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公开(公告)号：US4456600A
公开(公告)日：1984-06-26
申请号：US380328
申请日：1982-05-20
IPC分类号： A61K31/565 , A61K31/568 , C07J1/00 , C07J21/00 , A61K31/56
CPC分类号： C07J21/006 , C07J1/0037 , C07J1/0044 , Y10S514/859 , Y10S514/864 , Y10S514/88
摘要： 17.alpha.-substituted steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl,R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms,X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
摘要翻译： 其中R1是氢原子，酰基，烷基，链烯基，被氧原子间隔的烷基或链烯基，环戊基或四氢吡喃基的α-α取代类固醇，R2是2-6个碳原子的烷基或烯基，X是 氧或其中R 3为氢的酰基，烷基，烯基，被氧原子间隔的烷基或链烯基，（环戊基或四氢吡喃基）的基团H（OR 3）在局部施用时显示出抗雄激素特性，可用于治疗痤疮， 皮脂溢，脱发和多毛症。
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公开(公告)号：US4344941A
公开(公告)日：1982-08-17
申请号：US198383
申请日：1980-10-20
IPC分类号： A61K31/565 , A61K31/568 , C07J1/00 , C07J21/00 , A61K31/56 , C07J7/00
CPC分类号： C07J21/006 , C07J1/0037 , C07J1/0044 , Y10S514/859 , Y10S514/864 , Y10S514/88
摘要： 17.alpha.-substituted steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl,R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms,X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
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公开(公告)号：US4892867A
公开(公告)日：1990-01-09
申请号：US918231
申请日：1986-10-14
IPC分类号： A61K31/565 , A61K31/568 , C07J1/00 , C07J21/00
CPC分类号： C07J21/006 , C07J1/0037 , C07J1/0044 , Y10S514/859 , Y10S514/864 , Y10S514/88
摘要： 17.alpha.-Alkyl steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl,R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms,X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
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公开(公告)号：US4558041A
公开(公告)日：1985-12-10
申请号：US620216
申请日：1984-06-13
IPC分类号： A61K31/565 , A61K31/568 , C07J1/00 , C07J21/00 , A61K31/56
CPC分类号： C07J21/006 , C07J1/0037 , C07J1/0044 , Y10S514/859 , Y10S514/864 , Y10S514/88
摘要： 17.alpha.-substituted steroids of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl,R.sub.2 is alkyl or alkenyl of 2-6 carbon atoms,X is oxygen or the grouping H(OR.sub.3) wherein R.sub.3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.
摘要翻译： 其中R1是氢原子，酰基，烷基，链烯基，被氧原子间隔的烷基或链烯基，环戊基或四氢吡喃基的α-α取代类固醇，R2是2-6个碳原子的烷基或烯基，X是 氧或其中R 3为氢的酰基，烷基，烯基，被氧原子间隔的烷基或链烯基，（环戊基或四氢吡喃基）的基团H（OR 3）在局部施用时显示出抗雄激素特性，可用于治疗痤疮， 皮脂溢，脱发和多毛症。
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