-
公开(公告)号：US20070088163A1
公开(公告)日：2007-04-19
申请号：US10571031
申请日：2004-09-10
申请人： Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
发明人： Kent Pryor , Eddine Saiah , Jeffrey Kahl , Nancy Delaet , Edward Roberts , Jan Urban , Lubomir Sebo , Christopher Lum , Hiroshi Nakanishi
IPC分类号： C07D471/02 , C07D215/16
CPC分类号： C07D471/04 , C07D405/12
摘要： In various aspects, the present invention relates to novel compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of such compounds; and to pharmaceutical compositions including such compounds. Compounds of the invention are useful as calcitonin and/or amylin agonists and in the treatment of bone disease such as osteoporosis, Paget's disease, hypercalcemia, and in the treatment of metabolic diseases, such as insulin-requiring states.
摘要翻译： 在各个方面，本发明涉及调节降钙素和胰岛淀粉样多肽受体活性的新化合物; 制备这些化合物的方法; 以及包含这些化合物的药物组合物。 本发明的化合物可用作降钙素和/或胰岛淀粉样多肽激动剂和治疗骨疾病如骨质疏松症，佩吉特氏病，高钙血症，以及治疗代谢疾病如胰岛素需求状态。
-
公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
-
公开(公告)号：US07919617B2
公开(公告)日：2011-04-05
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： C07D265/30 , A61K31/5377
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
-
公开(公告)号：US07897599B2
公开(公告)日：2011-03-01
申请号：US12637714
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： A61K31/535 , C07D265/30
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
-
公开(公告)号：US07749999B2
公开(公告)日：2010-07-06
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
IPC分类号： A61K31/535 , C07D265/30
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
-
公开(公告)号：US20100093735A1
公开(公告)日：2010-04-15
申请号：US12637714
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： A61K31/535 , C07D295/155
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
-
公开(公告)号：US20100273797A1
公开(公告)日：2010-10-28
申请号：US12829701
申请日：2010-07-02
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。
-
公开(公告)号：US20100093734A1
公开(公告)日：2010-04-15
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5375 , C07D295/14
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
-
9.发明申请公开(公告)号：US20080199480A1
公开(公告)日：2008-08-21
申请号：US11572420
申请日：2004-07-22
申请人： Maria L. Langdown , Matthew R. Nelson , Rikard H. Reneland , Stefan M. Kammerer , Andreas Braun , Mikhail F. Denissenko , Josephine M. Atienza , Eddine Saiah , James W. Zapf
发明人： Maria L. Langdown , Matthew R. Nelson , Rikard H. Reneland , Stefan M. Kammerer , Andreas Braun , Mikhail F. Denissenko , Josephine M. Atienza , Eddine Saiah , James W. Zapf
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Provided herein are methods for identifying a risk of type II diabetes in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating type II diabetes, and therapeutic and preventative methods applicable to type II diabetes. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.
摘要翻译： 本文提供用于鉴定受试者的II型糖尿病的风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于治疗II型糖尿病的候选治疗剂的方法，以及适用于II型糖尿病的治疗和预防方法。 这些实施方案基于对人类基因组内核苷酸序列的多态变异的分析。
-
公开(公告)号：US20080004325A1
公开(公告)日：2008-01-03
申请号：US11824007
申请日：2007-06-29
申请人： Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Eva Binnun , David V. Erbe , Eddine Saiah
发明人： Jinbo Lee , Zhao-Kui Wan , Douglas P. Wilson , Eva Binnun , David V. Erbe , Eddine Saiah
IPC分类号： A61K31/433 , C07D417/04
CPC分类号： C07D417/04
摘要： This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1b (PTP1b).
摘要翻译： 本发明涉及调节（例如抑制）蛋白酪氨酸磷酸酶1b（PTP1b）。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.066 秒)
