公开(公告)号：US08759081B2

公开(公告)日：2014-06-24

申请号：US13629905

申请日：2012-09-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Klaunick ,  Romi Roedl ,  Daniel Rohleder ,  Valerie Winckler-Desprez

IPC: C12M1/34 ,  B01L3/00

CPC classification number: B01L3/5027 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0851

Abstract: A test element, analytical system and method for optical analysis of fluid samples is provided. The test element has a substrate and a microfluidic channel structure, which is enclosed by the substrate and a cover layer. The channel structure has a measuring chamber with an inlet opening. The test element has a first level, which faces the cover layer, and a second level, which interconnects with the first level such that the first level is positioned between the cover layer and the second level. A part of the measuring chamber extending through the first level forms a measuring zone connecting with a part of the measuring chamber that extends partially into the second level, forming a mixing zone. Optical analysis of fluid samples is carried out by light guided through the first level parallel to the cover layer, such that the light traverses the measuring zone along an optical axis.

Abstract translation: 提供了一种用于流体样品的光学分析的测试元件，分析系统和方法。 测试元件具有衬底和微流体通道结构，其被衬底和覆盖层包围。 通道结构具有具有入口开口的测量室。 测试元件具有面向覆盖层的第一层和与第一层互连的第二层，使得第一层位于覆盖层和第二层之间。 延伸穿过第一级的测量室的一部分形成与部分地延伸到第二级中的测量室的一部分连接的测量区，形成混合区。 流体样品的光学分析通过平行于覆盖层的第一级引导的光进行，使得光沿着光轴穿过测量区。

公开(公告)号：US20130023060A1

公开(公告)日：2013-01-24

申请号：US13629905

申请日：2012-09-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Klaunik ,  Romi Roedl ,  Daniel Rohleder ,  Valerie Winckler-Desprez

IPC: G01N21/75

CPC classification number: B01L3/5027 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0851

Abstract: A test element, analytical system and method for optical analysis of fluid samples is provided. The test element has a substrate and a microfluidic channel structure, which is enclosed by the substrate and a cover layer. The channel structure has a measuring chamber with an inlet opening. The test element has a first level, which faces the cover layer, and a second level, which interconnects with the first level such that the first level is positioned between the cover layer and the second level. A part of the measuring chamber extending through the first level forms a measuring zone connecting with a part of the measuring chamber that extends partially into the second level, forming a mixing zone. Optical analysis of fluid samples is carried out by light guided through the first level parallel to the cover layer, such that the light traverses the measuring zone along an optical axis.

Abstract translation: 提供了一种用于流体样品的光学分析的测试元件，分析系统和方法。 测试元件具有衬底和微流体通道结构，其被衬底和覆盖层包围。 通道结构具有具有入口开口的测量室。 测试元件具有面向覆盖层的第一层和与第一层互连的第二层，使得第一层位于覆盖层和第二层之间。 延伸穿过第一级的测量室的一部分形成与部分地延伸到第二级中的测量室的一部分连接的测量区，形成混合区。 流体样品的光学分析通过平行于覆盖层的第一级引导的光进行，使得光沿着光轴穿过测量区。