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公开(公告)号:US20180273643A1
公开(公告)日:2018-09-27
申请号:US15918034
申请日:2018-03-12
申请人: Roche Glycart AG
发明人: Oliver AST , Peter BRUENKER , Tanja FAUTI , Anne FREIMOSER-GRUNDSCHOBER , Christiane Neumann , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA
CPC分类号: C07K16/468 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.