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公开(公告)号：US20120009173A1
公开(公告)日：2012-01-12
申请号：US13243373
申请日：2011-09-23
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 本发明涉及通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI·RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US08293872B2
公开(公告)日：2012-10-23
申请号：US13243373
申请日：2011-09-23
IPC分类号： C07K1/00
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 本发明涉及通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI·RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US08569457B2
公开(公告)日：2013-10-29
申请号：US13619192
申请日：2012-09-14
IPC分类号： C07K1/00
摘要： Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 公开了通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI·RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US20090311784A1
公开(公告)日：2009-12-17
申请号：US12497038
申请日：2009-07-02
IPC分类号： C12N5/02
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 本发明涉及通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI.RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US20130011904A1
公开(公告)日：2013-01-10
申请号：US13619192
申请日：2012-09-14
IPC分类号： C12N9/22
摘要： Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 公开了通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI·RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US08048425B2
公开(公告)日：2011-11-01
申请号：US12497038
申请日：2009-07-02
IPC分类号： A61K39/385
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 本发明涉及通过分析由RNase1 hRI复合物的三维（3-D）原子结构定义的核糖核酸酶1和人核糖核酸酶抑制剂（hRI）之间的相互作用而鉴定的人核糖核酸酶1（核糖核酸酶1）的细胞毒性变体。 还公开了hRI·RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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公开(公告)号：US07655757B2
公开(公告)日：2010-02-02
申请号：US11454418
申请日：2006-06-16
摘要： This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase 1 hRI complex. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing the RNase 1 variants.
摘要翻译： 本发明涉及通过分析核糖核酸酶1和核糖核酸酶抑制剂（hRI）之间的相互作用鉴定的人核糖核酸酶1（RNase 1）的细胞毒性变体，如RNase 1 hRI复合物的三维（3-D）原子结构所定义 。 还公开了hRI.RNase 1复合物的3-D结构和用于设计RNA酶1变体的方法。
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