公开(公告)号：US20050288316A1

公开(公告)日：2005-12-29

申请号：US10995067

申请日：2004-11-22

申请人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

发明人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

IPC分类号： A61K20060101 ,  A61K31/407 ,  A61K31/4747 ,  C07D471/20 ,  C07D491/14 ,  C07D491/20

CPC分类号： C07D471/20 ,  C07D491/20

摘要： The present invention relates to compounds of Formula (I): wherein R3-R8, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.

摘要翻译： 本发明涉及式（I）的化合物：其中R 3，R 8，X和Y如本文所述，制备化合物的方法，药物组合物 包括化合物，以及化合物和组合物在预防或治疗GHSR受体相关病症中的用途。 这种障碍的例子是肥胖症和相关疾病，例如II型糖尿病，血脂异常和代谢综合征Prader-Willi综合征，心血管疾病如动脉粥样硬化性血管疾病，心绞痛，心肌梗塞和中风，肢端肥大症和癌症，特别是乳腺，肺 ，前列腺，甲状腺和内分泌胰腺癌。