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公开(公告)号：US20070066651A1
公开(公告)日：2007-03-22
申请号：US11504584
申请日：2006-08-16
申请人： Rosa Cuberes Altisen , Jordi Frigola Constansa , Ramon Mangues Bafalluy , Isolda Casanova Rigal
发明人： Rosa Cuberes Altisen , Jordi Frigola Constansa , Ramon Mangues Bafalluy , Isolda Casanova Rigal
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/416 , A61K31/4178 , A61K31/4152 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/06
摘要： Compounds of formula (I) wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.
摘要翻译： 式（I）的化合物，其中：X选自三卤代甲基，C 1 -C 6烷基和式（II）的基团，其中：R 3个和R 4个独立地选自氢; 卤素; 羟; 硝基 C 1 -C 6烷基; C 1 -C 6烷基; C 1 -C 6烷氧基; 羧基; C 1 -C 6 - 三卤代烷基; 和氰基; Z选自取代和未取代的芳基; 或其药学上可接受的盐。 化合物是环氧合酶-2活性的抑制剂。 它们可用于治疗环氧合酶介导的病症，包括例如炎症，肿瘤性疾病和血管发生介导的病症。
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2.发明申请Substituted Azetidine compounds, their preparation and use as medicaments 审中-公开取代的氮杂环丁烷化合物，其制备和用作药物公开(公告)号：US20050187208A1
公开(公告)日：2005-08-25
申请号：US10804558
申请日：2004-03-19
IPC分类号： C07D205/04 , C07D409/12 , C07D417/12 , C07D513/04 , C07D491/02 , A61K31/397 , A61K31/416 , A61K31/433 , A61K31/4745
CPC分类号： C07D409/12 , C07D205/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代氮杂环丁烷化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。
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3.发明申请Substituted azetidine compounds, their preparation and use as medicaments 审中-公开取代的氮杂环丁烷化合物，其制备和用作药物公开(公告)号：US20070066587A1
公开(公告)日：2007-03-22
申请号：US11505463
申请日：2006-08-17
IPC分类号： A61K31/397 , A61K31/433 , A61K31/4188 , C07D409/02 , C07D405/02 , C07D417/02
CPC分类号： C07D409/12 , C07D205/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代氮杂环丁烷化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。
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公开(公告)号：US20060189658A1
公开(公告)日：2006-08-24
申请号：US11410943
申请日：2006-04-26
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D231/06 , C07D231/14
摘要： The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
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5.发明授权公开(公告)号：US07524868B2
公开(公告)日：2009-04-28
申请号：US11169155
申请日：2005-06-27
IPC分类号： A61K31/4155 , C07D401/02
CPC分类号： C07D231/06 , C07D231/14
摘要： The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及取代的吡唑啉化合物，其制备方法，包含这些化合物的药物及其用于制备用于治疗人和动物的药物的用途。
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公开(公告)号：US07232812B2
公开(公告)日：2007-06-19
申请号：US10804505
申请日：2004-03-19
IPC分类号： A61K31/397 , C07D205/04
CPC分类号： C07D205/04 , C07D405/06
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
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7.发明申请Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments 审中-公开取代的氮杂环丁烷化合物作为环加氧酶-1环氧合酶-2抑制剂及其作为药物的制备和用途公开(公告)号：US20070093469A1
公开(公告)日：2007-04-26
申请号：US11504720
申请日：2006-08-16
IPC分类号： A61K31/397 , C07D205/02
CPC分类号： C07D205/04 , C07D405/06
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代氮杂环丁烷化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。
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8.发明申请Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity 审中-公开包含具有npy受体亲和力的化合物和具有5-ht6受体亲和力的化合物的活性物质组合公开(公告)号：US20070059364A1
公开(公告)日：2007-03-15
申请号：US10566100
申请日：2004-07-29
申请人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC分类号： A61K31/538 , A61K31/404 , A61K9/22
CPC分类号： A61K31/404 , A61K31/4045 , A61K31/536 , A61K2300/00
摘要： The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT 6受体亲和力的化合物的活性物质组合物，包含所述活性物质组合的药物，以及所述活性物质组合物用于 制造药物。
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9.发明申请Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity 审中-公开包含具有npy受体亲和力的化合物和具有5-ht6受体亲和力的化合物的活性物质组合公开(公告)号：US20070009597A1
公开(公告)日：2007-01-11
申请号：US10566402
申请日：2004-07-29
申请人： Antoni Torrens Jover , Josep Mas Prio , Albert Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Albert Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC分类号： A61K39/395 , A61K31/538 , A61K31/445 , A61K31/405 , A61K9/22
CPC分类号： A61K45/06
摘要： The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity, preferably neuropeptide Y5-receptor affinity, and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物，优选神经肽Y5-受体亲和力的活性物质组合物和至少一种具有5-HT 6受体亲和力的化合物，药物 包括所述活性物质组合，以及所述活性物质组合用于制备药物的用途。
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公开(公告)号：US07056914B2
公开(公告)日：2006-06-06
申请号：US10407343
申请日：2003-04-04
申请人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
发明人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
IPC分类号： C07D405/04 , C07D405/14 , A61K31/536 , A61P3/04
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
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