Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
    1.
    发明申请
    Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses 审中-公开
    用于治疗披膜病毒,疱疹病毒和冠状病毒感染的磷脂

    公开(公告)号:US20050187192A1

    公开(公告)日:2005-08-25

    申请号:US10783927

    申请日:2004-02-20

    IPC分类号: A61K31/685

    CPC分类号: A61K31/685

    摘要: Provided are compounds, methods and pharmaceutical compositions for treating a host, especially a human, infected with a togavirus, herpes virus and/or coronavirus, and in particular SARS-CoV, cytomegalovirus or varicella-zoster virus. The method in one embodiment comprises administering to that host an effective amount of an anti-togavirus, anti-herpes virus and/or anti-coronavirus phospholipid or a pharmaceutically acceptable salt or prodrug thereof. The phospholipid compound is, e.g., a 3-alkylamido-2-alkoxypropylphosphocholine compound or salt thereof. The compound may be administered alone or in combination and/or alternation with one or more other anti-viral agents.

    摘要翻译: 提供用于治疗感染披膜病毒,疱疹病毒和/或冠状病毒,特别是SARS-CoV,巨细胞病毒或水痘带状疱疹病毒的宿主,特别是人的化合物,方法和药物组合物。 在一个实施方案中的方法包括向该宿主施用有效量的抗披叶病毒,抗疱疹病毒和/或抗冠状病毒磷脂或其药学上可接受的盐或前药。 磷脂化合物是例如3-烷基酰胺基-2-烷氧基丙基磷酰胆碱化合物或其盐。 化合物可以单独施用或与一种或多种其它抗病毒剂组合和/或替代施用。