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    Medical copolymers
    5.
    发明授权
    Medical copolymers 有权
    医用共聚物

    公开(公告)号：US08187623B2

    公开(公告)日：2012-05-29

    申请号：US12491467

    申请日：2009-06-25

    申请人： J. Thomas Ippoliti ,  Scott Schewe ,  Robert W. Warner ,  Michele Zoromski

    发明人： J. Thomas Ippoliti ,  Scott Schewe ,  Robert W. Warner ,  Michele Zoromski

    IPC分类号： A61F2/00 ,  A61K9/14

    CPC分类号： C08G61/08 ,  A61L31/06 ,  A61L31/10 ,  C08G61/12 ,  C08G2261/147 ,  C08G2261/3324 ,  C08G2261/3342 ,  C08G2261/418

    摘要： Medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of —R9— groups within the polymer backbone, wherein R9 comprises a radical-substituted C2-C10 cyclic or heterocyclic group, or (iii) both a plurality of —C═C— groups and a plurality of —R9— groups within the polymer backbone, (b) a plurality of hydrocarbon-based pendant groups along the polymer backbone that comprise a saturated or unsaturated carbon chain of at least four carbons in length, and (c) a plurality of zwitterionic pendant groups along the polymer backbone that comprise a positively charged quaternary ammonium group and a negatively charged phosphate group. Methods of forming such copolymers, medical products that contain such copolymers, and methods of making such medical products are also disclosed.

    摘要翻译： 提供医疗共聚物，其包含（a）聚合物主链，其包含（i）聚合物主链内的多个-C≡C-基团，（ii）聚合物主链内的多个-R9-基团，其中R9包含基团 - 取代的C 2 -C 10环状或杂环基团，或（iii）聚合物主链内的多个-C≡C-基团和多个-R9-基团，（b）多个基于烃基的侧基 包括长度为至少四个碳的饱和或不饱和碳链的聚合物主链，和（c）沿聚合物主链的多个两性离子侧基，其包含带正电荷的季铵基和带负电荷的磷酸基。 还公开了形成这种共聚物的方法，含有这些共聚物的医药产品，以及制造这种医药产品的方法。

    FIBROUS CONTAINMENT FOR HEMOSTASIS PLUG
    6.
    发明申请
    FIBROUS CONTAINMENT FOR HEMOSTASIS PLUG 审中-公开
    用于HEMOSTASIS PLUG的FIBROUS容纳

    公开(公告)号：US20120101525A1

    公开(公告)日：2012-04-26

    申请号：US13278910

    申请日：2011-10-21

    申请人： Mark L. Jenson ,  Jason P. Hill ,  James Q. Feng ,  David J. Sogard ,  Robert W. Warner ,  Patrick A. Haverkost

    发明人： Mark L. Jenson ,  Jason P. Hill ,  James Q. Feng ,  David J. Sogard ,  Robert W. Warner ,  Patrick A. Haverkost

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0057 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/06185

    摘要： A device for sealing an opening in a vessel includes an anchor attached to a suture. The anchor is inserted through the opening into the vessel, and the suture pulls the anchor against the vessel wall, forming a seal. A plug is inserted over the suture and is axially compressed toward the anchor, locking the elements in place. The suture is braided or woven outside of the anchor so that it may be stored and handled easily, and is unbraided, unwoven and/or untangled at its distal end inside the anchor, so that individual filaments within the suture may extend laterally within the anchor. The laterally extending filaments subtend a larger footprint within the anchor than a comparable footprint if the suture were to remain braided or tied into a knot within the anchor, which may more effectively distribute the retaining forces within the anchor.

    摘要翻译： 用于密封容器中的开口的装置包括附接到缝合线的锚固件。 锚固件通过开口插入容器中，并且缝合线将锚固件拉靠在血管壁上，形成密封。 将塞子插入缝合线上并朝向锚固件轴向压缩，将元件锁定就位。 该缝合线被编织或编织在锚定体之外，使得其可以容易地储存和处理，并且在其锚固体内部的远端处是未被覆盖的，无纺的和/或解开的，使得缝合线内的单个细丝可以在锚定件内横向延伸 。 横向延伸的长丝在锚固体内对着较大的覆盖区域，而不是如果缝合线保持编织或连接到锚固体内的结，这可以更有效地将锚定力分配在锚固体内。

    Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion
    7.
    发明授权
    Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion 失效
    用于递送治疗剂与电化学腐蚀的医疗装置

    公开(公告)号：US08114148B2

    公开(公告)日：2012-02-14

    申请号：US12489948

    申请日：2009-06-23

    申请人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    发明人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    IPC分类号： A61F2/82

    CPC分类号： A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.

    摘要翻译： 根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域， 第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。