公开(公告)号：US5487890A

公开(公告)日：1996-01-30

申请号：US186136

申请日：1994-01-24

申请人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

发明人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

IPC分类号： A61K35/18 ,  A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42

CPC分类号： A61K47/48561 ,  A61K35/18 ,  A61K47/48684 ,  A61K47/48776 ,  C07K16/28 ,  A61K38/00

摘要： Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.

公开(公告)号：US5470570A

公开(公告)日：1995-11-28

申请号：US161812

申请日：1993-12-06

申请人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

发明人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

IPC分类号： A61K35/18 ,  A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42

CPC分类号： A61K47/48561 ,  A61K35/18 ,  A61K47/48684 ,  A61K47/48776 ,  C07K16/28 ,  A61K38/00

摘要： Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.

摘要翻译： 哺乳动物红细胞用于通过与RBC结合在RBC上对于受体（CR1）特异性的单克隆抗体来安全地和快速地中和和/或清除来自循环系统的抗原或免疫原，该单克隆抗体与RBC化学结合 Mab具体针对从循环系统中清除的抗原。 这些化学交联的单克隆抗体杂聚物可以直接注射到患者的循环系统中。 或者，从患者提取或由合适的供体提供的红细胞与Mab复合物结合并返回到系统。