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1.发明授权Small molecule composite surfaces as inhibitors of protein-protein interactions 有权小分子复合物表面作为蛋白质 - 蛋白质相互作用的抑制剂公开(公告)号：US09260484B2
公开(公告)日：2016-02-16
申请号：US14126343
申请日：2012-06-15
申请人： Roger Briesewitz , Dehua Pei , Xianghong Wu
发明人： Roger Briesewitz , Dehua Pei , Xianghong Wu
摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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2.发明申请SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS 有权作为蛋白质 - 蛋白质相互作用的抑制剂的小分子复合表面公开(公告)号：US20140200186A1
公开(公告)日：2014-07-17
申请号：US14126343
申请日：2012-06-15
申请人： Roger Briesewitz , Dehua Pei , Xianghong Wu
发明人： Roger Briesewitz , Dehua Pei , Xianghong Wu
IPC分类号： C07K11/02
摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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3.发明申请SMALL MOLECULE COMPOSITE SURFACES AS INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS 审中-公开作为蛋白质 - 蛋白质相互作用的抑制剂的小分子复合表面公开(公告)号：US20160333054A1
公开(公告)日：2016-11-17
申请号：US14997302
申请日：2016-08-01
申请人： Roger Briesewitz , Dehua Pei , Xianghong Wu
发明人： Roger Briesewitz , Dehua Pei , Xianghong Wu
IPC分类号： C07K11/02
摘要： A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一种抑制靶蛋白和结合蛋白之间的结合事件的方法，包括向细胞体外施用有效量的非天然存在的双功能抑制剂分子，包括（a）蛋白质结合部分，和（b）效应子区域 其中所述蛋白质结合部分与阻断蛋白结合，并且其中所述效应区结合所述靶蛋白以便结合所述靶蛋白和所述阻断蛋白并阻止所述结合蛋白进入所述靶蛋白。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US08445678B2
公开(公告)日：2013-05-21
申请号：US13270782
申请日：2011-10-11
申请人： Anne E. V. Gorden , Xianghong Wu
发明人： Anne E. V. Gorden , Xianghong Wu
IPC分类号： C07D241/36 , G01N33/00
CPC分类号： C07D241/44 , C07D241/52
摘要： Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.
摘要翻译： 公开了2-喹喔啉醇salen化合物，特别是2-喹喔啉醇salen席夫碱配体。 所公开的2-喹喔啉醇盐化合物可用作与阳离子形成络合物的配体，此外，所形成的络合物可用作氧化反应的催化剂。 所公开的2-喹喔啉醇salen化合物也可以与固体支持物缀合并用于选择性固相萃取或阳离子检测的方法中。
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公开(公告)号：US20120028362A1
公开(公告)日：2012-02-02
申请号：US13270782
申请日：2011-10-11
申请人： Anne E. V. Gorden , Xianghong Wu
发明人： Anne E. V. Gorden , Xianghong Wu
IPC分类号： G01N33/20 , C07D403/06 , C07F1/08 , C08F110/02 , C07F15/04 , C07F5/00 , C07F13/00 , C08F112/08 , C07D241/44 , C07F15/06
CPC分类号： C07D241/44 , C07D241/52
摘要： Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.
摘要翻译： 公开了2-喹喔啉醇salen化合物，特别是2-喹喔啉醇salen席夫碱配体。 所公开的2-喹喔啉醇盐化合物可用作与阳离子形成络合物的配体，此外，所形成的络合物可用作氧化反应的催化剂。 所公开的2-喹喔啉醇salen化合物也可以与固体支持物缀合并用于选择性固相萃取或阳离子检测的方法中。
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公开(公告)号：US20090286968A1
公开(公告)日：2009-11-19
申请号：US12429933
申请日：2009-04-24
申请人： Anne E. V. Gorden , Xianghong Wu
发明人： Anne E. V. Gorden , Xianghong Wu
IPC分类号： C07D241/52 , C08F126/02 , C08F114/02 , C08F120/00 , C07F5/00 , C07F15/04 , C07F15/06 , C07F1/08 , C07F13/00 , C07C29/04 , C07D213/12 , C07C209/00 , G01J1/42
CPC分类号： C07D241/44 , C07D241/52
摘要： Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.
摘要翻译： 公开了2-喹喔啉醇salen化合物，特别是2-喹喔啉醇salen席夫碱配体。 所公开的2-喹喔啉醇盐化合物可用作与阳离子形成络合物的配体，此外，所形成的络合物可用作氧化反应的催化剂。 所公开的2-喹喔啉醇salen化合物也可以与固体支持物缀合并用于选择性固相萃取或阳离子检测的方法中。
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