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12 条记录 (耗时 0.013 秒)

    4-(2-hydroxy)-3-aminopropoxy)-indole derivatives
    1.
    发明授权
    4-(2-hydroxy)-3-aminopropoxy)-indole derivatives 失效
    4-（2-羟基）-3-氨基丙酸） - 衍生物

    公开(公告)号：US3705907A

    公开(公告)日：1972-12-12

    申请号：US3705907D

    申请日：1970-06-15

    申请人： SANDOZ LTD

    发明人： TROXLER FRANZ

    IPC分类号： C07D209/12 ,  C07D209/42 ,  C07D27/56

    CPC分类号： C07D209/12 ,  C07D209/42

    摘要： THE INVENTION CONCERNS NOVEL COMPOUNDS OF FORMULA:

    2-R2,4-(R1-NH-CH2-CH(-OH)-CH2-O-)INDOLE

    IN WHICH R1 IS LOWER ALKYL, CYCLOALKYL HAVING 3 TO 4 CARBON ATOMS, PHENYLALKYL OF 8 TO 10 CARBON ATOMS OR 1-ADAMANTYL, AND R2 IS HYDROXYMETHYL OR COOR5, WHERE R5 IS A HYDROGEN ATOM OR LOWER ALKYL RADICAL, WHICH ARE USEFUL AS B-ADRENERGIC BLOCKING AGENTS. PROCESSES FOR THE PRODUCTION OF THE COMPOUNDS OF THE INVENTION AND INTERMEDIATES FOR THE USE THEREIN ARE DESCRIBED.

    4-(2-hydroxy-3-aminopropoxy)-9-fluorenones and the salts thereof
    4.
    发明授权
    4-(2-hydroxy-3-aminopropoxy)-9-fluorenones and the salts thereof 失效
    4-（2-羟基-3-氨基丙酸）-9-氟代芬兰及其盐

    公开(公告)号：US3671587A

    公开(公告)日：1972-06-20

    申请号：US3671587D

    申请日：1970-05-26

    申请人： SANDOZ LTD

    发明人： TROXLER FRANZ ,  SEEMANN FRITZ

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A61P9/02 ,  A61P9/06 ,  A61P25/02 ,  C07C67/00 ,  C07C213/00 ,  C07C217/38 ,  C07C93/06

    CPC分类号： A61K31/135 ,  C07C2603/18

    摘要： The present invention provides fluorene derivatives of formula,

    IN WHICH R is isopropyl, secondary butyl, tertiary butyl, 3phenylpropyl, 1-cyano-2-propyl,tert. pentyl or 3-pentyl, and either X is hydrogen and Y is hydroxy, or X and Y together are oxo, and pharmaceutically acceptable acid addition salts thereof. The compounds of the invention exhibit Beta -blocking activity.

    摘要翻译： 本发明提供式Ⅳ的芴衍生物，其中R是异丙基，仲丁基，叔丁基，3-苯基丙基，1-氰基-2-丙基，叔丁基， 戊基或3-戊基，并且X为氢，Y为羟基，或X和Y一起为氧代，及其药学上可接受的酸加成盐。

    Certain 5h 8h-thiazolo(3 2-a)pyrrolo(2 3-d)pyrimidin-5-ones
    5.
    发明授权
    Certain 5h 8h-thiazolo(3 2-a)pyrrolo(2 3-d)pyrimidin-5-ones 失效
    某些5H 8H-THIAZOLO（3 2-A）吡咯烷（2 3-D）吡咯烷-5-酮

    公开(公告)号：US3657245A

    公开(公告)日：1972-04-18

    申请号：US3657245D

    申请日：1970-08-20

    申请人： SANDOZ LTD

    发明人： BORMANN GERHARD ,  TROXLER FRANZ

    IPC分类号： C07D513/14 ,  C07D99/06

    CPC分类号： C07D513/14

    摘要： THE PRESENT INVENTION CONCERNS NEW COMPOUNDS OF THE FORMULA:

    2-B,3-A,6-((4-R4-PHENYL)-CH(-R1)-CH(-R2)-N(-R3)-CH2-),

    7-CH3-2,3-DIHYDRO-5H,8H-TRIAZOLO(3,2-A)PYRROLO(2,3-D)-

    PYRIMIDIN-5-ONE

    WHEREIN A AND B TOGETHER FORM A SINGLE BOND, OR A IS ETHOXY OR HYDROXYMETHYL AND B IS HYDROGEN, R1 IS HYDROGEN OR HYDROXY, R2 IS HYDROGEN OR METHYL, R3 IS METHYL, OR R3 IS HYDROGEN WHEN R2 IS METHYL, AND R4 IS HYDROGEN, METHOXY OR CHLORINE. THE COMPOUNDS ARE USEFUL IN THE PROPHYLAXIS OF THROMBOSIS AND EMBOLISM AND FOR IMPROVING MICROCIRCULATION.

    N-substituted piperazides of lysergic acid
    6.
    发明授权
    N-substituted piperazides of lysergic acid 失效
    N取代的柠檬酸管

    公开(公告)号：US3592816A

    公开(公告)日：1971-07-13

    申请号：US3592816D

    申请日：1967-11-01

    申请人： SANDOZ LTD

    发明人： TROXLER FRANZ ,  HOFMANN ALBERT

    IPC分类号： A61K31/48 ,  C07D457/08 ,  C07D51/70

    CPC分类号： A61K31/48 ,  C07D457/08

    摘要： THE PRESENT INVENTION RELATES TO COMPOUNDS OF GENERAL FORMULA I,

    4-R1,7-CH3,9-((4-R2-PIPERAZIN-1-YL)-CO-)-6A,7,8,9,10,10A-

    6H-INDOLO(4,3-FG)QUINOLINE WHERE THE 10,10A POSITION IS

    X--Y

    IN WHICH R1 IS HYDROGEN OR METHYL, AND R2 IS ARALKYL OF 7 TO 9 CARBON ATOMS, ARYL OR ARYL SUBSTITUTED BY ONE OR MORE OF THE FOLLOWING RADICALS: METHYL, ALKOXY OF 1 TO 4 CARBON ATOMS, CHLORINE OR BROMINE, AND

    X--Y IS -CH=C
    AND THEIR ACID ADDITION SALTS. THE COMPOUNDS IN WHICH R1 IS HYDROGEN AND

    X--Y IS -CH=C
    HAVE ANTIDEPRESSIVE PROPERTIES. THE REMAINING COMPOUNDS HAVE SEDATIVE PROPERTIES. THE PREPARATION OF THE COMPOUNDS IS ALSO DESCRIBED.

    4-(3-amino-2-hydroxy-propoxy) indole derivatives
    9.
    发明授权
    4-(3-amino-2-hydroxy-propoxy) indole derivatives 失效
    4-（3-氨基-2-羟基 - 丙氧基）吲哚衍生物

    公开(公告)号：US3699123A

    公开(公告)日：1972-10-17

    申请号：US3699123D

    申请日：1971-03-16

    申请人： SANDOZ LTD

    发明人： SEEMANN FRITZ ,  TROXLER FRANZ

    IPC分类号： C07D209/42 ,  C07D27/56

    CPC分类号： C07D209/42

    摘要： THE PRESENT INVENTION CONCERNS NOVEL COMPOUNDS OF THE FORMULA:

    2-(R3-N(-R4)-CO-),3-R2,4-(R1-NH-CH2-CH(-OH)-CH2-O-)INDOLE

    WHEREIN R1 IS LOWER ALKYL, CYCLOALKYL OF 3 OR 4 CARBON ATOMS OR PHENYALKYL OF AT LEAST 8 CARBON ATOMS, THE PHENYL NUCLEUS THEREOF BEING SEPARATED FROM THE NITROGEN ATOM BY AT LEAST TWO ALKYL CARBON ATOMS, R2 IS HYDROGEN OR METHYL, AND EACH OF R3 AND R4 IS HYDROGEN OR LOWER ALKYL, OR R3 IS AMINO, LOWER ALKYLAMINO, CYCLOALKYL OF 3 OR 4 CARBON ATOMS OR PHENYL, AND R4 IS HYDROGEN, OR R3 AND R4 TOGETHER WITH THE NITROGEN ATOMS TO WHICH THEY ARE BOUND, ARE 1-PYRROLIDINYL, 1-PIPERIDINYL OR 1-MORPHOLINYL, AND ACID ADDITION SALTS THEREOF. THE COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS HAVING A BLOCKING EFFECT ON THE ADRENEGIC B-RECEPTORS.

    4-(2-hydroxy-3-amino propoxy)-indole derivatives
    10.
    发明授权
    4-(2-hydroxy-3-amino propoxy)-indole derivatives 失效
    4-（2-羟基-3-氨基丙氧基） - 衍生物

    公开(公告)号：US3696121A

    公开(公告)日：1972-10-03

    申请号：US3696121D

    申请日：1970-07-17

    申请人： SANDOZ LTD

    发明人： TROXLER FRANZ

    IPC分类号： C07D209/43 ,  C07D209/12 ,  C07D27/56

    CPC分类号： C07D209/12 ,  Y10S514/821

    摘要： The invention concerns new indol derivatives of the formula:

    WHEREIN R1 is lower alkyl, cycloalkyl of three or four carbon atoms, or 3-phenylpropyl, as well as processes for the production thereof. The compounds have a blcoking effect on the vascular adrenergic Beta -receptors.

    摘要翻译： 本发明涉及下式的新的吲哚衍生物：