专利检索 ap:("Ronald P. Taylor" OR "Polly J. Ferguson" OR "Edward N. Martin, Jr." OR "William M. Sutherland" OR "Craig J. Reist" OR "Kirsten Greene" OR "Cyd Johnson") AND inv:"Cyd Johnson" 第 1 页

1.

发明授权
Antigen-based heteropolymers and method for treating autoimmune diseases using the same 失效

公开(公告)号：US5879679A

公开(公告)日：1999-03-09

申请号：US460861

申请日：1995-06-05

申请人： Ronald P. Taylor , Polly J. Ferguson , Edward N. Martin, Jr. , William M. Sutherland , Craig J. Reist , Kirsten Greene , Cyd Johnson

发明人： Ronald P. Taylor , Polly J. Ferguson , Edward N. Martin, Jr. , William M. Sutherland , Craig J. Reist , Kirsten Greene , Cyd Johnson

IPC分类号： C12N15/02 , A61K35/18 , A61K39/00 , A61K39/395 , A61K39/44 , A61K47/48 , A61P37/00 , C07K16/28 , C07K16/46 , C07K19/00 , C12P21/08 , C12R1/91 , C07K16/00

CPC分类号： C07K16/2896 , A61K39/0008 , A61K47/48561

摘要： Constructs consisting of antigen-based heteropolymers (AHP's) are provided. The antigen-based heteropolymers comprise at least one monoclonal antibody specific for binding to complement receptor (CR1) site on a human or non-human primate erythrocyte, and the anti-CR1 monoclonal antibody is crosslinked to an antigen specific for a target pathogenic autoantibody. Further provided is a method for treating autoimmune diseases in human or non-human primates using the AHP.