Cultures with Improved Phage Resistance
    2.
    发明申请
    Cultures with Improved Phage Resistance 审中-公开
    具有改进的抗药性的培养物

    公开(公告)号:US20110002889A1

    公开(公告)日:2011-01-06

    申请号:US12529421

    申请日:2008-02-29

    摘要: The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.

    摘要翻译: 本发明提供了与调节细胞对靶核酸或其转录产物的抗性相关的方法和组合物。 在一些优选实施方案中,本发明提供了使用一种或多种cas基因或蛋白质调节细胞对靶核酸或其转录产物的抗性的组合物和方法。 在一些实施方案中,本发明提供了用于开发和使用菌株组合和起始培养旋转的方法和组合物。 在另外的实施方案中,本发明提供用于标记和/或鉴定细菌的方法。 在一些优选的实施方案中,本发明提供了使用CRISPR基因座确定噬菌体对细胞的潜在毒力的方法,以及使用CRISPR-cas调节噬菌体的遗传序列以增加毒力水平。 在另外的实施方案中,本发明提供用于开发和使用噬菌体作为生物防治剂的方法和组合物。

    CULTURES WITH IMPROVED PHAGE RESISTANCE
    6.
    发明申请
    CULTURES WITH IMPROVED PHAGE RESISTANCE 有权
    具有改善抗药性的文化

    公开(公告)号:US20150093473A1

    公开(公告)日:2015-04-02

    申请号:US14570994

    申请日:2014-12-15

    IPC分类号: C12N15/74 A23C9/123

    摘要: The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.

    摘要翻译: 本发明提供了与调节细胞对靶核酸或其转录产物的抗性相关的方法和组合物。 在一些优选实施方案中,本发明提供了使用一种或多种cas基因或蛋白质调节细胞对靶核酸或其转录产物的抗性的组合物和方法。 在一些实施方案中,本发明提供了用于开发和使用菌株组合和起始培养旋转的方法和组合物。 在另外的实施方案中,本发明提供用于标记和/或鉴定细菌的方法。 在一些优选的实施方案中,本发明提供了使用CRISPR基因座确定噬菌体对细胞的潜在毒力的方法,以及使用CRISPR-cas调节噬菌体的遗传序列以增加毒力水平。 在另外的实施方案中,本发明提供用于开发和使用噬菌体作为生物防治剂的方法和组合物。

    Tagged microorganisms and methods of tagging
    7.
    发明申请
    Tagged microorganisms and methods of tagging 有权
    标签微生物和标记方法

    公开(公告)号:US20080124725A1

    公开(公告)日:2008-05-29

    申请号:US11804550

    申请日:2007-05-18

    IPC分类号: C12Q1/68 C12N1/21

    摘要: The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus Streptococcus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using the methods set forth herein. In some preferred embodiments, the tagged microorganisms are bacteria. In some particularly preferred embodiments, the tagged bacteria are members of the genus Streptococcus, while in other embodiments, the tagged bacteria are members of other genera.

    摘要翻译: 本发明提供了用于标记和/或识别微生物的方法。 在一些优选的实施方案中,微生物是细菌。 在一些特别优选的实施方案中,细菌是链球菌属的成员,而在其它实施方案中,细菌是其他属的成员。 本发明还提供使用本文所述方法标记的微生物。 在一些优选的实施方案中,标记的微生物是细菌。 在一些特别优选的实施方案中,标记的细菌是链球菌属的成员,而在其他实施方案中,标记的细菌是其他属的成员。

    Tagged microorganisms and methods of tagging
    9.
    发明授权
    Tagged microorganisms and methods of tagging 有权
    标签微生物和标记方法

    公开(公告)号:US09399801B2

    公开(公告)日:2016-07-26

    申请号:US11804550

    申请日:2007-05-18

    IPC分类号: C12Q1/68 C12Q1/70

    摘要: The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus Streptococcus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using the methods set forth herein. In some preferred embodiments, the tagged microorganisms are bacteria. In some particularly preferred embodiments, the tagged bacteria are members of the genus Streptococcus, while in other embodiments, the tagged bacteria are members of other genera.

    摘要翻译: 本发明提供了用于标记和/或识别微生物的方法。 在一些优选的实施方案中,微生物是细菌。 在一些特别优选的实施方案中,细菌是链球菌属的成员,而在其它实施方案中,细菌是其他属的成员。 本发明还提供使用本文所述方法标记的微生物。 在一些优选的实施方案中,标记的微生物是细菌。 在一些特别优选的实施方案中,标记的细菌是链球菌属的成员,而在其他实施方案中,标记的细菌是其他属的成员。

    Tagged Microorganisms and Methods of Tagging
    10.
    发明申请
    Tagged Microorganisms and Methods of Tagging 有权
    标签微生物和标记方法

    公开(公告)号:US20100104690A1

    公开(公告)日:2010-04-29

    申请号:US12225852

    申请日:2007-05-18

    摘要: The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus Streptococcus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using the methods set forth herein. In some preferred embodiments, the tagged microorganisms are bacteria. In some particularly preferred embodiments, the tagged bacteria are members of the genus Streptococcus, while in other embodiments, the tagged bacteria are members of other genera.

    摘要翻译: 本发明提供了用于标记和/或识别微生物的方法。 在一些优选的实施方案中,微生物是细菌。 在一些特别优选的实施方案中,细菌是链球菌属的成员,而在其它实施方案中,细菌是其他属的成员。 本发明还提供使用本文所述方法标记的微生物。 在一些优选的实施方案中,标记的微生物是细菌。 在一些特别优选的实施方案中,标记的细菌是链球菌属的成员,而在其他实施方案中,标记的细菌是其他属的成员。