-
公开(公告)号:US20140141034A1
公开(公告)日:2014-05-22
申请号:US14131150
申请日:2012-07-05
申请人: Roberto Adamo , Martin Allen , Francesco Berti , Elisa Danieli , Qi-Ying Hu
发明人: Roberto Adamo , Martin Allen , Francesco Berti , Elisa Danieli , Qi-Ying Hu
IPC分类号: A61K47/48
CPC分类号: A61K47/4833 , A61K39/385 , A61K47/51 , A61K47/54 , A61K47/549 , A61K47/593 , A61K47/62 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/505
摘要: A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A1) and an acid terminus end (A2) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.
摘要翻译: 提供了一种制备式(IA)或(I)的缀合物的方法,其包含分散在具有氨基酸链的氨基酸链和氨基末端末端的含有n个数量的酪氨酸单元的多肽,其中n为大于或等于1的整数 (A1)和所述蛋白质或多肽的酸性末端(A2),并且具有等于或大于10,000道尔顿(10kDa)的重均分子量,其中所述缀合物包含数量m的酪氨酸缀合物(修饰的酪氨酸残基) 如式(IA)或(I)所示,其中m为至少一个且小于或等于n:其中X,Lg,L和R如本文所定义。
-
公开(公告)号:US09149541B2
公开(公告)日:2015-10-06
申请号:US14131150
申请日:2012-07-05
申请人: Roberto Adamo , Martin Allen , Francesco Berti , Elisa Danieli , Qi-Ying Hu
发明人: Roberto Adamo , Martin Allen , Francesco Berti , Elisa Danieli , Qi-Ying Hu
CPC分类号: A61K47/4833 , A61K39/385 , A61K47/51 , A61K47/54 , A61K47/549 , A61K47/593 , A61K47/62 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/505
摘要: A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain having and amino terminus end (A1) and an acid terminus end (A2) of the protein or polypeptide and having a weight average molecular weight equal to or greater than 10,000 Daltons (10 kDa), wherein the conjugate comprises a number m of tyrosine conjugates (modified tyrosine residues) as depicted in Formula (I-A) or (I), where m is at least one and is less than or equal to n: where X, Lg, L and R are as defined herein.
摘要翻译: 提供了一种制备式(IA)或(I)的缀合物的方法,其包含分散在具有氨基酸链的氨基酸链和氨基末端末端的含有n个数量的酪氨酸单元的多肽,其中n为大于或等于1的整数 (A1)和蛋白质或多肽的酸性末端(A2),并且具有等于或大于10,000道尔顿(10kDa)的重均分子量,其中所述缀合物包含数量m的酪氨酸缀合物(修饰的酪氨酸残基) 如式(IA)或(I)所示,其中m为至少一个且小于或等于n:其中X,Lg,L和R如本文所定义。
-
公开(公告)号:US20130315959A1
公开(公告)日:2013-11-28
申请号:US13997017
申请日:2011-12-23
申请人: Paolo Costantino , Roberto Adamo , Maria Rosaria Romano , Elisa Danieli , Francesco Berti , Emilia Cappelliti , Luigi Lay
发明人: Paolo Costantino , Roberto Adamo , Maria Rosaria Romano , Elisa Danieli , Francesco Berti , Emilia Cappelliti , Luigi Lay
IPC分类号: A61K39/08
CPC分类号: A61K39/08 , A61K47/6415 , A61K47/646 , C07H15/04 , C07H15/18 , C08B37/0003 , C08B37/0006 , C08B37/006 , C12P19/04 , C12Y302/00
摘要: The invention provides a synthetic C. difficile PS-II cell wall saccharide. The invention also provides a process for purifying C. difficile PS-II saccharide from C. difficile bacterial cells resulting in reduced contamination. The saccharides may be used in vaccines, particularly as conjugates with carrier proteins.
摘要翻译: 本发明提供了一种合成艰难梭菌PS-II细胞壁糖。 本发明还提供了从艰难梭菌细菌细胞中纯化艰难梭菌PS-II糖的方法,导致污染减少。 糖类可以用于疫苗,特别是与载体蛋白质的缀合物。
-
-