公开(公告)号：US20220011301A1

公开(公告)日：2022-01-13

申请号：US17292660

申请日：2019-11-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank BERGMANN ,  Dieter HEINDL ,  Tobias OELSCHLAEGEL ,  Johannes STOECKEL

IPC: G01N33/543

Abstract: The present disclosure relates to a solid phase coated with (strept)avidin and having attached thereto, by way of biotin:(strept)avidin interaction, a biotinylated first member of a binding pair, wherein the attached first member is capable of binding to a second member of the binding pair, but is not capable of binding to biotin or to (strept)avidin, and wherein no member of the binding pair is capable of hybridizing with a naturally-occurring single-stranded nucleic acid. The solid phase is particularly useful in immunoassays with samples having high content in biotin or (strept)avidin-binding derivatives thereof. The present disclosure further provides uses, kits and methods, particularly for determination of an analyte in a sample.

公开(公告)号：US20220169664A1

公开(公告)日：2022-06-02

申请号：US17588884

申请日：2022-01-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter JOSEL ,  Tobias OELSCHLAEGEL ,  Giuseppe PRENCIPE ,  Luisa DE COLA ,  Elena LONGHI ,  Chien-Wei HSU

IPC: C07F7/08 ,  C09K11/06

Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.