公开(公告)号：US3592816A

公开(公告)日：1971-07-13

申请号：US3592816D

申请日：1967-11-01

申请人： SANDOZ LTD

发明人： TROXLER FRANZ ,  HOFMANN ALBERT

IPC分类号： A61K31/48 ,  C07D457/08 ,  C07D51/70

CPC分类号： A61K31/48 ,  C07D457/08

摘要： THE PRESENT INVENTION RELATES TO COMPOUNDS OF GENERAL FORMULA I,

4-R1,7-CH3,9-((4-R2-PIPERAZIN-1-YL)-CO-)-6A,7,8,9,10,10A-

6H-INDOLO(4,3-FG)QUINOLINE WHERE THE 10,10A POSITION IS

X--Y

IN WHICH R1 IS HYDROGEN OR METHYL, AND R2 IS ARALKYL OF 7 TO 9 CARBON ATOMS, ARYL OR ARYL SUBSTITUTED BY ONE OR MORE OF THE FOLLOWING RADICALS: METHYL, ALKOXY OF 1 TO 4 CARBON ATOMS, CHLORINE OR BROMINE, AND

X--Y IS -CH=C
AND THEIR ACID ADDITION SALTS. THE COMPOUNDS IN WHICH R1 IS HYDROGEN AND

X--Y IS -CH=C
HAVE ANTIDEPRESSIVE PROPERTIES. THE REMAINING COMPOUNDS HAVE SEDATIVE PROPERTIES. THE PREPARATION OF THE COMPOUNDS IS ALSO DESCRIBED.

公开(公告)号：US3586683A

公开(公告)日：1971-06-22

申请号：US3586683D

申请日：1968-04-08

申请人： SANDOZ LTD

发明人： STADLER PAUL ,  HOFMANN ALBERT ,  TROXLER FRANZ

IPC分类号： C07D207/16 ,  C07D487/04 ,  C07D487/10 ,  C07D498/14 ,  C07D519/02 ,  C07D43/20

CPC分类号： C07D487/04 ,  C07D207/16 ,  C07D487/10 ,  C07D519/02

摘要： COMPOUNDS ARE OF THE CLASS OF 2,5(5) - DI(TRI)SUBSTITUTED - 10B - HYDROXY - 3,6 - DIOXO-OCTAHYDRO-OXAZOLO (3,2-A)PYRROLO(2,1-C)PYRAZINE DERIVATIVES OF LYSERGIC ACID AND ARE USEFUL AS VASOTONIC AGENTS. THE COMPOUNLS ARE PREPARED BY REACTING AN APPROPRIATE AMINOCYCLOL WITH LYSERGIC ACID.

公开(公告)号：US3583991A

公开(公告)日：1971-06-08

申请号：US3583991D

申请日：1969-01-13

申请人： SANDOZ LTD

发明人： TROXLER FRANZ ,  HOFMANN ALBERT

IPC分类号： C07D295/04 ,  C07D457/02 ,  C07D51/70

CPC分类号： C07D457/02

摘要： NEW 6-METHYL-8-PIPERAZINYL-METHYLERGOLENE AND -METHYLERGOLINE DERIVATIVES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY.

公开(公告)号：US3652569A

公开(公告)日：1972-03-28

申请号：US3652569D

申请日：1971-01-21

申请人： SANDOZ LTD

发明人： STADLER PAUL ,  HAUTH HARTMUT ,  WERSIN GERNOT ,  GUTTMANN STEPHAN ,  HOFMANN ALBERT ,  STUTZ PETER ,  WILLEMS HANS

IPC分类号： A61K31/48 ,  C07D487/04 ,  C07D498/14 ,  C07D519/02 ,  C07D51/72

CPC分类号： C07D487/04 ,  C07D519/02

摘要： THE INVENTION CONCERNS NEW ERGOT PEPTIDE ALKALOIDS OF THE FORMULA

4-R1,7-(CH3-),9-((2-(H5C2-),3,6-DI(O=),5-R2,10B-(HO-)-

2,3,5,6,9,10,10A,10B-OCTAHYDRO-8H-OXAZOLO(3,2-A)PYRROLO

(2,1-C)PYRAZIN-2-YL)-NH-CO-)-4,6,6A,7,8,9-HEXAHYDRO

INDOLO(4,3-FG)QUINOLINE OR

4,6,6A,7,8,9,10,10A-OCTAHYDRO DERIVATIVE

WHEREIN

10-10A IS -CH2-CH
R1 IS HYDROGEN OR METHYL, AND R2 IS ISOPROPYL OR ISOBUTYL, AND PHARMACEUTICALLY ACCEPTABLE AND ADDITION SALTS THEREOF. THE COMPOUNDS ARE USEFUL IN THE TREATMENT OF MIGRAINE. COMPOUNDS IN WHICH

10-10A IS -CH=C
R1 IS HYDROGEN AND R2 HAS THE ABOVE SIGNIFICANCE ARE ALSO VASOCONSTRICTORS. FURTHERMORE, COMPOUNDS IN WHICH R1 IS HYDROGEN ARE ALSO DIURETICS.

公开(公告)号：US3647801A

公开(公告)日：1972-03-07

申请号：US3647801D

申请日：1963-12-12

申请人： SANDOZ LTD

发明人： PETRZILKA THEODOR ,  HOFMANN ALBERT ,  TROXLER FRANZ ,  FREY ALBERT ,  OTT HANS ,  SCHENK HANSRUEDI

IPC分类号： C07D459/00 ,  C07D57/10

CPC分类号： C07D459/00

摘要： DISCLOSED ARE LEVOROTATORY 10-METHOXY-DESERPIDINE AND RELATED COMPOUNDS USEFULS AS HYPOTENSIVE AGENTS.

公开(公告)号：US3583992A

公开(公告)日：1971-06-08

申请号：US3583992D

申请日：1968-01-30

申请人： SANDOZ LTD

发明人： HOFMANN ALBERT ,  TROXLER FRANZ

IPC分类号： C07D457/06 ,  C07D43/20

CPC分类号： C07D457/06

摘要： THE INVENTION PROVIDES 1-METHYL-D-IYSERGIC ACID OR 1METHYL-9,10-DIHYDRO-D-ISERGIC ACID AMINES OF GENERAL FORMULA I,

4,7-DI(CH3-),9-(R-NH-CO-)ERGOLINE WHERE CARBONS 10 AND 10A

OF THE RING ARE REPLACED WITH X AND Y RESPECTIVELY

IN WHICH R SIGNIFIES AN ALKYL RADICAL OF ROM 3 TO 8 CARBON ATOMS INCLUSIVE SUBSTITUTED BY TWO HYDROXY RADICALS, AND $ SIGNIFIES THE RADICAL

-CH=C
AND THEIR ACID ADDITION SALTS. THE COMPOUNDS ARE INDICATED FOR USE IN THE CHRONIC INTERVAL TREATMENT OF VASCULAR HEADACHES, E.G. MIGRAINE.