公开(公告)号：US20080107658A1

公开(公告)日：2008-05-08

申请号：US11814668

申请日：2006-01-24

Applicant: Ruth Franks ,  Andrew Buchanan ,  Albert Thom ,  Fraser Welsh ,  Philip Bland-Ward ,  Matthew Sleeman ,  Carl Matthews ,  Celia Hart ,  Jon Hawkinson

Inventor： Ruth Franks ,  Andrew Buchanan ,  Albert Thom ,  Fraser Welsh ,  Philip Bland-Ward ,  Matthew Sleeman ,  Carl Matthews ,  Celia Hart ,  Jon Hawkinson

IPC: C07K16/22 ,  A61K39/395 ,  C12N1/00 ,  C12P21/00 ,  G01N33/00 ,  C40B30/04 ,  C12N15/13

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/48 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralise NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.

Abstract translation: 神经生长因子（NGF）的特异性结合成员，特别是抗NGF抗体分子，特别是人抗体分子，特别是中和NGF活性的那些。 诊断或治疗NGF相关疾病（包括疼痛，哮喘，慢性阻塞性肺病，肺纤维化，其他气道炎症疾病，糖尿病性神经病，心律失常，HIV，关节炎，牛皮癣和癌症）的方法。

公开(公告)号：US20060293332A1

公开(公告)日：2006-12-28

申请号：US11429656

申请日：2006-05-05

Applicant: Francine Grant ,  Sarah Bartulis ,  Louis Brogley ,  Michael Dappen ,  Ramesh Kasar ,  Mohammed Khan ,  Martin Neitzel ,  Michael Pleiss ,  Eugene Thorsett ,  John Tucker ,  Michael Ye ,  Jon Hawkinson

Inventor： Francine Grant ,  Sarah Bartulis ,  Louis Brogley ,  Michael Dappen ,  Ramesh Kasar ,  Mohammed Khan ,  Martin Neitzel ,  Michael Pleiss ,  Eugene Thorsett ,  John Tucker ,  Michael Ye ,  Jon Hawkinson

IPC: A61K31/498 ,  C07D241/36

CPC classification number: C07D401/14 ,  C07D241/44 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.