公开(公告)号：US5643726A

公开(公告)日：1997-07-01

申请号：US339152

申请日：1994-11-10

申请人： Rudolph E. Tanzi ,  Dora M. Kovacs

发明人： Rudolph E. Tanzi ,  Dora M. Kovacs

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/47 ,  C12N5/10 ,  C12N15/85 ,  C12Q1/02 ,  C12Q1/68 ,  C12N15/63

CPC分类号： C07K14/4705 ,  C07K14/4711 ,  C12N15/85 ,  A61K38/00 ,  C12N2830/00 ,  C12N2830/30 ,  C12N2830/85

摘要： The application concerns methods for modulating transcription from the amyloid .beta.-protein precursor (APP) promoter. The upstream stimulatory factor (USF) is described as being capable of activating transcription from the APP promoter. Also described are USF binding compounds which are capable of down-regulating expression from the APP promoter. Preferred USF binding compounds are the amyloid precursor-like proteins APLP1 and APLP2. The application further concerns a screening assay for determining which candidate USF binding compounds are capable of causing down-regulation of transcription from the APP promoter.

摘要翻译： 该应用涉及从淀粉样蛋白β-蛋白前体（APP）启动子调节转录的方法。 上游刺激因子（USF）被描述为能够激活来自APP启动子的转录。 还描述了能够下调APP启动子表达的USF结合化合物。 优选的USF结合化合物是淀粉样前体样蛋白APLP1和APLP2。 该应用还涉及用于确定哪些候选的USF结合化合物能够引起来自APP启动子的转录下调的筛选测定。