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公开(公告)号：US06462182B1
公开(公告)日：2002-10-08
申请号：US09616658
申请日：2000-07-14
IPC分类号： C07H1500
摘要： Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.
摘要翻译： 描述了连接一个或多个碳水化合物单元的夫西地酸的新型类似物。 与未修饰的夫西地酸相比，夫西地酸的某些糖基化类似物具有增强的稀释剂或赋形剂的溶解性。 某些糖基化类似物可用作化学治疗剂，特定的类似物可用于抗菌抗感染。
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公开(公告)号：US6103884A
公开(公告)日：2000-08-15
申请号：US623335
申请日：1996-03-27
摘要： Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.
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公开(公告)号：US06720307B2
公开(公告)日：2004-04-13
申请号：US10189242
申请日：2002-07-02
IPC分类号： A61K3170
摘要： Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.
摘要翻译： 描述了连接一个或多个碳水化合物单元的夫西地酸的新型类似物。 与未修饰的夫西地酸相比，夫西地酸的某些糖基化类似物具有增强的稀释剂或赋形剂的溶解性。 某些糖基化类似物可用作化学治疗剂，特定的类似物可用于抗菌感染。
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公开(公告)号：US5932709A
公开(公告)日：1999-08-03
申请号：US876824
申请日：1997-06-16
申请人： Brian Keith Shull , Clarke Slemon , Masato Koreeda
发明人： Brian Keith Shull , Clarke Slemon , Masato Koreeda
摘要： The present invention relates to chemotherapeutic agents, and more particularly, to novel analogs of camptothecin. The camptothecin analogs display increased solubility through the hydrophilicity of added non-ionic sugar substituents. In accordance with the present invention, a member from the class of novel camptothecin analogs is to be delivered in vivo as a chemotherapeutic agent to fight cancer growth in the body.
摘要翻译： 本发明涉及化学治疗剂，更具体地涉及喜树碱的新型类似物。 喜树碱类似物通过添加的非离子糖取代基的亲水性显示增加的溶解度。 根据本发明，来自新兴喜树碱类似物类的成员将作为化学治疗剂在体内递送以抵抗体内的癌症生长。
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5.发明申请Compositions, Methods For Preparing Amino Acids And Nuclear Magnetic Resonance Spectroscopy 审中-公开组成，制备氨基酸和核磁共振光谱的方法公开(公告)号：US20110104076A1
公开(公告)日：2011-05-05
申请号：US13004321
申请日：2011-01-11
申请人： Brian Keith Shull
发明人： Brian Keith Shull
IPC分类号： A61B5/055 , C07C229/28
CPC分类号： A61K49/10 , C07B55/00 , C07B59/004 , C07F5/025
摘要： The present invention relates to amino acids, complexes, and compounds comprising deuterium and tritium isotopes preferably alpha deuterated amino acids, polypeptides, antibodies, derivatives and saccharide-amino acid complexes and conjugates. In some embodiments, the invention relates to methods of using compounds comprising deuterium for imaging biochemical concentrations and distributions in mammalian tissues using nuclear magnetic resonance spectroscopy. In some embodiments, the invention relates to the used of said amino acids derivatives and complexes in boron neutron capture therapy. In some embodiments, the present invention relates to the preparation of amino acids, polypeptides, antibodies, derivatives and saccharide complexes/conjugates comprising heavy hydrogen isotopes. In some embodiments, the invention relates to racemizing amino acids starting from compositions of any optical purity. In further embodiments, the invention relates to the preparation of amino acids and their N-acyl counterparts with deuterium incorporated at the alpha carbon.
摘要翻译： 本发明涉及包含氘和氚同位素的氨基酸，复合物和化合物，优选α氘代氨基酸，多肽，抗体，衍生物和糖 - 氨基酸复合物和缀合物。 在一些实施方案中，本发明涉及使用包含氘的化合物以使用核磁共振光谱法来测量哺乳动物组织中的生物化学浓度和分布的方法。 在一些实施方案中，本发明涉及在硼中子捕获治疗中使用所述氨基酸衍生物和复合物。 在一些实施方案中，本发明涉及包含重氢同位素的氨基酸，多肽，抗体，衍生物和糖配合物/缀合物的制备。 在一些实施方案中，本发明涉及从任何光学纯度的组合物开始的消旋化氨基酸。 在进一步的实施方案中，本发明涉及氨基酸及其N-酰基对应物的制备，其具有掺入α碳的氘。
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公开(公告)号：US07517891B2
公开(公告)日：2009-04-14
申请号：US11588021
申请日：2006-10-26
申请人： Brian Keith Shull
发明人： Brian Keith Shull
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D491/22
摘要： The present invention relates to compositions and methods for preparing pharmaceutical compositions. In some embodiments, the invention includes compounds and methods of resolving chiral compounds. In some embodiments, the invention includes chiral and crystalline compositions and hydrates. In some embodiments, the invention contemplates compositions comprising camptothecin derivatives and synthetic intermediates thereof. In some embodiments, the invention includes methods of protecting, inserting, modifying, separating isomers, and removing chemical groups.
摘要翻译： 本发明涉及制备药物组合物的组合物和方法。 在一些实施方案中，本发明包括拆分手性化合物的化合物和方法。 在一些实施方案中，本发明包括手性和结晶组合物和水合物。 在一些实施方案中，本发明涉及包含喜树碱衍生物及其合成中间体的组合物。 在一些实施方案中，本发明包括保护，插入，修饰，分离异构体和除去化学基团的方法。
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