公开(公告)号：US11740254B2

公开(公告)日：2023-08-29

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro Ota ,  Takaaki Hagiwara ,  Yoshihiro Yamashita ,  Koshin Hamasaki ,  Michaela Windfuhr ,  Heike Guggemos ,  Johannes Stoeckel ,  Guenter Ziegler ,  Michael Kuehnl

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  G01N35/1016 ,  G01N2035/1025

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US11125601B2

公开(公告)日：2021-09-21

申请号：US16226889

申请日：2018-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Guenter Ziegler ,  Oliver Larbolette ,  Rolf Herb

IPC: G01F23/292 ,  G01F23/14 ,  G01F23/24 ,  G01F23/26 ,  G01N35/10

Abstract: An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the secure and reliable pipetting of the laboratory sample in response to both the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.

公开(公告)号：US20190120682A1

公开(公告)日：2019-04-25

申请号：US16226889

申请日：2018-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Guenter Ziegler ,  Oliver Larbolette ,  Rolf Herb

IPC: G01F23/292 ,  G01N35/10

Abstract: An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the processing of the laboratory sample in response to the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.

公开(公告)号：US10101085B2

公开(公告)日：2018-10-16

申请号：US14605107

申请日：2015-01-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Juergen Dittrich ,  Guenter Ziegler

IPC: F26B5/06 ,  A61K9/19 ,  F25C1/10 ,  F25C1/16

Abstract: The invention relates to an apparatus and a method of freezing a liquid substance contained in at least one receptacle, comprising the steps of: providing the liquid substance in at least one receptacle, providing a cooling chamber and a cooling device having a cooling surface; setting the temperature of the cooling surface, starting a freezing procedure by placing the receptacle with the liquid substance therein on the cooling surface to form a seed or initial zone of nucleation; and continuing the freezing procedure to completely freeze the substance.