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    Chiral ligand system for main group and transition metal catalysts
    2.
    发明授权
    Chiral ligand system for main group and transition metal catalysts 失效
    主要和过渡金属催化剂的手性配体体系

    公开(公告)号：US5981783A

    公开(公告)日：1999-11-09

    申请号：US58756

    申请日：1998-04-10

    申请人： Robin L. Polt

    发明人： Robin L. Polt

    IPC分类号： C07C251/24 ,  C07F15/04

    CPC分类号： C07D301/14 ,  C07C251/24

    摘要： A chiral ligand system for transition or main group metal catalysts is disclosed. These ligands can be readily synthesized using inexpensive amino acids and diamines as starting materials. Several different transition or main group metals have been inserted into the ligands. The ligands have been shown to have a tetradhedral distortion that may contribute to enhanced chiral transfer from the catalyst to the substrate in chemical modifications of olefins and other reactive substrates. These catalysts have been demonstrated to be effective in catalyzing epoxidation of a variety of substrates.

    摘要翻译： 公开了用于过渡金属或主族金属催化剂的手性配体体系。 这些配体可以使用廉价的氨基酸和二胺作为原料容易地合成。 已经将几种不同的过渡金属或主族金属插入配体中。 已经显示配体具有四面体变形，这可能有助于在烯烃和其它反应性底物的化学修饰中增强从催化剂到底物的手性转移。 已经证明这些催化剂有效催化各种底物的环氧化。

    Amphipathic glycopeptides
    3.
    发明授权
    Amphipathic glycopeptides 有权
    两亲性糖肽

    公开(公告)号：US07803764B2

    公开(公告)日：2010-09-28

    申请号：US10594515

    申请日：2005-03-25

    申请人： Robin L. Polt ,  Edward Bilsky

    发明人： Robin L. Polt ,  Edward Bilsky

    IPC分类号： A61K38/00 ,  A61K38/14 ,  C07K9/00

    CPC分类号： C07K14/575 ,  A61K38/08 ,  A61K38/10 ,  C07K9/001

    摘要： Amphipathic glycopeptides, the amino acid sequence of which comprises an N-terminal opioid message sequence, a C-terminal helical address sequence, and a linker sequence between the message sequence and the helical address sequence, where the C-terminal helical address sequence has a length of nine amino acids, and at least one of the amino acid residues of the peptide is glycosylated. The peptides are useful for relieving pain, providing analgesia and treating anxiety, depression, obesity, anorexia nervosa, phobias, schizophrenia, Parkinson's disease and Alzheimer's disease.

    摘要翻译： 两亲性糖肽，其氨基酸序列包含N-末端阿片样物质消息序列，C-末端螺旋地址序列和消息序列与螺旋地址序列之间的连接序列，其中C-末端螺旋地址序列具有 长度为九个氨基酸，并且肽的至少一个氨基酸残基被糖基化。 这些肽可用于缓解疼痛，提供止痛和治疗焦虑症，抑郁症，肥胖症，神经性厌食症，恐惧症，精神分裂症，帕金森病和阿尔茨海默病。

    Method for making amino acid glycosides and glycopeptides
    4.
    发明授权
    Method for making amino acid glycosides and glycopeptides 失效
    制备氨基酸糖苷和糖肽的方法

    公开(公告)号：US5470949A

    公开(公告)日：1995-11-28

    申请号：US990960

    申请日：1992-12-15

    申请人： Robin L. Polt

    发明人： Robin L. Polt

    IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K5/06 ,  C07K5/065 ,  C07K9/00 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

    CPC分类号： C07K9/001 ,  C07K1/006 ,  C07K5/0606 ,  C07K5/06078 ,  C07K9/00 ,  A61K38/00

    摘要： A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imidate ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar. G is a carbon chain of 0-10 carbons and R is not a methyl group and is a group capable of removal under conditions compatible with glycopeptide synthesis. In a preferred form the compound, R is selected from the group consisting of benzylic or allyl groups and X is CPh.sub.2. A method of forming a glycocide from the compound is also disclosed.

    摘要翻译： 公开了式（IMAGE）的化合物。 X选自芳基，烷基，亚氨酸酯，亚氨基酯，脒，叠氮化物，异氰酸酯和二硫代碳酸酯。 R'是选自含有羟基部分的基团，含有被保护的羟基部分的基团和含有O-连接的糖的基团的基团。 G是0-10个碳的碳链，R不是甲基，是能够与糖肽合成相容的条件下能除去的基团。 在优选形式的化合物中，R选自苄基或烯丙基，X是CPh2。 还公开了从化合物形成糖基化的方法。