公开(公告)号：US4724204A

公开(公告)日：1988-02-09

申请号：US523400

申请日：1983-08-15

申请人： Roland W. Steinbach ,  Asok K. Roy ,  Peter Krauss

发明人： Roland W. Steinbach ,  Asok K. Roy ,  Peter Krauss

IPC分类号： G01N33/50 ,  A61B5/00 ,  A61K49/00 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/48 ,  A61F13/16

CPC分类号： C12Q1/26 ,  Y10S604/904

摘要： A diagnostic device for the detection of an increased concentration of dehydrogenases and/or oxidases in the fluids of humans, animals or plants, which consists of a carrier which bonds a redox dyestuff, and a substance mixture, adjusted to a pH value in the acid range, of the substrate corresponding to the particular dehydrogenase, a hydrogen donor compound and at least one redox dyestuff is described. The device has the peculiarity that the carrier contains polar groups and the substance mixture for detecting exclusively pathologically increased concentrations of the particular dehydrogenase and/or oxidase is adjusted to a pH value of below 5.0. The device is suitable for diagnosing malignant growths in very different organs, for example in the female genital area.

摘要翻译： 用于检测人，动物或植物的流体中脱氢酶和/或氧化酶浓度增加的诊断装置，其由与氧化还原染料结合的载体和调节至酸中pH值的物质混合物组成 描述对应于特定脱氢酶的底物的范围，氢供体化合物和至少一种氧化还原染料。 该装置具有载体包含极性基团的特性，并且用于检测特异性脱氢酶和/或氧化酶的病理增加浓度的物质混合物被调节至低于5.0的pH值。 该装置适用于诊断非常不同器官的恶性生长，例如在女性生殖器区域。

公开(公告)号：US4666833A

公开(公告)日：1987-05-19

申请号：US523394

申请日：1983-08-15

申请人： Asok K. Roy ,  Roland W. Steinbach

发明人： Asok K. Roy ,  Roland W. Steinbach

IPC分类号： A61B8/00 ,  A61B5/00 ,  A61K49/00 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/48 ,  G01N33/52 ,  A61F13/16 ,  B65D69/00 ,  C12N9/96

CPC分类号： C12Q1/26 ,  Y10S206/829 ,  Y10S435/805 ,  Y10S604/904

摘要： A process for the production of a diagnostic device which is envisaged, in particular, for the detection of a pathologically increased concentration of dehydrogenases in fluids of humans, animals or plants and consists of a carrier and a substance mixture, in which, in each case with exclusion of UV radiation, the substance mixture, which has been adjusted to a pH value in the acid range, is brought into contact, in liquid form, with the carrier and the combination of carrier and substance mixture is subsequently dried and then enclosed in a packaging casing which is opaque to light of higher energy than red light. The process has the peculiarity that the dried combination of carrier and substance mixture in the packaging casing is securely sealed against entry of air and moisture. The device thus produced can be stored for a long time before use, without its ability to function being substantially changed.

摘要翻译： 用于生产诊断装置的方法，其特别是用于检测在人，动物或植物的流体中病态增加的脱氢酶浓度，并由载体和物质混合物组成，其中在每种情况下 在排除紫外线辐射的情况下，已经调节到酸范围内的pH值的物质混合物以液体形式与载体接触，随后将载体和物质混合物的组合干燥，然后封入 对于比红光更高能量的光不透明的包装外壳。 该方法的特征在于，包装壳体中的载体和物质混合物的干燥组合被牢固地密封以防止空气和水分进入。 如此制造的装置可以在使用前长时间储存​​，而不会使其功能基本上改变。