公开(公告)号：US20190248831A1

公开(公告)日：2019-08-15

申请号：US16316853

申请日：2017-07-11

申请人： SAGE THERAPEUTICS, INC.

发明人： Albert Jean ROBICHAUD ,  Gabriel MARTINEZ BOTELLA ,  Boyd L. HARRISON ,  Francesco G. SALITURO ,  Andrew GRIFFIN ,  Maria Jesus BLANCO-PILLADO

IPC分类号： C07J41/00 ,  C07J43/00 ,  C07J1/00 ,  A61P25/20 ,  A61P25/08 ,  A61P25/28 ,  A61P5/00 ,  A61P25/18

CPC分类号： C07J41/0005 ,  A61P5/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  C07J1/0029 ,  C07J1/0081 ,  C07J1/0085 ,  C07J7/002 ,  C07J9/00 ,  C07J17/00 ,  C07J41/0011 ,  C07J41/005 ,  C07J41/0066 ,  C07J41/0094 ,  C07J43/003

摘要： Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.