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公开(公告)号:US20080107658A1
公开(公告)日:2008-05-08
申请号:US11814668
申请日:2006-01-24
申请人: Ruth Franks , Andrew Buchanan , Albert Thom , Fraser Welsh , Philip Bland-Ward , Matthew Sleeman , Carl Matthews , Celia Hart , Jon Hawkinson
发明人: Ruth Franks , Andrew Buchanan , Albert Thom , Fraser Welsh , Philip Bland-Ward , Matthew Sleeman , Carl Matthews , Celia Hart , Jon Hawkinson
CPC分类号: C07K16/22 , A61K39/3955 , A61K2039/505 , C07K14/48 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralise NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.
摘要翻译: 神经生长因子(NGF)的特异性结合成员,特别是抗NGF抗体分子,特别是人抗体分子,特别是中和NGF活性的那些。 诊断或治疗NGF相关疾病(包括疼痛,哮喘,慢性阻塞性肺病,肺纤维化,其他气道炎症疾病,糖尿病性神经病,心律失常,HIV,关节炎,牛皮癣和癌症)的方法。
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公开(公告)号:US20070264255A1
公开(公告)日:2007-11-15
申请号:US11700684
申请日:2007-01-30
申请人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
发明人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
IPC分类号: A61K39/395 , C07H21/04 , C07K16/18 , C12N5/06 , C12P1/00
CPC分类号: C07K16/22 , A61K2039/505 , A61P13/12 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及抗体分子,特别是结合转化生长因子β(TGFβ)的抗体分子及其用途。 更具体地,本发明涉及结合并优选中和TGFbeta1,TGFbeta2和TGFbeta3,所谓的“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US20070134246A1
公开(公告)日:2007-06-14
申请号:US11700711
申请日:2007-01-30
申请人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
发明人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
IPC分类号: A61K39/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , A61P13/12 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及抗体分子,特别是结合转化生长因子β(TGFβ)的抗体分子及其用途。 更具体地,本发明涉及结合并优选中和TGFbeta1,TGFbeta2和TGFbeta3,所谓的“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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公开(公告)号:US20060251658A1
公开(公告)日:2006-11-09
申请号:US11350906
申请日:2006-02-08
申请人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
发明人: Steven Ledbetter , Celia Hart , Robert Holgate , Lutz Jermutus , Catriona Buchanan , Alexander Duncan , Donna Finch
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C07K16/22 , C12N5/06
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
摘要翻译: 本发明涉及抗体分子,特别是结合转化生长因子β(TGFβ)的抗体分子及其用途。 更具体地,本发明涉及结合并优选中和TGFbeta1,TGFbeta2和TGFbeta3,所谓的“泛特异性”抗体分子的抗体分子,以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子,无论是全抗体(例如IgG,如IgG1或IgG4)还是抗体片段(例如scFv,Fab,dAb)。
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