公开(公告)号：US20070049579A1

公开(公告)日：2007-03-01

申请号：US11366454

申请日：2006-03-03

申请人： Ryozo Nagai ,  Ichiro Manabe ,  Takayuki Shindo ,  Hiroshi Iwata ,  Koichi Shudo ,  Hiroyuki Kagechika

发明人： Ryozo Nagai ,  Ichiro Manabe ,  Takayuki Shindo ,  Hiroshi Iwata ,  Koichi Shudo ,  Hiroyuki Kagechika

IPC分类号： A61K31/551

CPC分类号： A61K31/551

摘要： A medicament having a neovascularization promoting action, which comprises a retinoid antagonist such as 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid as an active ingredient and is useful for prophylactic and/or therapeutic treatment of ischemic diseases and wounds.

摘要翻译： 具有新血管形成促进作用的药物，其包含类视黄醇拮抗剂，例如4-（5H-7,8,9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2,3- b] [1,4]二氮杂萘-13-基）苯甲酸作为活性成分，可用于预防和/或治疗缺血性疾病和伤口。

公开(公告)号：US20090118264A1

公开(公告)日：2009-05-07

申请号：US12318248

申请日：2008-12-23

申请人： Ryozo Nagai ,  Ichiro Manabe ,  Takayuki Shindo ,  Hiroshi Iwata ,  Koichi Shudo ,  Hiroyuki Kagechika

发明人： Ryozo Nagai ,  Ichiro Manabe ,  Takayuki Shindo ,  Hiroshi Iwata ,  Koichi Shudo ,  Hiroyuki Kagechika

IPC分类号： A61K31/551 ,  A61K31/4164 ,  A61K31/39 ,  A61K31/4439 ,  A61P9/10

CPC分类号： A61K31/551

摘要： Methods of use of medicaments having neovascularization promoting action, which medicaments comprise a retinoid antagonist such as 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1-,4]diazepin-13-yl)benzoic acid as an active ingredient.

摘要翻译： 使用具有新血管形成促进作用的药物的方法，该药物包含类视黄醇拮抗剂如4-（5H-7,8,9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2 ，3-b] [1-，4]二氮杂-13-基）苯甲酸作为活性成分。

公开(公告)号：US20050234130A1

公开(公告)日：2005-10-20

申请号：US10511274

申请日：2003-04-22

申请人： Ryozo Nagai ,  Takayuki Shindo ,  Ichiro Manabe ,  Koichi Shudo ,  Hiroyuki Kagechika

发明人： Ryozo Nagai ,  Takayuki Shindo ,  Ichiro Manabe ,  Koichi Shudo ,  Hiroyuki Kagechika

IPC分类号： A61K31/27 ,  A61K31/695 ,  A61L31/16 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P43/00 ,  A61K31/195 ,  A61K31/203

CPC分类号： A61K31/27 ,  A61K31/695 ,  A61L31/16

摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[(3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.

摘要翻译： 用于使用血管内支架的经皮腔内冠状动脉成形术之后的血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分 类维生素如4- [5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或其盐或4 - [[[（3,3- （三甲基甲硅烷基）苯基]羰基]氨基]苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。

公开(公告)号：US20090253796A1

公开(公告)日：2009-10-08

申请号：US12412678

申请日：2009-03-27

申请人： Ryozo NAGAI ,  Takayuki Shindo ,  Ichiro Manabe ,  Koichi Shudo ,  Hiroyuki Kagechika

发明人： Ryozo NAGAI ,  Takayuki Shindo ,  Ichiro Manabe ,  Koichi Shudo ,  Hiroyuki Kagechika

IPC分类号： A61K31/196 ,  A61P9/10

CPC分类号： A61K31/27 ,  A61K31/695 ,  A61L31/16

摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.

摘要翻译： 用于使用血管内支架的经皮腔内冠状动脉成形术之后的血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分 类维生素如4- [5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或其盐或4 - [[[3,5- - 双（三甲基甲硅烷基）苯基]羰基]氨基]苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。

公开(公告)号：US20110309116A1

公开(公告)日：2011-12-22

申请号：US13116240

申请日：2011-05-26

申请人： Takayuki Shindo

发明人： Takayuki Shindo

IPC分类号： A44C5/00

CPC分类号： A44B11/24 ,  A44B11/006 ,  Y10T24/2155 ,  Y10T24/40 ,  Y10T24/4037 ,  Y10T24/4065

摘要： A watch band with a buckle which does not slip off from a band body thereof even when it gets a great shock, for example from collision with an object due to dropping thereof, and a wristwatch with such band. The band body has a pair of spaced attaching parts provided at an end thereof. An engaging member has a connection part connected through a connection pipe to between these attaching parts. A buckle has a pair of arms which hold these attaching parts therebetween. A pair of screws have a thread portion screwed into a screw hole in the end portion of an associated arm of the buckle and a shank part inserted in a nearer end portion of the connection pipe to attach the buckle to the band body so as not to slip off from the connection pipe even when the buckle gets a great shock.

摘要翻译： 具有带扣的表带，即使当它受到很大的冲击时也不会从其带体脱落，例如与物体因其落下的碰撞，以及具有这种带的手表。 带体具有设置在其一端的一对间隔开的附接部分。 接合构件具有通过连接管连接到这些附接部之间的连接部。 带扣具有一对在其间保持这些附接部件的臂。 一对螺钉具有螺纹部分，该螺纹部分拧入带扣的相关臂的端部中的螺纹孔中，以及插入连接管的更靠近端部的柄部，以将带扣附接到带体，从而不会 即使带扣受到很大的冲击，也从连接管上脱落。

公开(公告)号：US20110235475A1

公开(公告)日：2011-09-29

申请号：US13021896

申请日：2011-02-07

申请人： Takayuki Shindo

发明人： Takayuki Shindo

IPC分类号： G04B37/18

CPC分类号： G04B43/002

摘要： A shock absorbing member for a wristwatch including a wristwatch case whose side portions are provided with a pair of bands and an operation member positioned avoiding the pair of bands, and back surface has a case back attached thereto. This shock absorbing member is made of a flexible resin, and includes a peripheral side portion that surrounds the wristwatch case and projects further outward than a top surface of the wristwatch case, and a bottom portion to which the case back is attached. In addition, the peripheral side portion is provided with band holes into which the pair of bands are inserted and an operation hole corresponding to the operation member. Accordingly, even when a strong shock of falling from a high place or the like is received, the shock is unfailingly absorbed.

摘要翻译： 一种手表用的吸震构件，其包括：手表壳体，其侧部设置有一对带;以及操作构件，其设置成避开所述一对带，并且背面安装有壳体。 该冲击吸收构件由柔性树脂制成，并且包括围绕手表壳体并且比手表壳体的顶表面进一步向外突出的周边部分以及安装有背面的底部。 另外，周边部分设置有一对带插入的带孔和对应于操作构件的操作孔。 因此，即使接收到从高处落下等的强烈冲击，也能够充分吸收冲击。

公开(公告)号：US08585282B2

公开(公告)日：2013-11-19

申请号：US13021896

申请日：2011-02-07

申请人： Takayuki Shindo

发明人： Takayuki Shindo

IPC分类号： A44C5/00

CPC分类号： G04B43/002

摘要： A shock absorbing member for a wristwatch including a wristwatch case whose side portions are provided with a pair of bands and an operation member positioned avoiding the pair of bands, and back surface has a case back attached thereto. This shock absorbing member is made of a flexible resin, and includes a peripheral side portion that surrounds the wristwatch case and projects further outward than a top surface of the wristwatch case, and a bottom portion to which the case back is attached. In addition, the peripheral side portion is provided with band holes into which the pair of bands are inserted and an operation hole corresponding to the operation member.

摘要翻译： 一种手表用的吸震构件，其包括：手表壳体，其侧部设置有一对带;以及操作构件，其设置成避开所述一对带，并且背面安装有壳体。 该冲击吸收构件由柔性树脂制成，并且包括围绕手表壳体并且比手表壳体的顶表面进一步向外突出的周边部分以及安装有背面的底部。 另外，周边部分设置有一对带插入的带孔和对应于操作构件的操作孔。

公开(公告)号：US08858915B2

公开(公告)日：2014-10-14

申请号：US12734864

申请日：2008-11-21

申请人： Takayuki Shindo

发明人： Takayuki Shindo

IPC分类号： A61K49/00 ,  C07K14/705 ,  A01K67/027 ,  C12N15/85 ,  G01N33/68 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/68

CPC分类号： G01N33/6872 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0375 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/8509 ,  C12Q1/6883 ,  G01N2500/00 ,  G01N2800/04 ,  Y10T436/143333

摘要： The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.

摘要翻译： 本发明的目的是提供：代谢综合征的治疗或预防剂，其在生物体中具有改善的稳定性; 和别的。 用于代谢综合征的治疗或预防剂包含编码受体活性修饰蛋白（RAMP）2并选自下述（a）至（d）中的DNA或由DNA编码的多肽作为活性成分的DNA： a）具有SEQ ID NO：1所示核苷酸序列的DNA; （b）在严格条件下具有能够与SEQ ID NO：1所示核苷酸序列杂交的核苷酸序列的DNA; （c）具有编码在SEQ ID NO：2所示的氨基酸序列中具有取代，缺失和/或添加一个或多个氨基酸残基的氨基酸序列的核苷酸序列的DNA; 和（d）具有与SEQ ID NO：1所示核苷酸序列具有90％以上同源性的核苷酸序列的DNA。

公开(公告)号：US20120124681A1

公开(公告)日：2012-05-17

申请号：US13383648

申请日：2010-07-16

申请人： Takayuki Shindo ,  Takayuki Sakurai

发明人： Takayuki Shindo ,  Takayuki Sakurai

IPC分类号： A61K49/00 ,  A61K31/711 ,  C12Q1/02 ,  C12N5/10 ,  C12Q1/68 ,  C12N15/11 ,  C12N15/85

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075

摘要： Provided are a DNA fragment, a pharmaceutical composition, and the like, which can simplify the period of creating knockout animals. The DNA fragment includes: a detection sequence that codes for a detection marker other than drug resistance (preferably a visually-detectable marker); a resistance sequence that codes for a resistance marker for a drug that inhibits the proliferation of one or more species of at least prokaryotic organisms; a promoter sequence that is located upstream of the resistance sequence and functions in prokaryotic organisms; and a regulatory sequence that is located upstream of all of the above sequences and, only when inserted into a target region of the genome of at least one species of eukaryotic organism, induces the expression of a sequence located downstream. The detection sequence and the resistance sequence are arranged so as to be capable of action.

摘要翻译： 提供了可以简化产生敲除动物的时间的DNA片段，药物组合物等。 DNA片段包括：编码不同于耐药性的检测标记的检测序列（优选视觉上可检测的标记）; 编码抑制一种或多种至少原核生物的增殖的药物的抗性标记物的抗性序列; 位于抗性序列上游并在原核生物中起作用的启动子序列; 以及位于所有上述序列上游的调节序列，并且仅当插入至少一种真核生物的基因组的靶区域时，诱导位于下游的序列的表达。 检测顺序和电阻序列被配置为能够起作用。

公开(公告)号：US20110027187A1

公开(公告)日：2011-02-03

申请号：US12734864

申请日：2008-11-21

申请人： Takayuki Shindo

发明人： Takayuki Shindo

IPC分类号： A61K49/00 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/53 ,  A61P3/00

CPC分类号： G01N33/6872 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0375 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/8509 ,  C12Q1/6883 ,  G01N2500/00 ,  G01N2800/04 ,  Y10T436/143333

摘要： The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.

摘要翻译： 本发明的目的是提供：代谢综合征的治疗或预防剂，其在生物体中具有改善的稳定性; 和别的。 用于代谢综合征的治疗或预防剂包含编码受体活性修饰蛋白（RAMP）2并选自下述（a）至（d）中的DNA或由DNA编码的多肽作为活性成分的DNA： a）具有SEQ ID NO：1所示核苷酸序列的DNA; （b）在严格条件下具有能够与SEQ ID NO：1所示核苷酸序列杂交的核苷酸序列的DNA; （c）具有编码在SEQ ID NO：2所示的氨基酸序列中具有取代，缺失和/或添加一个或多个氨基酸残基的氨基酸序列的核苷酸序列的DNA; 和（d）具有与SEQ ID NO：1所示核苷酸序列具有90％以上同源性的核苷酸序列的DNA。