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公开(公告)号：US06844366B2
公开(公告)日：2005-01-18
申请号：US10267292
申请日：2002-10-09
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61P43/00 , C07C311/27 , C07D209/08 , C07D209/12 , C07D235/06 , C07D317/58 , A61K31/165 , C07C259/04
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及某些磺酰胺衍生物，其是前胶原C-蛋白酶的抑制剂，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06787559B2
公开(公告)日：2004-09-07
申请号：US10267727
申请日：2002-10-09
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
摘要翻译： 本发明涉及某些作为前胶原C-蛋白酶抑制剂的磺酰胺衍生物，含有它们的药物组合物，其使用方法和制备这些化合物的方法。
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公开(公告)号：US06492394B1
公开(公告)日：2002-12-10
申请号：US09469660
申请日：1999-12-22
申请人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
发明人： Roland Joseph Billledeau , Chris Allen Broka , Jeffrey Allen Campbell , Jian Jeffrey Chen , Sharon Marie Dankwardt , Nancy Delaet , Leslie Ann Robinson , Keith Adrian Murray Walker
IPC分类号： A61K31445
CPC分类号： C07D235/06 , C07C311/27 , C07D209/08 , C07D209/12 , C07D317/58
摘要： A compound of the Formula (I): wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.
摘要翻译： 式（I）的化合物：其中Z，R1，R和Ar2如说明书中所定义。 本发明还涉及作为原胶原C-蛋白酶抑制剂的式（I）的磺酰胺化合物，含有它们的药物组合物，其用途及其制备方法。
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公开(公告)号：US07396936B1
公开(公告)日：2008-07-08
申请号：US11270046
申请日：2005-11-09
申请人： Kent Pryor , Jan Urban , Lubomir Sebo , Stephen Miller , Nancy Delaet
发明人： Kent Pryor , Jan Urban , Lubomir Sebo , Stephen Miller , Nancy Delaet
IPC分类号： C07D405/02 , C07D401/02 , A61K31/44 , A61K31/465
CPC分类号： C07D405/12 , C07D213/82
摘要： In various aspects, the present invention relates to non-peptidic compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of some such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone diseases and metabolic diseases.
摘要翻译： 在各个方面，本发明涉及调节降钙素和胰岛淀粉样多肽受体活性的非肽化合物; 制备一些这类化合物的方法; 以及包含这些化合物的药物组合物。 本发明的化合物可用作降钙素和/或胰岛淀粉样多肽激动剂和治疗骨疾病和代谢疾病。
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公开(公告)号：US20070088163A1
公开(公告)日：2007-04-19
申请号：US10571031
申请日：2004-09-10
申请人： Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
发明人： Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
IPC分类号： C07D471/02 , C07D215/16
CPC分类号： C07D471/04 , C07D405/12
摘要： In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease such as osteoporosis, Paget's disease, hypercalcemia, and in the treatment of metabolic diseases, such as insulin-requiring states.
摘要翻译： 在各个方面，本发明涉及调节降钙素和胰岛淀粉样多肽受体活性的新化合物; 制备这些化合物的方法; 以及包含这些化合物的药物组合物。 本发明的化合物可用作降钙素和/或胰岛淀粉样多肽激动剂和治疗骨疾病如骨质疏松症，佩吉特氏病，高钙血症，以及治疗代谢疾病如胰岛素需求状态。
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公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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7.发明授权Cyclic peptide inhibitors of .beta..sub.1 and .beta..sub.2 integrin-mediated adhesion 失效β1和β2整联蛋白介导的粘附的环肽抑制剂
公开(公告)号：US5821329A
公开(公告)日：1998-10-13
申请号：US738838
申请日：1996-10-28
摘要： The present invention describes cyclic peptide compounds which modulate integrin mediated adhesion. These compounds can inhibit both .beta..sub.1 and .beta..sub.2 mediated adhesion. The invention further relates to therapeutic uses for these compounds in the treatment of adhesion related pathologies.
摘要翻译： 本发明描述了调节整联蛋白介导的粘附的环肽化合物。 这些化合物可以抑制β1和β2介导的粘附。 本发明还涉及这些化合物在治疗粘连相关病变中的治疗用途。
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