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公开(公告)号：US20180250409A1
公开(公告)日：2018-09-06
申请号：US15759943
申请日：2016-09-12
发明人： Hye Yeong NAM , Bong-Oh KIM , Min-Hyo SEO , Ji-Yeon SON , Ji-Hye CHOI , Sang Hoon KIM
IPC分类号： A61K47/34 , C12N15/113 , A61K9/107 , A61K47/54
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/1075 , A61K31/7088 , A61K47/543 , C12N15/113
摘要： Disclosed are a pharmaceutical composition for anionic drug delivery, and a preparation method therefor, the pharmaceutical composition for anionic drug delivery containing: an anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the anionic drug formed a complex with the cationic lipid, and the complex is encapsulated within a micelle structure formed by the amphiphilic block copolymer and the polylactate.
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公开(公告)号：US20180344638A1
公开(公告)日：2018-12-06
申请号：US15781182
申请日：2016-12-16
发明人： Hye Yeong NAM , Sang-Hee KIM , Min-Hyo SEO , Ji-Yeon SON
CPC分类号： A61K9/00 , A61K9/107 , A61K31/7088 , A61K47/14 , A61K47/30
摘要： Disclosed is a method for preparing a composition for an anionic drug delivery with increased production yield, comprising forming nanoparticles by using electrostatic interaction of an anionic drug and a cationic compound in an aqueous phase; and incorporating the nanoparticles into polymeric micelles comprising an amphiphilic polymer and optionally a polylactic acid salt to increase the electrostatic interaction and hydrophobic binding, thereby increasing the entrapment efficiency of the anionic drug in the formulation.
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公开(公告)号：US20180346410A1
公开(公告)日：2018-12-06
申请号：US15781493
申请日：2016-12-29
发明人： Sungwon CHOI , Hye Yeong NAM , Min-Hyo SEO
IPC分类号： C07C237/10 , C07C231/02 , C07C231/12
摘要： Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.
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4.发明申请公开(公告)号：US20190328903A1
公开(公告)日：2019-10-31
申请号：US16474638
申请日：2017-09-08
发明人： Joung-Woo CHOI , Sang Hoon KIM , Hye Yeong NAM
摘要： Disclosed are a pharmaceutical composition containing plasmid DNA, characterized by that it comprises plasmid DNA as active ingredients; a peptide comprising a nuclear localization signal (NLS) sequence or RGD peptide sequence; a cationic compound; and an amphiphilic copolymer, and the plasmid DNA binds to a peptide to form a complex with the cationic compound and the complex is entrapped in the nanoparticle structure of the amphiphilic block copolymer, and a preparation method thereof.
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5.发明申请公开(公告)号：US20210077406A1
公开(公告)日：2021-03-18
申请号：US16764643
申请日：2018-11-15
发明人： Ji Hye CHOI , Ji Yeon SON , So Jin LEE , Bo Mi KIM , Hye Yeong NAM
IPC分类号： A61K9/19 , A61K9/16 , A61K47/69 , C12N15/113
摘要： Disclosed are a composition and a method for freeze-drying which allow excellent stability, safety, and efficacy to be exhibited at the time of freeze-drying and reconstituting a composition for anionic drug delivery.
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