公开(公告)号：US20130345240A1

公开(公告)日：2013-12-26

申请号：US13969401

申请日：2013-08-16

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D213/74 ,  C07D417/04 ,  C07D471/04 ,  C07D413/04 ,  C07D409/04 ,  C07D401/04 ,  C07D413/14 ,  C07D409/14 ,  C07D405/14 ,  C07D405/04 ,  C07D417/14

CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US08546403B2

公开(公告)日：2013-10-01

申请号：US13085324

申请日：2011-04-12

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D405/10 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D417/10 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04 ,  A61K31/497 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/437 ,  A61P29/00 ,  A61P13/12 ,  A61P11/00 ,  A61P1/00 ,  A61P19/02 ,  A61P19/10 ,  A61P37/06 ,  A61P25/00 ,  A61P17/06

CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20130245025A1

公开(公告)日：2013-09-19

申请号：US13733795

申请日：2013-01-03

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D333/38 ,  C07D471/04 ,  C07D417/12 ,  C07D409/12 ,  C07D495/04 ,  C07D413/12 ,  C07D491/048

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20130143927A1

公开(公告)日：2013-06-06

申请号：US13492721

申请日：2012-06-08

申请人： Jeffrey P. WHITTEN ,  Jonathan GREY ,  Jianguo CAO ,  Zhijun WANG ,  Evan ROGERS

发明人： Jeffrey P. WHITTEN ,  Jonathan GREY ,  Jianguo CAO ,  Zhijun WANG ,  Evan ROGERS

IPC分类号： A61K31/4741 ,  C07D277/42 ,  C07D417/06 ,  C07D277/54 ,  C07D413/14 ,  C07D413/06 ,  C07D417/12 ,  C07D417/10 ,  C07D417/14 ,  C07D263/48 ,  C07D413/12 ,  A61K31/4439 ,  C07D417/04 ,  C07D498/04 ,  A61K31/427

CPC分类号： C07D277/42 ,  C07D263/48 ,  C07D277/54 ,  C07D409/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20120071516A1

公开(公告)日：2012-03-22

申请号：US13240548

申请日：2011-09-22

申请人： Jianguo Cao ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Zhijun Wang ,  Evan Rogers ,  Jonathan Grey

发明人： Jianguo Cao ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Zhijun Wang ,  Evan Rogers ,  Jonathan Grey

IPC分类号： A61K31/4439 ,  C07D401/14 ,  C07D417/14 ,  C07D277/64 ,  A61P3/14 ,  C07D293/06 ,  A61K31/4155 ,  A61K31/428 ,  A61K31/343 ,  A61K31/41 ,  C07D231/12 ,  C07D307/36

CPC分类号： C07D421/04 ,  C07D293/06 ,  C07D421/12 ,  C07D421/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20110263612A1

公开(公告)日：2011-10-27

申请号：US13085324

申请日：2011-04-12

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/497 ,  A61K31/44 ,  C07D405/10 ,  A61K31/4433 ,  C07D417/10 ,  A61K31/4439 ,  C07D401/10 ,  C07D413/10 ,  C07D413/14 ,  A61K31/444 ,  C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P13/12 ,  A61P11/00 ,  A61P1/00 ,  A61P19/02 ,  A61P19/10 ,  A61P37/06 ,  A61P25/00 ,  A61P17/06 ,  C07D213/75

CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D493/10 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US20110166159A1

公开(公告)日：2011-07-07

申请号：US13050356

申请日：2011-03-17

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/497 ,  C07D409/04 ,  A61K31/381 ,  C07D401/04 ,  A61K31/4436 ,  C07D403/04 ,  A61K31/506 ,  A61K31/405 ,  A61K31/4184 ,  C07D417/14 ,  A61K31/428 ,  C07D401/14 ,  A61K31/4709 ,  A61K31/4155 ,  A61K31/4535 ,  A61P1/00 ,  A61P19/02 ,  A61P3/10 ,  A61P25/28 ,  A61P17/06 ,  A61P37/06 ,  A61P7/06

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US07906553B2

公开(公告)日：2011-03-15

申请号：US12548189

申请日：2009-08-26

申请人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Gonul Velicelebi ,  Kenneth A. Stauderman ,  Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： A61K31/38

CPC分类号： C07D409/04 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： Described herein are compounds of Formula (I) having the structure: where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

摘要翻译： 本文描述了具有以下结构的式（I）的化合物：其中A，J，R 1，R 4，Z和X在本文中描述; 和含有这种化合物的药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20210060576A1

公开(公告)日：2021-03-04

申请号：US16655249

申请日：2019-10-17

申请人： ZHIJUN WANG

发明人： ZHIJUN WANG ,  JINMEI ZHANG

IPC分类号： B03C1/02 ,  B01F7/00 ,  B02C18/14 ,  C02F1/52

摘要： The present disclosure relates to a field of sewage treatment, specifically an efficient sewage treatment device for household garbage, which includes a machine body 1, a stirring cavity, a crushing cavity, a flocculation cavity; a filter cavity, and a water tank. The stirring cavity, the crushing cavity, the flocculation cavity, and the filter cavity are disposed inside the machine body. The stirring cavity is configured to remove iron from garbage, the crushing cavity is configured to crush the garbage, the flocculation cavity is configured to perform solid-liquid separation on the garbage, and the filter cavity is configured to filter sewage.

公开(公告)号：US20130203818A1

公开(公告)日：2013-08-08

申请号：US13643537

申请日：2011-04-27

申请人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

发明人： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC分类号： C07D231/12 ,  C07D417/12 ,  C07D405/12 ,  C07D413/12 ,  C07D409/04 ,  C07D231/14 ,  C07D417/14 ,  C07D231/16 ,  C07D413/04 ,  C07D413/14 ,  C07D405/04 ,  C07D401/12 ,  C07D409/14

CPC分类号： C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.