专利检索 ap:("SERUM INSTITUTE OF INDIA PRIVATE LIMITED") AND inv:"Peddi Reddy Srinivas Reddy" 第 1 页

1.

发明授权
Feeding strategies and purification processes for monoclonal antibody production 有权

公开(公告)号：US10233231B2

公开(公告)日：2019-03-19

申请号：US15203035

申请日：2016-07-06

申请人： SERUM INSTITUTE OF INDIA PRIVATE LIMITED

发明人： Dhere Rajeev Mhalasakant , Pisal Sambhaji Shankar , Peddi Reddy Srinivas Reddy , Singh Digamber Chahar , Pardeep Gupta

IPC分类号： C07K16/00 , C07K16/10 , A61K39/395 , C07K1/22

摘要： This invention provides an improved process for manufacturing a Rabies monoclonal antibody (HuMab 17C7) that results in low osmolality, minimum secondary metabolites like ammonia and lactate, enhanced cell growth and productivity, minimum aggregation or degradation of monoclonal antibody during purification, thereby improving potency of monoclonal antibody (HuMab 17C7) as compared to human rabies immunoglobulin (hRIG).