公开(公告)号：US07956328B2

公开(公告)日：2011-06-07

申请号：US12511833

申请日：2009-07-29

申请人： S. Kamakshi Sundaram ,  Brian J. Riley ,  Thomas J. Weber ,  Colette A. Sacksteder ,  R. Shane Addleman

发明人： S. Kamakshi Sundaram ,  Brian J. Riley ,  Thomas J. Weber ,  Colette A. Sacksteder ,  R. Shane Addleman

IPC分类号： G01J5/02

CPC分类号： G01N21/552 ,  G01N2021/3595

摘要： An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

摘要翻译： 描述了一种ATR-FTIR设备和系统，其实时地对缺乏对刺激和扰动的活细胞反应。 该系统和装置可以监测实时暴露于各种物理，化学和生物材料以及长时间持续的扰动，包括与具有未知作用模式的刺激相关的扰动（例如， 纳米颗粒）。 该装置和系统也可用于识别特定的化学物质或物质，这些物质或物质描述了对这些扰动的细胞反应。

公开(公告)号：US20110024630A1

公开(公告)日：2011-02-03

申请号：US12511833

申请日：2009-07-29

申请人： S. Kamakshi Sundaram ,  Brian J. Riley ,  Thomas J. Weber ,  Colette A. Sacksteder ,  R. Shane Addleman

发明人： S. Kamakshi Sundaram ,  Brian J. Riley ,  Thomas J. Weber ,  Colette A. Sacksteder ,  R. Shane Addleman

IPC分类号： G01J5/02

CPC分类号： G01N21/552 ,  G01N2021/3595

摘要： An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

摘要翻译： 描述了一种ATR-FTIR设备和系统，其实时地对缺乏对刺激和扰动的活细胞反应。 该系统和装置可以监测实时暴露于各种物理，化学和生物材料以及长时间持续的扰动，包括与具有未知作用模式的刺激相关的扰动（例如， 纳米颗粒）。 该装置和系统也可用于识别特定的化学物质或物质，这些物质或物质描述了对这些扰动的细胞反应。

公开(公告)号：US07553547B2

公开(公告)日：2009-06-30

申请号：US11315646

申请日：2005-12-21

申请人： Glen E. Fryxell ,  Thomas S. Zemanian ,  R. Shane Addleman ,  Christopher L. Aardahl ,  Feng Zheng ,  Brad Busche ,  Oleg B. Egorov

发明人： Glen E. Fryxell ,  Thomas S. Zemanian ,  R. Shane Addleman ,  Christopher L. Aardahl ,  Feng Zheng ,  Brad Busche ,  Oleg B. Egorov

IPC分类号： B32B25/20

CPC分类号： B01J20/3257 ,  B01J20/3225 ,  B82Y30/00 ,  Y10T428/31663

摘要： Backfilled, self-assembled monolayers and methods of making the same are disclosed. The self-assembled monolayer comprises at least one functional organosilane species and a substantially random dispersion of at least one backfilling organosilane species among the functional organosilane species, wherein the functional and backfilling organosilane species have been sequentially deposited on a substrate. The method comprises depositing sequentially a first organosilane species followed by a backfilling organosilane species, and employing a relaxation agent before or during deposition of the backfilling organosilane species, wherein the first and backfilling organosilane species are substantially randomly dispersed on a substrate.

摘要翻译： 公开了回填的自组装单层及其制备方法。 所述自组装单层在所述功能性有机硅烷物质中包含至少一种功能性有机硅烷物质和至少一种回填有机硅烷物质的基本无规分散体，其中所述功能性和回填有机硅烷物质已经顺序地沉积在基材上。 该方法包括依次沉积第一有机硅烷物质，然后沉积有机硅烷物质，并在回填有机硅烷物质沉积之前或期间使用松弛剂，其中第一和回填的有机硅烷物质基本上随机分散在基材上。