acryl, acryl-C1-C6 alkyl, acrylamido, and acrylamido-C1-C6 alkyl; polymers made from these compounds, and ELISAs that use the compounds and polymers as a chemiluminescent detection label.

摘要翻译： 公开了具有下式的化合物：其中R 1选自氢，C 1 -C 6烷基，氨基，NC C 1 -C 6 - 烷基氨基和N，NC 1 -C 6 - 二烷基氨基; 环“A”选自未取代或取代的C 4 -C 8 - 环烯基，未取代或取代的双环[2,2,1]烯基， 和未取代或取代的双环[2,2,2]链烯基，未被取代的苯基，和被选自C 3 -C 6 -C 6 - 烯基 ，丙烯酰基，丙烯酰基-C 1 -C 6烷基，丙烯酰胺基和丙烯酰氨基-C 1 -C 6 - 烷基; 由这些化合物制成的聚合物，以及使用化合物和聚合物作为化学发光检测标签的ELISA。

公开(公告)号：US08148173B2

公开(公告)日：2012-04-03

申请号：US12053992

申请日：2008-03-24

申请人： Joseph Thomas Ippoliti ,  Joshua Cole Speros

发明人： Joseph Thomas Ippoliti ,  Joshua Cole Speros

IPC分类号： G01N33/533 ,  C07D237/30

CPC分类号： G01N33/533 ,  C07D403/04

摘要： Disclosed are compounds having the formula: wherein R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, amino, N—C1-C6-alkylamino, and N,N—C1-C6-dialkylamino; and ring “A” is selected from the group consisting of unsubstituted or substituted C4-C8-cycloalkenyl, unsubstituted or substituted bicyclo[2,2,1]alkenyl, and unsubstituted or substituted bicyclo[2,2,2]alkenyl, unsubstituted phenyl, and phenyl substituted with a moiety selected from the group consisting of C3-C6-alkenyl, acryl, acryl-C1-C6 alkyl, acrylamido, and acrylamido-C1-C6 alkyl; polymers made from these compounds, and ELISAs that use the compounds and polymers as a chemiluminescent detection label.

摘要翻译： 公开了具有下式的化合物：其中R1选自氢，C1-C6烷基，氨基，N-C1-C6-烷基氨基和N，N-C1-C6-二烷基氨基; 环“A”选自未取代或取代的C4-C8-环烯基，未取代或取代的双环[2,2,1]烯基，和未取代或取代的双环[2,2,2]烯基，未取代的苯基 和被选自C 3 -C 6 - 烯基，丙烯酰基，丙烯基-C 1 -C 6烷基，丙烯酰胺基和丙烯酰氨基-C 1 -C 6烷基的部分取代的苯基; 由这些化合物制成的聚合物，以及使用化合物和聚合物作为化学发光检测标签的ELISA。

公开(公告)号：US20080286812A1

公开(公告)日：2008-11-20

申请号：US12054283

申请日：2008-03-24

申请人： Joseph Thomas Ippoliti ,  Katherine E. Olson

发明人： Joseph Thomas Ippoliti ,  Katherine E. Olson

IPC分类号： G01N33/53

CPC分类号： G01N33/581 ,  G01N33/543

摘要： Disclosed is an assay for detecting an analyte. The method includes the steps of contacting a solution suspected of containing the analyte with capture antibodies specific for the analyte, wherein analyte contained in the solution is captured by the capture antibodies. Then contacting the capture antibodies with a solution containing the analyte attached to an alcohol oxidase (AOX) enzyme, to yield captured, labeled analyte. Then contacting the capture antibodies with a reagent mixture that generates a first signal proportional to the captured, labeled analyte and quantifying the first signal. And then measuring concentration of the analyte in the unknown sample by comparing the first signal to standard curve of signals. The assay can be implemented in an ELISA format.

摘要翻译： 公开了用于检测分析物的测定法。 该方法包括以下步骤：将疑似含有分析物的溶液与分析物特异的捕获抗体接触，其中包含在溶液中的分析物被捕获抗体捕获。 然后将捕获抗体与含有连接到醇氧化酶（AOX）酶的分析物的溶液接触，以产生捕获的标记分析物。 然后将捕获抗体与试剂混合物接触，所述试剂混合物产生与所捕获的标记分析物成比例的第一信号并量化第一信号。 然后通过比较第一个信号与信号的标准曲线来测量未知样品中分析物的浓度。 该测定可以以ELISA形式实施。