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公开(公告)号：US20200231573A1
公开(公告)日：2020-07-23
申请号：US16633382
申请日：2018-09-20
发明人： Byeong Moon Kim , Sung Key Jang , Su Young You , Il Hak Bae , Heejo Moon , Byeong Wook Kim , Hee Sun Kim , Jaegon Mun
IPC分类号： C07D403/12 , C07D403/14 , C07D491/113 , C07D519/00 , C07D413/14 , A23L33/10 , A61P31/14
摘要： The present invention relates to a fluorene derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the same as an effective ingredient for preventing or treating HCV-related disease. A fluorene derivative according to the present invention is identified to exhibit an antiviral performance against not only HCV, but also highly against HCV mutants, particularly double mutants and thus can be used in a pharmaceutical composition for prevention or treatment of HCV-caused liver disease, such as acute hepatitis C, chronic hepatitis C, liver cirrhosis, hepatocellular cancer, etc., particularly, liver disease caused by mutants of HCV. The derivative can be useful in a pharmaceutical composition for prevention or treatment of HCV-related liver disease by which the problem of resistant mutation against conventional therapeutic agents is solved.
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公开(公告)号：US11021455B2
公开(公告)日：2021-06-01
申请号：US16309710
申请日：2017-06-13
发明人： Byeong Moon Kim , Bong Kyu Choi , Jae Hyun Sim , Eun Ju Ryu , Ji Su Park , Il Hak Bae
IPC分类号： C07D307/88 , A61P31/04 , C07D209/46 , C07D307/93
摘要： The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.
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公开(公告)号：US11261175B2
公开(公告)日：2022-03-01
申请号：US16633382
申请日：2018-09-20
发明人： Byeong Moon Kim , Sung Key Jang , Young Su You , Il Hak Bae , Heejo Moon , Byeong Wook Kim , Hee Sun Kim , Jaegon Mun
IPC分类号： C07D403/12 , A23L33/10 , A61P31/14 , C07D403/14 , C07D413/14 , C07D491/113 , C07D519/00
摘要： The present invention relates to a fluorene derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the same as an effective ingredient for preventing or treating HCV-related disease. A fluorene derivative according to the present invention is identified to exhibit an antiviral performance against not only HCV, but also highly against HCV mutants, particularly double mutants and thus can be used in a pharmaceutical composition for prevention or treatment of HCV-caused liver disease, such as acute hepatitis C, chronic hepatitis C, liver cirrhosis, hepatocellular cancer, etc., particularly, liver disease caused by mutants of HCV. The derivative can be useful in a pharmaceutical composition for prevention or treatment of HCV-related liver disease by which the problem of resistant mutation against conventional therapeutic agents is solved.
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公开(公告)号：US09598362B2
公开(公告)日：2017-03-21
申请号：US14884356
申请日：2015-10-15
发明人： Sung Key Jang , Byeong Moon Kim , Il Hak Bae , Jin Kyu Choi , Sun Ju Keum , Seung Gi Lee , Hee Sun Kim
IPC分类号： C07D207/16 , C07D207/24 , C07D277/06 , C07D211/60 , C07K5/062 , C07K5/065 , C07D405/14
CPC分类号： C07D207/16 , A23L33/10 , A23V2002/00 , C07D207/24 , C07D211/60 , C07D277/06 , C07D405/14 , C07K5/06026 , C07K5/06034 , C07K5/06078
摘要： The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.
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