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公开(公告)号：US20210215716A1
公开(公告)日：2021-07-15
申请号：US17181386
申请日：2021-02-22
Applicant: Roche Diagnostics Operations, Inc. , Universiteit Maastricht , Academisch Ziekenhuis Maastricht
Inventor： Peter Kastner , Manuel Dietrich , André Ziegler , Ursula-Henrike Wienhues-Thelen , Vinzent Rolny , Ulrich Schotten
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of SPON-1 in a sample from the subject, and comparing the amount of SPON-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for the prediction of stroke based on the amount of SPON-1.
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公开(公告)号：US20230095167A1
公开(公告)日：2023-03-30
申请号：US17801469
申请日：2021-02-19
Applicant: Universiteit Maastricht , Academisch Ziekenhuis Maastricht , Roche Diagnostics Operations, Inc.
Inventor： Alfred Engel , Michael Gerg , Ute Jucknischke , Johann Karl , Peter Kastner , Thomas Meier , Lars Hillringhaus , Ulrich Schotten , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , André Ziegler , Roberto Latini , Jennifer Marie Theresia Anna Meessen
Abstract: The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP10 in a sample from the subject, and comparing the amount of BMP10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP 10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP10-type peptide in a sample from a subject. The present invention further pertains to antibodies which bind to one or more BMP10-type peptides such as NT-proBMP10.
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公开(公告)号：US20230366894A1
公开(公告)日：2023-11-16
申请号：US18028235
申请日：2021-09-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Johann Karl , Peter Kastner , Roberto Latini , Serge Masson , Jennifer Marie Theresia Anna Meessen , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , André Ziegler
IPC: G01N33/74
CPC classification number: G01N33/74 , G01N2333/58 , G01N2440/38 , G01N2800/326
Abstract: The present invention relates to a method for diagnosing atrial fibrillation in a subject, said method comprising the steps of a) determining the amount of total NT-proBNP in sample from the subject, b) determining the amount of unglycosylated NT-proBNP in a sample from the subject, c) calculating a score of the amounts determined in steps a) and b), d) comparing the calculated score with a reference score, and e) diagnosing atrial fibrillation in a subject.
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公开(公告)号：US20230176077A1
公开(公告)日：2023-06-08
申请号：US17912776
申请日：2021-03-18
Applicant: Universiteit Maastricht , Academisch Ziekenhuis Maastricht , Roche Diagnostics Operations, Inc.
Inventor： Peter Kastner , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , André Ziegler , Manuel Dietrich , Ulrich Schotten
IPC: G01N33/68
CPC classification number: G01N33/6896 , G01N2800/2871 , G01N2800/326 , G01N2800/50 , G01N2333/9121
Abstract: The present invention relates to a method for aiding in the prediction of stroke and/or dementia in a subject, said method comprising a) determining the amount of the biomarker RET (Rearranged during transfection) in a sample from the subject, b) comparing the amount determined in step a) to a reference, and c) aiding in the prediction of stroke and/or dementia. The present invention further relates to a method for aiding in the assessment of the extent of white matter lesions in a subject, a method for aiding in the assessment whether a subject has experienced one or more silent strokes and to a method for aiding in the diagnosis of atrial fibrillation in a subject. Further encompassed by the present invention are the corresponding uses.
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