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7 条记录 (耗时 0.015 秒)

    Compositions and methods for targeting cancer cells
    1.
    发明申请
    Compositions and methods for targeting cancer cells 有权

    公开(公告)号：US20060264397A1

    公开(公告)日：2006-11-23

    申请号：US11398529

    申请日：2006-04-06

    申请人： Louis Kucera ,  Ronald Fleming ,  Khalid Ishaq ,  Gregory Kucera ,  Susan Morris-Natschke

    发明人： Louis Kucera ,  Ronald Fleming ,  Khalid Ishaq ,  Gregory Kucera ,  Susan Morris-Natschke

    IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04

    CPC分类号： C07H19/06 ,  A61K31/66 ,  A61K31/675 ,  C07F9/10 ,  C07H19/10 ,  C07H19/16 ,  Y02A50/463

    摘要： The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions of the invention include compounds which comprise a phosphocholine moiety covalently conjugated with one or more antiviral agents (e.g. nucleoside analogue, protease inhibitor, etc.) to a lipid backbone. The invention also includes pharmaceutical compositions and kits for use in treatment of a virus infection in mammals. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to treat the infection, to a mammal infected with a virus. Additionally, the invention includes compositions and methods useful for combating a cancer in a mammal and for facilitating delivery of a therapeutic agent to a mammalian cell. The compositions of the invention include compounds which comprise an alkyl lipid or phospholipid moiety covalently conjugated with an anticancer agent (e.g. a nucleoside analogue). The invention also includes pharmaceutical compositions and kits for combating a cancer and for facilitating delivery of a therapeutic agent to a mammalian cell. The methods of the invention comprise administering a compound of the invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the invention, in an amount effective to combat a cancer or to facilitate delivery of a therapeutic agent to a mammalian cell.

    Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
    6.
    发明申请
    Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses 审中-公开
    用于治疗披膜病毒，疱疹病毒和冠状病毒感染的磷脂

    公开(公告)号：US20050187192A1

    公开(公告)日：2005-08-25

    申请号：US10783927

    申请日：2004-02-20

    申请人： Ronald Fleming ,  Jan Hes ,  Yunsheng Huang ,  Russ Read ,  Susan Morris-Natschke ,  Khalid Ishaq ,  Louis Kucera ,  Phillip Furman

    发明人： Ronald Fleming ,  Jan Hes ,  Yunsheng Huang ,  Russ Read ,  Susan Morris-Natschke ,  Khalid Ishaq ,  Louis Kucera ,  Phillip Furman

    IPC分类号： A61K31/685

    CPC分类号： A61K31/685

    摘要： Provided are compounds, methods and pharmaceutical compositions for treating a host, especially a human, infected with a togavirus, herpes virus and/or coronavirus, and in particular SARS-CoV, cytomegalovirus or varicella-zoster virus. The method in one embodiment comprises administering to that host an effective amount of an anti-togavirus, anti-herpes virus and/or anti-coronavirus phospholipid or a pharmaceutically acceptable salt or prodrug thereof. The phospholipid compound is, e.g., a 3-alkylamido-2-alkoxypropylphosphocholine compound or salt thereof. The compound may be administered alone or in combination and/or alternation with one or more other anti-viral agents.

    摘要翻译： 提供用于治疗感染披膜病毒，疱疹病毒和/或冠状病毒，特别是SARS-CoV，巨细胞病毒或水痘带状疱疹病毒的宿主，特别是人的化合物，方法和药物组合物。 在一个实施方案中的方法包括向该宿主施用有效量的抗披叶病毒，抗疱疹病毒和/或抗冠状病毒磷脂或其药学上可接受的盐或前药。 磷脂化合物是例如3-烷基酰胺基-2-烷氧基丙基磷酰胆碱化合物或其盐。 化合物可以单独施用或与一种或多种其它抗病毒剂组合和/或替代施用。