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94 条记录 (耗时 0.023 秒)

    1,2,3,5-Tetrahydro-4H-1,5-benzodiazepine-4-ones
    7.
    发明授权
    1,2,3,5-Tetrahydro-4H-1,5-benzodiazepine-4-ones 失效
    1,2,3,5-四氢-4H- 1,5-BENZODIAZEPINE-4-ONES

    公开(公告)号：US4111931A

    公开(公告)日：1978-09-05

    申请号：US874074

    申请日：1978-02-01

    申请人： Armin Walser ,  Rodney Ian Fryer

    发明人： Armin Walser ,  Rodney Ian Fryer

    IPC分类号： A61K31/55 ,  A61P21/02 ,  A61P25/20 ,  C07D243/12 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D243/12 ,  Y10S514/906

    摘要： The present invention concerns compounds of the formula ##STR1## wherein X is hydrogen or halogen; R.sub.1 is hydrogen, halogen or trifluoromethyl; R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is hydrogen, --COO lower alkyl or CON(R.sub.4).sub.2 wherein R.sub.2 is lower alkyl or hydrogen and may be differentand the pharmaceutically acceptable salts thereof.Also provided are methods for the preparation of these compounds as well as pharmaceutical formulations which contain the active compounds of this invention. The compounds of the formula illustrated above are useful as anxiolytics, anticonvulsants, muscle relaxants and sedative agents.

    Imidazo [1,5-a][1,5] benzodiazepines
    9.
    发明授权
    Imidazo [1,5-a][1,5] benzodiazepines 失效
    咪唑并[8,1-a {9 {8,5 {9 {苯并二氮杂

    公开(公告)号：US4080323A

    公开(公告)日：1978-03-21

    申请号：US775347

    申请日：1977-03-07

    申请人： Armin Walser ,  Rodney Ian Fryer

    发明人： Armin Walser ,  Rodney Ian Fryer

    IPC分类号： A61K31/55 ,  A61P21/02 ,  A61P25/20 ,  C07D243/12 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D243/12 ,  Y10S514/906

    摘要： The present invention concerns compounds of the formula ##STR1## wherein X is hydrogen or halogen; R.sub.1 is hydrogen, halogen or trifluoromethyl; R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is hydrogen, --COO lower alkyl or CON(R.sub.4).sub.2 wherein R.sub.4 is lower alkyl or hydrogen and may be differentAnd the pharmaceutically acceptable salts thereof.Also provided are methods for the preparation of these compounds as well as pharmaceutical formulations which contain the active compounds of this invention. The compounds of the formula illustrated above are useful as anxiolytics, anticonvulsants, muscle relaxants and sedative agents.

    摘要翻译： 本发明涉及下式的化合物，其中X是氢或卤素; R1是氢，卤素或三氟甲基; R2是氢或低级烷基; 并且R 3是氢，-COO低级烷基或CON（R 4）2，其中R 4是低级烷基或氢，并且可以是不同的，并且其药学上可接受的盐。

    7-Azoxy substituted-1,4-benzodiazepin-2-ones
    10.
    发明授权
    7-Azoxy substituted-1,4-benzodiazepin-2-ones 失效
    7-氮氧基取代的-1,4-苯并二氮杂-2-酮

    公开(公告)号：US3989681A

    公开(公告)日：1976-11-02

    申请号：US419582

    申请日：1973-11-28

    申请人： Rodney Ian Fryer ,  Armin Walser

    发明人： Rodney Ian Fryer ,  Armin Walser

    IPC分类号： C07D243/26 ,  C07C107/04

    CPC分类号： Y10S514/906

    摘要： Novel 1,4-benzodiazepin-2-ones of the formula ##SPC1##WhereinR.sub.1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl-lower alkyl, hydroxylower alkyl, lower alkoxy-lower alkyl and di-lower alkylamino-lower alkyl;R.sub.2 signifies hydrogen or lower alkyl; R.sub.3 signifies hydrogen or halogen; R.sub.4 signifies lower alkylAnd the pharmaceutically acceptable acid addition salts thereof, are disclosed together with processes for preparing these compounds and novel intermediates used in these processes. These 7-azoxy substituted-1,4-benzodiazepin-2-ones are useful as muscle relaxant, anti-convulsant and sedative agents.

    摘要翻译： 新颖的1,4-苯并二氮杂-2-酮，式WHEREIN R1选自氢，低级烷基，环烷基 - 低级烷基，羟基低级烷基，低级烷氧基 - 低级烷基和二 - 低级烷基氨基 - 低级烷基; R2表示氢或低级烷基; R3表示氢或卤素; R4表示低级烷基和其药学上可接受的酸的添加剂，与制备这些化合物和在这些方法中使用的新型中间体的方法无关。 这些7-氧杂取代的1,4-苯并二氮杂-2-酮可用作肌肉松弛剂，抗惊厥剂和镇静剂。