公开(公告)号：US20050020193A1

公开(公告)日：2005-01-27

申请号：US10626310

申请日：2003-07-24

申请人： Roger Allaire ,  James Brown ,  Clive Gierbolini ,  Robert Schaeffler

发明人： Roger Allaire ,  James Brown ,  Clive Gierbolini ,  Robert Schaeffler

IPC分类号： B24B9/10 ,  B24B21/00 ,  B24B1/00 ,  B24B7/19

CPC分类号： B24B9/10 ,  B24B21/00

摘要： A rotating belt (10) is used to finish the edges (23) of glass sheets (11), such as, the thin sheets (e.g., 0.7 mm) used as substrates for liquid crystal displays (LCDs). The edge (23) of the sheet (11) engages the working zone (15) of the belt (10) along a line segment (17) whose included angle with the direction of motion (19) of the belt (10) is less than 10°. The working zone (15) is brought into contact with the edge (23) by a pressure sensitive platen (13) which can accommodate errors in the positioning of the sheet (11) at the finishing station (12).

摘要翻译： 旋转带（10）用于完成玻璃板（11）的边缘（23），例如用作液晶显示器（LCD）的基板的薄片（例如，0.7mm）。 片材（11）的边缘（23）沿着与带（10）的运动方向（19）的夹角较小的线段（17）接合带（10）的工作区域（15） 超过10°。 工作区（15）通过压敏压板（13）与边缘（23）接触，该压敏压板可以适应在精加工站（12）处片材（11）的定位误差。

公开(公告)号：US20060258270A1

公开(公告)日：2006-11-16

申请号：US11483827

申请日：2006-07-10

申请人： James Brown ,  Clive Gierbolini ,  Toshihiko Ono ,  Babak Raj ,  Robert Schaeffler

发明人： James Brown ,  Clive Gierbolini ,  Toshihiko Ono ,  Babak Raj ,  Robert Schaeffler

IPC分类号： B24B1/00 ,  B24B55/06 ,  B24B55/04

CPC分类号： B24B55/04 ,  B24B9/10

摘要： An apparatus and method are described herein which help prevent particles and other contaminants that are generated when an edge of a glass sheet is processed from contaminating or damaging the glass sheet. The apparatus includes an encapsulation device and a processing device. The encapsulation device is capable of supporting two surfaces of a glass sheet. And, the processing device is capable of processing (e.g., cutting, scribing, grinding or polishing) the edge that is adjacent to the supported two surfaces of the glass sheet which are located on a first side of the encapsulation device. The encapsulation device is also capable of substantially preventing particles and other contaminants that are generated when the processing device processes the edge of the glass sheet from reaching the two surfaces of the glass sheet which are located on a second side of the encapsulation device.

摘要翻译： 本文描述了一种装置和方法，其有助于防止当玻璃板的边缘被处理时产生的颗粒和其它污染物污染或损坏玻璃板。 该装置包括封装装置和处理装置。 封装装置能够支撑玻璃板的两个表面。 并且，处理装置能够处理（例如，切割，划线，研磨或抛光）与位于封装装置的第一侧上的玻璃板的被支撑的两个表面相邻的边缘。 封装装置还能够基本上防止当处理装置处理玻璃板的边缘到达位于封装装置的第二侧的玻璃板的两个表面时产生的颗粒和其它污染物。

公开(公告)号：US20050090189A1

公开(公告)日：2005-04-28

申请号：US10694693

申请日：2003-10-27

申请人： James Brown ,  Clive Gierbolini ,  Toshihiko Ono ,  Babak Raj ,  Robert Schaeffler

发明人： James Brown ,  Clive Gierbolini ,  Toshihiko Ono ,  Babak Raj ,  Robert Schaeffler

IPC分类号： B24B9/10 ,  B24B55/04 ,  B24B1/00

CPC分类号： B24B55/04 ,  B24B9/10

摘要： An apparatus and method are described herein which help prevent particles and other contaminants that are generated when an edge of a glass sheet is processed from contaminating or damaging the glass sheet. The apparatus includes an encapsulation device and a processing device. The encapsulation device is capable of supporting two surfaces of a glass sheet. And, the processing device is capable of processing (e.g., cutting, scribing, grinding or polishing) the edge that is adjacent to the supported two surfaces of the glass sheet which are located on a first side of the encapsulation device. The encapsulation device is also capable of substantially preventing particles and other contaminants that are generated when the processing device processes the edge of the glass sheet from reaching the two surfaces of the glass sheet which are located on a second side of the encapsulation device.

摘要翻译： 本文描述了一种装置和方法，其有助于防止当玻璃板的边缘被处理时产生的颗粒和其它污染物污染或损坏玻璃板。 该装置包括封装装置和处理装置。 封装装置能够支撑玻璃板的两个表面。 并且，处理装置能够处理（例如，切割，划线，研磨或抛光）与位于封装装置的第一侧上的玻璃板的被支撑的两个表面相邻的边缘。 封装装置还能够基本上防止当处理装置处理玻璃板的边缘到达位于封装装置的第二侧的玻璃板的两个表面时产生的颗粒和其它污染物。

公开(公告)号：US20060121832A1

公开(公告)日：2006-06-08

申请号：US11333730

申请日：2006-01-17

申请人： Roger Allaire ,  James Brown ,  Toshihiko Ono ,  Babak Raj ,  Masayuki Shinkai

发明人： Roger Allaire ,  James Brown ,  Toshihiko Ono ,  Babak Raj ,  Masayuki Shinkai

IPC分类号： B24B51/00 ,  B24B1/00

CPC分类号： B24B41/068 ,  B24B9/102 ,  B24B41/04 ,  B24B49/16

摘要： The present invention is directed to an apparatus for grinding or polishing at least one edge of a glass substrate. The apparatus includes an air bearing support member configured to pivot about an axis of rotation with zero frictional resistance opposing said pivotal movement. A grinding unit is coupled to the air bearing support member. The grinding unit is configured to apply a predetermined force normal to the at least one edge to remove a predetermined amount of material from the at least one edge. The predetermined force is directly proportional to the predetermined amount of material and less than a normal force resulting in glass substrate breakage.

公开(公告)号：US20050026541A1

公开(公告)日：2005-02-03

申请号：US10629399

申请日：2003-07-29

申请人： Roger Allaire ,  James Brown ,  Toshihiko Ono ,  Babak Raj ,  Masayuki Shinkai

发明人： Roger Allaire ,  James Brown ,  Toshihiko Ono ,  Babak Raj ,  Masayuki Shinkai

IPC分类号： B24B9/10 ,  B24B41/04 ,  B24B41/06 ,  B24B49/16 ,  B24B49/00 ,  B24B1/00 ,  B24B51/00

CPC分类号： B24B41/068 ,  B24B9/102 ,  B24B41/04 ,  B24B49/16

摘要： The present invention is directed to an apparatus for grinding or polishing at least one edge of a glass substrate. The apparatus includes an air bearing support member configured to pivot about an axis of rotation with zero frictional resistance opposing said pivotal movement. A grinding unit is coupled to the air bearing support member. The grinding unit is configured to apply a predetermined force normal to the at least one edge to remove a predetermined amount of material from the at least one edge. The predetermined force is directly proportional to the predetermined amount of material and less than a normal force resulting in glass substrate breakage.

摘要翻译： 本发明涉及一种用于研磨或抛光玻璃基板的至少一个边缘的装置。 该装置包括空气轴承支撑构件，该空气轴承支撑构件构造成围绕具有相对于所述枢转运动的零摩擦阻力的旋转轴线枢转。 研磨单元联接到空气轴承支撑构件。 研磨单元构造成施加垂直于至少一个边缘的预定力以从至少一个边缘去除预定量的材料。 预定的力与预定量的材料成正比，并且小于导致玻璃衬底断裂的法向力。

公开(公告)号：US20140126949A1

公开(公告)日：2014-05-08

申请号：US14068905

申请日：2013-10-31

申请人： Jack W. Kaufman ,  James Brown

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： A61F13/40

CPC分类号： A61M35/006 ,  A45D34/04 ,  A45D2200/1018 ,  A61L2/00 ,  A61L2/18 ,  A61M35/003 ,  A61M2205/273 ,  B43M11/06

摘要： A single-piece, injection molded, hand-held liquid dispensing applicator. The single-piece applicator comprising a source of fluid and a frangible applicator tip attached to the fluid source. When the frangible applicator tip is broken, the fluid flows from the source to an absorbent member attached to the applicator tip to spread the liquid on a surface. The frangible tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region therebetween. The tongue element may comprise ribs for reinforcement. The frangible tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. The dispensing applicator may be used in various medical applications.

摘要翻译： 单件式注射成型的手持液体分配器。 单件式涂布器包括流体源和连接到流体源的易碎施用器尖端。 当易碎的施用器尖端断裂时，流体从源极流到附接到施用器尖端的吸收构件，以将液体扩散在表面上。 易碎尖端可以包括永久地连接到流体源的支撑元件，相对刚性的舌元件以及它们之间的易碎区域。 舌元件可以包括用于加强的肋。 易碎的尖端可以包括半渗透或不可渗透的盖，以控制流体的分散体的速度和方向。 分配施加器可以用于各种医疗应用中。

公开(公告)号：US08573542B2

公开(公告)日：2013-11-05

申请号：US12855793

申请日：2010-08-13

申请人： James Brown

发明人： James Brown

IPC分类号： B64C3/00

CPC分类号： B64C21/04 ,  Y02T50/166

摘要： An aerofoil defining geometric upper and lower surfaces which together form a leading edge region and a trailing edge region, and comprising a blowing device having a slot in the lower geometric surface in the leading edge region for injecting fluid into the airflow over the aerofoil, wherein the slot is located forward of the leading edge stagnation point at the critical angle of incidence of the aerofoil, and wherein the blowing device is adapted to inject the fluid forwardly of the slot and substantially parallel to the lower surface. Also, a method of improving the performance of the aerofoil by injecting fluid into the airflow over the aerofoil from the slot. The upper surface of the aerofoil can be kept clean, giving the potential for laminar flow during cruise without significantly compromising the high lift performance of a blown leading edge at high incidence.

摘要翻译： 机翼限定几何上下表面，它们一起形成前缘区域和后缘区域，并且包括吹风装置，该吹风装置在前缘区域中的下几何表面中具有狭槽，用于将流体喷射到机翼上的气流中，其中 所述槽位于所述翼缘的临界入射角处的所述前缘停滞点的前方，并且其中所述吹风装置适于将所述流体向前注入并基本上平行于所述下表面。 而且，一种通过将流体从狭槽喷射到机翼上的空气中来提高机翼的性能的方法。 机翼的上表面可以保持清洁，在巡航期间具有层流的潜力，而不会显着损害高发射时的吹风前缘的高提升性能。

公开(公告)号：US08511923B2

公开(公告)日：2013-08-20

申请号：US13455620

申请日：2012-04-25

申请人： Jack W. Kaufman ,  James Brown

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： B43K5/14

CPC分类号： A61M35/006 ,  A45D34/042 ,  A61M35/003 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。

公开(公告)号：US20130028651A1

公开(公告)日：2013-01-31

申请号：US13601755

申请日：2012-08-31

申请人： James Brown ,  Janet P. Kaufman

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： B05C17/00

CPC分类号： A61M35/006 ,  A45D34/04 ,  A45D2200/1018 ,  A61L2/00 ,  A61L2/18 ,  A61M35/003 ,  A61M2205/273 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. The applicator may be applicable for a medical purpose. When the frangible applicator tip is broken, the fluid flows from the source to the absorbent member, spread on a surface. The frangible applicator tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region there between. The tongue element may comprise ribs for reinforcing the tongue element. The applicator tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 施用器可以适用于医疗目的。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，扩散在表面上。 易碎的施用器尖端可以包括永久地连接到流体源的支撑元件，相对刚性的舌元件以及其间的易碎区域。 舌元件可以包括用于加强舌元件的肋。 施用器尖端可以包括半渗透性或不可渗透的覆盖物，以控制流体的分散体的速度和方向。

公开(公告)号：US20130018064A1

公开(公告)日：2013-01-17

申请号：US13511360

申请日：2010-11-19

申请人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

发明人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

IPC分类号： A61K31/506 ,  A61P25/28 ,  A61K31/4709 ,  C07D401/08 ,  C07D401/06

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。