公开(公告)号：US12085563B2

公开(公告)日：2024-09-10

申请号：US17311864

申请日：2019-12-20

申请人： Kenota Inc.

发明人： Christopher J. Harder ,  David Andrew McMullin ,  Eric Blondeel ,  Kien Vu

IPC分类号： G01N21/05 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N33/54388 ,  G01N21/05 ,  G01N35/1009 ,  G01N35/1065 ,  G01N35/1081 ,  G01N2035/00356 ,  G01N2035/00455 ,  G01N2035/1025

摘要： Described is a lateral flow high throughput assay device analyzer for preparing and analyzing a plurality of lateral flow assay samples. The analyzer comprises a cartridge stage for supporting an assay cartridge, an elevation adjustment mechanism, and a translation adjustment mechanism for aligning the cartridge stage and assay cartridge relative to a vertical support structure, fluid metering device, and detection device for high throughput lateral flow assay analysis.

公开(公告)号：US20240264192A1

公开(公告)日：2024-08-08

申请号：US18428022

申请日：2024-01-31

申请人： CANON MEDICAL SYSTEMS CORPORATION

发明人： Tetsushi YAMAMOTO ,  Tatsuya MURATA ,  Tomio NABATAME ,  Kenji YAMASAKI ,  Tomomi MURAMATSU

IPC分类号： G01N35/10 ,  G01N35/02 ,  G06V20/52

CPC分类号： G01N35/1011 ,  G01N35/026 ,  G01N35/1079 ,  G01N2035/1025 ,  G06V20/52

摘要： An automatic analyzing apparatus according to the present embodiment comprises a first imager configured to image a sample container in which a sample is contained and whose upper surface is sealed with a cap; and processing circuitry configured to acquire a liquid level height of the sample contained in the sample container based on first image data of the sample container imaged by the first imager; and determine, based on the liquid level height, a first parameter related to a descent operation of a piercing arm, and controls, based on the first parameter, the descent operation of the piercing arm, and the piercing arm holding a piercer needle for piercing the cap of the sample container.

公开(公告)号：US20240159789A1

公开(公告)日：2024-05-16

申请号：US18548552

申请日：2021-12-03

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Yuichi Iwase ,  Takushi Miyakawa ,  Shunsuke Miyamoto ,  Masafumi Miyake

IPC分类号： G01N35/10 ,  B01L3/02

CPC分类号： G01N35/1016 ,  B01L3/0293 ,  B01L2200/143 ,  B01L2300/027 ,  B01L2300/0645 ,  G01N2035/1025

摘要： The present invention enables automatic detection of failure in a plunger in a syringe pump unit by an automated analysis device, which includes a sample dispensing mechanism; a reagent dispensing mechanism; and a control unit for controlling operation of the sample dispensing mechanism and the reagent dispensing mechanism and analyzing the sample. The sample dispensing mechanism and the reagent dispensing mechanism each have a plunger for suctioning in and expelling liquid, and a plunger drive unit for driving the plunger. The control unit controls operation with the plunger drive unit of the reagent dispensing mechanism so that the plunger moves reciprocally by a backlash distance a predetermined number of times. Failure of the plunger is detected by detecting, using the liquid level sensing function, the amount of liquid discharged into the liquid storage container.

公开(公告)号：US20240110936A1

公开(公告)日：2024-04-04

申请号：US18267839

申请日：2020-12-21

申请人： TECAN TRADING AG

发明人： Peter MUERSET

IPC分类号： G01N35/10 ,  G01N35/00

CPC分类号： G01N35/1016 ,  G01N35/00623 ,  G01N2035/1025

摘要： A method for minimizing the dead volume (Vd) in a vial (10) presenting a liquid (L) for aspiration is provided. The method comprises, after determining that the liquid volume (Vi) indicated to be available in the vial (10) is not sufficient for a further aspiration step, moving downward in direction towards the bottom of the vial (10) by means of a pipetting arm (20) presenting a pipetting tip (21) and along the z-axis of the pipetting arm (20) until the pipetting arm (20) comes to a stop in a first stop position (S1z). Then, the actual available liquid volume (Va) is calculated based i.a. on said first stop position (S1z). In case the calculated actual available liquid volume (Va) is sufficient, a further aspiration step can be executed. Furthermore, a liquid handling system for minimizing dead volume (Vd), a computer-implemented method for controlling a pipetting arm (20) of such a liquid handling system, and the use of a hysteresis determination method for minimizing dead volume (Vd) are provided.

公开(公告)号：US20240085445A1

公开(公告)日：2024-03-14

申请号：US18265565

申请日：2021-12-09

申请人： bioMérieux

发明人： Andrea CARIGNANO ,  Gionatan CARADONNA ,  Andrea TRAVERSI ,  Marco SALVADORI

IPC分类号： G01N35/10 ,  G06T7/00 ,  G06T7/73 ,  G06T7/90

CPC分类号： G01N35/1011 ,  G06T7/0014 ,  G06T7/73 ,  G06T7/90 ,  G01N2035/1025 ,  G06T2207/30024

摘要： Detection method for sample presence and device associated The invention relates to a detection method of liquid presence inside a well of a transparent or translucent support intended for analysis performed in a device for in vitro detection and/or quantification, the presence of liquid being assessed on the basis of an index of visible pattern likelihood representative of the probability of a pattern to be legible as expected in the field of view of an imager. Said invention allows preventing assay execution without sample and can be applied without wasting sample or sample well support in case of the sample well is not filled by the user. Moreover, this method allows a precise detection of the samples that are transparent or translucent, with low reflectance.

公开(公告)号：US20240061000A1

公开(公告)日：2024-02-22

申请号：US18450584

申请日：2023-08-16

申请人： Canon Medical Systems Corporation

发明人： Atsushi HOSOOKA ,  Mitsuo OKAMOTO ,  Naoto SATO ,  Masaaki SAITOU ,  Reiko MARUYAMA ,  Yuki MATSUMOTO ,  Kensuke OKUGI

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00663 ,  G01N35/1009 ,  G01N2035/00396 ,  G01N2035/1025

摘要： According to one embodiment, an automatic analyzing apparatus includes processing circuitry. The processing circuitry measures an electrical potential pertaining to a contact between a probe for dispensing a sample or a reagent and a liquid surface, and outputs the measured electrical potential as a measurement value, determines whether or not the measurement value is within a specific range, and outputs a determination result, and provides a notification on a state of a liquid related to the liquid surface according to the determination result.

公开(公告)号：US11906346B2

公开(公告)日：2024-02-20

申请号：US17268705

申请日：2019-08-22

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Fumiyasu Sato ,  Masahito Kakuno ,  Nobuyoshi Shimane

IPC分类号： G01F23/292 ,  G01N35/10

CPC分类号： G01F23/292 ,  G01N35/1009 ,  G01N2035/1025

摘要： A liquid level detection device capable of accurately detecting an interface inside a container has an irradiation unit which irradiates a side surface of a sample container containing a sample having layers with light. A light receiving unit receives transmitted light from the sample container and an analysis unit acquires the interfaces between the layers from the received amount of the transmitted light. The sample container is moved vertically relative to the irradiation unit and the light receiving unit by a first drive and is moved in the circumferential direction relative to the irradiation unit and the light receiving unit by a second drive. The second drive is controlled so that the light receiving unit receives the transmitted light at first and second irradiation angles, and the interfaces between the layers are acquired on the basis of the received amounts of transmitted light at the first and second irradiation angles.

公开(公告)号：US11892455B2

公开(公告)日：2024-02-06

申请号：US17061095

申请日：2020-10-01

申请人： Meso Scale Technologies, LLC

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC分类号： G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B01L3/00 ,  G01N35/04

CPC分类号： G01N33/582 ,  B01L3/5085 ,  B01L3/50255 ,  B67B7/24 ,  G01N21/6452 ,  G01N21/66 ,  G01N33/5302 ,  G01N35/028 ,  G01N35/1011 ,  G01N35/1079 ,  G01N35/1081 ,  G01N35/1002 ,  G01N35/109 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1025 ,  Y10T83/9314

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US11885826B2

公开(公告)日：2024-01-30

申请号：US17118833

申请日：2020-12-11

申请人： SHIMADZU CORPORATION

发明人： Takanori Onoki ,  Kiyohiro Sugiyama

IPC分类号： G01N35/10 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N35/1079 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2035/0444 ,  G01N2035/1025

摘要： A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.

公开(公告)号：US11761971B2

公开(公告)日：2023-09-19

申请号：US16725881

申请日：2019-12-23

申请人： Joachim Gerstel

发明人： Joachim Gerstel

IPC分类号： G01N35/02 ,  G01N35/10 ,  G01N1/28 ,  B01L3/02 ,  B01D35/02 ,  B04B5/04 ,  B01F25/10 ,  B04B11/04 ,  G01N35/00 ,  G01N35/04 ,  B01F101/23

CPC分类号： G01N35/025 ,  B01D35/02 ,  B01F25/10 ,  B01L3/0275 ,  B04B5/0414 ,  B04B5/0421 ,  B04B11/043 ,  G01N1/286 ,  G01N35/00732 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1011 ,  G01N35/1079 ,  B01F2101/23 ,  B01L2300/0681 ,  B04B2011/046 ,  G01N35/1097 ,  G01N2001/2873 ,  G01N2035/0405 ,  G01N2035/0449 ,  G01N2035/103 ,  G01N2035/1025 ,  G01N2035/1053

摘要： The invention relates to an arrangement for preparing a plurality of samples for an analytical method, comprising a carousel with a solid housing and moveable receiving parts for the sample containers; a control for controlling the receiving parts in the carousel; and a sample receiving device for providing the sample for the analytical method. Said arrangement is characterized in that one or more stations for preparing samples are provided on the carousel, the receiving parts for the sample containers of the carousel can be positioned on said stations. Said arrangement also comprises a centrifuge with pairs of opposite lying receiving parts provided for the sample containers, and said receiving parts are arranged such that they can move on the centrifuge for the sample holder such that a transfer of a sample holder between a receiving part in the carousel and a receiving part in the centrifuge can be carried out. The control takes place by the same control which is also provided for controlling the carousel.