公开(公告)号：US11249059B2

公开(公告)日：2022-02-15

申请号：US16994118

申请日：2020-08-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Benjamin Tiemann ,  Florian Schweinberger ,  Martin Stingl

IPC: G01N30/72 ,  G01N30/86 ,  H01J49/00 ,  H01J49/16 ,  G01N35/10 ,  H01J49/04 ,  G01N30/62 ,  G01N15/12 ,  G01N30/04

Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.

公开(公告)号：US20210063361A1

公开(公告)日：2021-03-04

申请号：US16994118

申请日：2020-08-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Benjamin Tiemann ,  Florian Schweinberger ,  Martin Stingl

IPC: G01N30/72 ,  G01N30/86 ,  H01J49/16 ,  H01J49/00

Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.