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    Nanopore-based sequencing with varying voltage stimulus
    1.
    发明授权
    Nanopore-based sequencing with varying voltage stimulus 有权

    公开(公告)号：US12228539B2

    公开(公告)日：2025-02-18

    申请号：US17447048

    申请日：2021-09-07

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  J. William Maney, Jr. ,  Hui Tian

    IPC: G01N27/22 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

    Exporting measurements of nanopore arrays
    2.
    发明授权
    Exporting measurements of nanopore arrays 有权

    公开(公告)号：US11549935B2

    公开(公告)日：2023-01-10

    申请号：US16892214

    申请日：2020-06-03

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  Santiago Fernandez-Gomez ,  Hui Tian

    IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y15/00

    Abstract: A method of exporting measurements of a nanopore sensor on a nanopore based sequencing chip is disclosed. An electrical characteristic associated with the nanopore sensor is measured. The electrical characteristic associated with the nanopore sensor is processed. A summary for the electrical characteristic and one or more previous electrical characteristics is determined. The summary for the electrical characteristic and the one or more previous electrical characteristics are exported. Determining the summary includes determining that the electrical characteristic and at least a portion of the one or more previous electrical characteristics correspond to a base call event at the nanopore sensor. The summary represents the electrical characteristic and the at least a portion of the one or more previous electrical characteristics.

    Nanopore-based sequencing with varying voltage stimulus
    5.
    发明授权
    Nanopore-based sequencing with varying voltage stimulus 有权

    公开(公告)号：US10545112B2

    公开(公告)日：2020-01-28

    申请号：US15820032

    申请日：2017-11-21

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  Hui Tian ,  J. William Maney, Jr.

    IPC: G01N27/447 ,  G01N27/22 ,  C12Q1/6869 ,  G01N33/487

    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

    Nanopore-based sequencing with varying voltage stimulus
    6.
    发明授权
    Nanopore-based sequencing with varying voltage stimulus 有权

    公开(公告)号：US11112375B2

    公开(公告)日：2021-09-07

    申请号：US16719774

    申请日：2019-12-18

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  J. William Maney, Jr. ,  Hui Tian

    IPC: G01N27/22 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

    ADJUSTABLE BILAYER CAPACITANCE STRUCTURE FOR BIOMEDICAL DEVICES
    7.
    发明申请
    ADJUSTABLE BILAYER CAPACITANCE STRUCTURE FOR BIOMEDICAL DEVICES 审中-公开

    公开(公告)号：US20200264160A1

    公开(公告)日：2020-08-20

    申请号：US16868457

    申请日：2020-05-06

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J.A. Chen ,  Jennifer Hovis ,  Hui Tian

    IPC: G01N33/487

    Abstract: A nanopore sequencing device is disclosed. The nanopore sequencing device includes a working electrode. It further includes a dielectric layer, wherein a portion of the dielectric layer is disposed horizontally adjacent to the working electrode and a portion of the dielectric layer is disposed above and covering a portion of the working electrode, and wherein the dielectric layer forms a well having an opening above an uncovered portion of the working electrode. A base surface area of the working electrode is greater than a base surface area of the opening above the uncovered portion of the working electrode.

    Exporting measurements of nanopore arrays
    8.
    发明授权
    Exporting measurements of nanopore arrays 有权

    公开(公告)号：US10677776B2

    公开(公告)日：2020-06-09

    申请号：US16046931

    申请日：2018-07-26

    Applicant: Roche Sequencing Solutions, Inc.

    Inventor： Roger J. A. Chen ,  Hui Tian ,  Santiago Fernandez-Gomez

    IPC: G01N27/447 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y15/00

    Abstract: A method of exporting measurements of a nanopore sensor on a nanopore based sequencing chip is disclosed. An electrical characteristic associated with the nanopore sensor is measured. The electrical characteristic associated with the nanopore sensor is processed. A summary for the electrical characteristic and one or more previous electrical characteristics is determined. The summary for the electrical characteristic and the one or more previous electrical characteristics are exported. Determining the summary includes determining that the electrical characteristic and at least a portion of the one or more previous electrical characteristics correspond to a base call event at the nanopore sensor. The summary represents the electrical characteristic and the at least a portion of the one or more previous electrical characteristics.

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