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28 条记录 (耗时 0.055 秒)

    Isomannide derivatives as inhibitors of soluble epoxide hydrolase
    9.
    发明授权
    Isomannide derivatives as inhibitors of soluble epoxide hydrolase 有权
    异烟肼衍生物作为可溶性环氧化物水解酶的抑制剂

    公开(公告)号：US09540391B2

    公开(公告)日：2017-01-10

    申请号：US14761270

    申请日：2014-01-16

    申请人： SANOFI

    发明人： Katrin Lorenz ,  Kristin Breitschopf ,  Hartmut Strobel ,  Maria Mendez-Perez ,  Li-hsing Wang ,  Alexander Schiffer ,  Joseph T. Kim ,  Hans-Peter Nestler ,  Mark Drew

    IPC分类号： C07D493/04 ,  C07D519/00

    CPC分类号： C07D493/04 ,  C07D519/00

    摘要： The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明涉及式（I）化合物，其中R1，R11，R12和X具有权利要求中所示的含义。 式I的化合物是有价值的药理活性化合物。 它们是高效和选择性可溶性环氧化物水解酶抑制剂，并且适用于例如治疗和预防肾衰竭，糖尿病肾病，2型糖尿病，炎症或可能在疼痛，血脂异常和动脉粥样硬化中显示有益效果。 本发明还涉及式（I）化合物的制备方法，其用途，特别是药物中的活性成分，以及包含它们的药物制剂。

    Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals
    10.
    发明申请
    Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals 有权
    熔融吡咯二甲酰胺及其作为药物的用途

    公开(公告)号：US20150018342A1

    公开(公告)日：2015-01-15

    申请号：US14375273

    申请日：2013-02-01

    申请人： SANOFI

    发明人： Laurent Bialy ,  Katrin Lorenz ,  Klaus Wirth ,  Klaus Steinmeyer ,  Gerhard Hessler

    IPC分类号： C07D513/04 ,  C07D498/04 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D498/04 ,  C07D513/04

    摘要： The present invention relates to fused pyrroledicarboxamides of the formula (I), in which R1 to R9, X, m and n are as defined in the claims. The compounds of the formula (I) are inhibitors of the acid-sensitive potassium channel TASK-1 and suitable for the treatment of TASK-1 channel-mediated diseases such as arrhythmias, in particular atrial arrhythmias like atrial fibrillation or atrial flutter, and respiratory disorders, in particular sleep-related respiratory disorders like sleep apnea, for example.

    摘要翻译： 本发明涉及式（I）的稠合吡咯烷二酰胺，其中R 1至R 9，X，m和n如权利要求中所定义。 式（I）化合物是酸敏感性钾通道TASK-1的抑制剂，适用于治疗TASK-1通道介导的疾病如心律不齐，特别是心房颤动或心房扑动等房性心律失常，呼吸 障碍，特别是睡眠呼吸障碍，例如睡眠呼吸暂停。