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公开(公告)号:US10040843B2
公开(公告)日:2018-08-07
申请号:US15140414
申请日:2016-04-27
申请人: Roche Glycart AG
发明人: Lydia Jasmin Duerner , Thomas Emrich , Jens Fischer , Ralf Hosse , Ekkehard Moessner , Pablo Umana , Daigen Xu
摘要: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
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公开(公告)号:US20140044674A1
公开(公告)日:2014-02-13
申请号:US13959051
申请日:2013-08-05
申请人: Roche Glycart AG
发明人: Lydia Jasmin Duerner , Thomas Emrich , Jens Fischer , Ralf Hosse , Ekkehard Moessner , Pablo Umana , Daigen Xu
CPC分类号: C07K16/00 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/92 , C07K2319/00
摘要: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
摘要翻译: 本发明一般涉及抗体和白细胞介素-10(IL-10)的融合蛋白。 此外,本发明涉及编码这种融合蛋白的多核苷酸,以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的融合蛋白的制备方法及其在治疗疾病中的应用。
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公开(公告)号:US20160340413A1
公开(公告)日:2016-11-24
申请号:US15140414
申请日:2016-04-27
申请人: Roche Glycart AG
发明人: Lydia Jasmin Duerner , Thomas Emrich , Jens Fischer , Ralf Hosse , Ekkehard Moessner , Pablo Umana , Daigen Xu
CPC分类号: C07K16/00 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/92 , C07K2319/00
摘要: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
摘要翻译: 本发明一般涉及抗体和白细胞介素-10(IL-10)的融合蛋白。 此外,本发明涉及编码这种融合蛋白的多核苷酸,以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的融合蛋白的制备方法及其在治疗疾病中的应用。
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公开(公告)号:US09346872B2
公开(公告)日:2016-05-24
申请号:US13959051
申请日:2013-08-05
申请人: Roche Glycart AG
发明人: Lydia Jasmin Duerner , Thomas Emrich , Jens Fischer , Ralf Hosse , Ekkehard Moessner , Pablo Umana , Daigen Xu
CPC分类号: C07K16/00 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/92 , C07K2319/00
摘要: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
摘要翻译: 本发明一般涉及抗体和白细胞介素-10(IL-10)的融合蛋白。 此外,本发明涉及编码这种融合蛋白的多核苷酸,以及包含这种多核苷酸的载体和宿主细胞。 本发明还涉及本发明的融合蛋白的制备方法及其在治疗疾病中的应用。
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