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公开(公告)号：US10793516B2
公开(公告)日：2020-10-06
申请号：US15781493
申请日：2016-12-29
发明人： Sungwon Choi , Hye Yeong Nam , Min-Hyo Seo
IPC分类号： C07C237/10 , C07C231/02 , C07C237/06 , C07C231/12
摘要： Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.
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公开(公告)号：US10765753B2
公开(公告)日：2020-09-08
申请号：US15540674
申请日：2015-12-28
发明人： Sa Won Lee , Gyeong Hae Kim , Min Hyo Seo
IPC分类号： A61K47/34 , A61K9/19 , C08G63/06 , C08K3/10 , C08K3/16 , A61K9/08 , A61K31/506 , A61K47/26 , A61K31/337 , A61K9/51 , C08K3/22
摘要： The present invention relates to a polymer nanoparticle freeze-dried product, and a preparation method therefor, the polymer nanoparticle freeze-dried product being obtainable by treating, through a freeze-drying process comprising an annealing step, a polymer nanoparticle aqueous solution comprising an amphiphilic block copolymer, a polylactic acid derivative having a carboxyl terminal group, and a freeze-drying adjuvant, wherein the polymer nanoparticle freeze-dried product is reconstituted within five minutes upon reconstitution by means of an aqueous solvent under atmospheric pressure.
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公开(公告)号：US10292932B2
公开(公告)日：2019-05-21
申请号：US15137167
申请日：2016-04-25
发明人： Se-Ho Kim , Ji-Yeon Son , Muhn-Ho La , Sung-Won Choi , Min-Hyo Seo
摘要： Disclosed are an anionic drug-containing polymeric micelle particle comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The particle may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.
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公开(公告)号：US20180250409A1
公开(公告)日：2018-09-06
申请号：US15759943
申请日：2016-09-12
发明人： Hye Yeong NAM , Bong-Oh KIM , Min-Hyo SEO , Ji-Yeon SON , Ji-Hye CHOI , Sang Hoon KIM
IPC分类号： A61K47/34 , C12N15/113 , A61K9/107 , A61K47/54
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/1075 , A61K31/7088 , A61K47/543 , C12N15/113
摘要： Disclosed are a pharmaceutical composition for anionic drug delivery, and a preparation method therefor, the pharmaceutical composition for anionic drug delivery containing: an anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the anionic drug formed a complex with the cationic lipid, and the complex is encapsulated within a micelle structure formed by the amphiphilic block copolymer and the polylactate.
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公开(公告)号：US09795562B2
公开(公告)日：2017-10-24
申请号：US14717641
申请日：2015-05-20
发明人： Sa-Won Lee , Min-Hyo Seo
IPC分类号： A61K9/107 , A61K31/337 , A61K31/436 , A61K9/00 , A61K9/19 , A61K47/34
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/19 , A61K31/337 , A61K31/436 , A61K47/34
摘要： A method for stabilizing a poorly water-soluble drug-containing amphiphilic block copolymer micelle composition via simplified steps in short time is described. Also described is a stabilized poorly water-soluble drug-containing amphiphilic block copolymer micelle composition having improved stability.
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6.发明申请PHARMACEUTICAL COMPOSITION WITH IMPROVED STORAGE STABILITY AND METHOD FOR PREPARING THE SAME 审中-公开具有改进的储存稳定性的药物组合物及其制备方法公开(公告)号：US20170028068A1
公开(公告)日：2017-02-02
申请号：US15222157
申请日：2016-07-28
发明人： Bong Oh KIM , Bum Chan MIN , Ji Yeong KIM , Hye Rim KIM , Min Hyo SEO , Sa Won LEE , Yil Woong YI , Joong Woong CHO , In Ja CHOI
IPC分类号： A61K47/34 , A61K31/337 , A61K47/32 , A61K9/107
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K47/32
摘要： A pharmaceutical composition containing a specific related compound within a specified limit and a method for preparing the same are provided.
摘要翻译： 提供含有特定相关化合物在特定限度内的药物组合物及其制备方法。
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7.发明申请Melt-Extruded Release Controlled Pharmaceutical Composition and Oral Dosage Form Comprising the Same 审中-公开熔融挤出释放控制的药物组合物和包含其的口服剂型公开(公告)号：US20160213621A1
公开(公告)日：2016-07-28
申请号：US14758258
申请日：2013-12-20
发明人： Sang-Yeob Park , Hye-Jung Lim , Kyung-Hee Kim
IPC分类号： A61K9/50 , A61K31/519 , A61K47/32
CPC分类号： A61K9/5026 , A61K9/1635 , A61K31/517 , A61K31/519 , A61K47/32
摘要： Disclosed are a controlled release pharmaceutical composition, comprising a melt-extruded pellet including a water-insoluble ammonium methacrylate copolymer, a polyvinyl acetate, and an active ingredient; and a polymer coating layer including a water-insoluble ammonium methacrylate copolymer formed on the surface of the pellet, and an oral formulation including the pharmaceutical composition.
摘要翻译： 公开了一种控释药物组合物，其包含熔融挤出的丸粒，其包含水不溶性甲基丙烯酸铵共聚物，聚乙酸乙烯酯和活性成分; 以及包含在所述颗粒表面上形成的水不溶性甲基丙烯酸铵共聚物的聚合物涂层和包含所述药物组合物的口服制剂。
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8.发明申请COMPOSITION FOR ANTI-ADHESION, SURGICAL MESH COMPOSITE WITH ANTI-ADHESION PROPERTY COMPRISING THE SAME AND METHOD FOR PRODUCING THEREOF 有权用于抗粘合剂的组合物，具有抗粘连性的外科网络组合物及其生产方法公开(公告)号：US20150045818A1
公开(公告)日：2015-02-12
申请号：US14365924
申请日：2012-12-14
发明人： Sun-Woo Kim , Jun-Bae Kim , Guw-Dong Yeo , Hye-Sung Yoon
CPC分类号： A61L31/041 , A61F2/0063 , A61F2002/009 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61L31/042 , A61L31/06 , A61L31/148 , B32B37/06 , B32B37/12 , B32B37/24 , B32B2305/38 , B32B2307/748 , B32B2309/022 , C08L1/286 , Y10T156/10 , C08L67/04 , C08L1/26
摘要： An anti-adhesion composition with a good anti-adhesion property as well as a good biocompatibility, a surgical mesh composite with anti-adhesion property comprising the same and method for producing the same are provided.
摘要翻译： 提供了具有良好的抗附着性以及良好的生物相容性的抗粘连组合物，具有抗粘连性的外科用网状复合体及其制造方法。
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9.发明申请PERCUTANEOUSLY ABSORBABLE PREPARATION CONTAINING FENTANYL AND HOMOLOGUE THEREOF 审中-公开含有FENTANYL及其同系物的可可吸收制剂公开(公告)号：US20140243765A1
公开(公告)日：2014-08-28
申请号：US14346031
申请日：2012-09-21
发明人： Hyun-Suk Yu , Young-Moo Lee , Hyun-Woo Kim , Hee-Sook Kim
IPC分类号： A61K9/70 , A61K31/4535 , A61K47/16 , A61K47/10 , A61K47/14 , A61K31/4468 , A61K47/22
CPC分类号： A61K9/7038 , A61K9/70 , A61K9/7061 , A61K31/4468 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/16 , A61K47/22
摘要： Disclosed is a transdermal preparation, comprising sequentially-stacked layers of a backing layer, a barrier layer, a drug adhesive layer and a release layer, wherein the drug adhesive layer contains a drug selected from the group consisting of fentanyl, an analogue thereof and a pharmaceutically-acceptable salt thereof, a skin permeation enhancer of the drug, and a polyacrylate adhesive, which shows a high skin permeation with a low drug dosage, equivalent to one with high drug dosage, by increasing the skin permeation rate of drug.
摘要翻译： 公开了一种透皮制剂，其包括背衬层，阻挡层，药物粘合剂层和释放层的顺序层叠的层，其中药物粘合剂层含有选自芬太尼，其类似物和 其药学上可接受的盐，药物的皮肤渗透促进剂和聚丙烯酸酯粘合剂，其通过增加药物的皮肤渗透速率显示出具有相当于药物剂量高的药物用量的低皮肤渗透性。
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公开(公告)号：US20200268776A1
公开(公告)日：2020-08-27
申请号：US16462090
申请日：2017-09-22
发明人： Hye-Jeong YOON , Hye Jin JANG
IPC分类号： A61K31/704 , A61K9/107 , A61K9/16 , A61K31/407 , A61K31/4745 , A61K9/00 , A61K49/04 , A61K47/02 , A61K31/337 , A61P35/00
摘要： The present invention relates to an emulsion composition for chemoembolization comprising a nanoparticle comprising a drug and a biocompatible polymer, a water-soluble contrast agent and a water-insoluble contrast agent, and a water-insoluble drug as well as an aqueous drug can be administered in a form of stable emulsion, and drugs are slowly released, thereby enhancing the effect of chemoembolization.
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