公开(公告)号：US4849428A

公开(公告)日：1989-07-18

申请号：US123756

申请日：1987-11-23

申请人： Roy L. M. Dobson ,  Maurice E. Loomans ,  Randall S. Matthews ,  Joseph A. Miller

发明人： Roy L. M. Dobson ,  Maurice E. Loomans ,  Randall S. Matthews ,  Joseph A. Miller

IPC分类号： C07D307/87 ,  A61K31/34 ,  A61K31/343 ,  A61P29/00 ,  C07D307/79 ,  C07D307/83 ,  C07D307/88

CPC分类号： C07D307/79 ,  C07D307/83

摘要： The present invention involves compounds having the structure: ##STR1## (a) --A-- is selected from the group consisting of ##STR2## (b) --Y is selected from certain low molecular weight moieties which terminate in specific functional groups: --C.tbd.CH, ##STR3## and aldehydes in the form of their acetals; pharmaceutical compositions comprising such compounds; and methods for treating inflammation by administering such compounds.

公开(公告)号：US5280045A

公开(公告)日：1994-01-18

申请号：US951547

申请日：1992-10-01

申请人： Roy L. M. Dobson ,  Kenneth R. Wehmeyer ,  Steven P. Sirko ,  Benjamin F. Floyd

发明人： Roy L. M. Dobson ,  Kenneth R. Wehmeyer ,  Steven P. Sirko ,  Benjamin F. Floyd

IPC分类号： A61K31/165 ,  A61K31/19 ,  C07C235/78 ,  A61K31/135 ,  C07C59/74 ,  C07C229/00

CPC分类号： A61K31/19 ,  A61K31/165 ,  C07C235/78

摘要： The subject invention involves compositions comprising 4-(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide, or 4-(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl)-4-oxobutanoic acid and pharmaceutically-acceptable salts thereof, and a pharmaceutically-acceptable carrier. The subject invention also involves methods for treating diseases characterized by inflammation and/or pain, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals by administration of a safe and effective amount of this compound to the human or lower animal in need of such treatment.

摘要翻译： 本发明涉及包含4-（3,5-双（1,1-二甲基乙基）-4-羟基苯基）-4-氧代丁酰胺或4-（3,5-双 - （1,1-二甲基乙基）-4 - 羟基苯基）-4-氧代丁酸及其药学上可接受的盐，和药学上可接受的载体。 本发明还涉及通过向需要这样的人或低级动物施用安全有效量的该化合物来治疗在人类或低等动物中治疗特征为炎症和/或疼痛（例如类风湿性关节炎和骨关节炎）的疾病的方法 治疗。