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公开(公告)号：US10898509B2
公开(公告)日：2021-01-26
申请号：US15576477
申请日：2016-05-20
发明人： Zhenqing Zhang , Jie Hao , Shichang Sun , Huiling Zhang
IPC分类号： A61K31/715 , A61P25/00 , A61P9/10 , C07H7/033 , C08B31/18 , C07H1/00 , C07H15/04 , C08L3/10 , C07C31/08 , C07C31/04
摘要： An oxidized α-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant starch, especially soluble starch, in the natural world as the raw material, all 6-site hydroxyl groups of the starch α-1,4-polyglucose are oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
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公开(公告)号：US10898508B2
公开(公告)日：2021-01-26
申请号：US15576454
申请日：2016-05-20
发明人： Zhenqing Zhang , Jie Hao , Shichang Sun , Huiling Zhang
摘要： An oxidized β-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose β-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
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